C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Wolfram syndrome 1 homolog (human)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000039474 Wfs1 10090 - 5:36966104-36988982 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000043964 Wfs1-001 36966104-36988982 protein_coding
  ENSMUST00000166339 Wfs1-002 36966107-36988933 protein_coding
  ENSMUST00000167937 Wfs1-003 36968501-36976956 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000043964ENSMUST00000166339ENSMUST00000167937
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000043964 5.258±2.05 10.269±4.02 7.453±3.45 6.380±7.28 4.257±1.52 4.132±0.49 25.481±3.37 5.917±1.92 1.182±0.43 7.064±1.35 21.187±2.22 8.110±2.77 12.842±9.57 0.450±0.36
ENSMUST00000166339 N/A 5.622±2.84 N/A 7.811±7.61 N/A N/A N/A 0.915±0.00 0.158±0.00 N/A N/A 3.240±1.07 6.783±4.42 N/A
ENSMUST00000167937 N/A N/A N/A 126.447±0.00 N/A N/A N/A N/A N/A N/A N/A 25.244±0.00 36.792±2.78 0.992±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00032H CIL_00032H_0002 CGP 5:36868513-36988982

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001822 ISS kidney development
GO:0003091 ISS renal water homeostasis
GO:0005215 IDA transporter activity
GO:0005516 IEA calmodulin binding
GO:0005783 IDA endoplasmic reticulum
GO:0007601 ISS visual perception
GO:0007605 ISS sensory perception of sound
GO:0030176 ISS integral component of endoplasmic reticulum membrane
GO:0030425 ISS dendrite
GO:0030433 IDA ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 IMP endoplasmic reticulum unfolded protein response
GO:0031398 IDA positive regulation of protein ubiquitination
GO:0031625 IDA ubiquitin protein ligase binding
GO:0032469 ISS endoplasmic reticulum calcium ion homeostasis
GO:0033613 IDA activating transcription factor binding
GO:0034976 IDA response to endoplasmic reticulum stress
GO:0042048 IEA olfactory behavior
GO:0042593 ISS glucose homeostasis
GO:0043069 ISS negative regulation of programmed cell death
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0045862 IDA positive regulation of proteolysis
GO:0045927 IMP positive regulation of growth
GO:0048306 IEA calcium-dependent protein binding
GO:0050821 IMP protein stabilization
GO:0050877 ISS neurological system process
GO:0051117 IDA ATPase binding
GO:0051247 ISS positive regulation of protein metabolic process
GO:0051726 NAS regulation of cell cycle
GO:0051928 ISS positive regulation of calcium ion transport
GO:0055074 ISS calcium ion homeostasis
GO:0070845 IDA polyubiquitinated misfolded protein transport
GO:1902236 IMP negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:2000675 IMP negative regulation of type B pancreatic cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062341 wfs1a Wolfram syndrome 1a (wolframin) protein_coding Danio_rerio
ENSDARG00000074617 wfs1b Wolfram syndrome 1b (wolframin) protein_coding Danio_rerio
ENSG00000109501 WFS1 Wolfram syndrome 1 (wolframin) protein_coding Homo_sapiens

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