C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: 5-hydroxytryptamine (serotonin) receptor 2C
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000041380 Htr2c 10090 + X:146962513-147197277 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000036303 Htr2c-002 146962513-147197274 protein_coding
  ENSMUST00000096299 Htr2c-001 146962514-147197277 protein_coding
  ENSMUST00000112831 Htr2c-006 146963023-147183152 protein_coding
  ENSMUST00000131999 Htr2c-004 146962513-147078064 retained_intron
  ENSMUST00000134368 Htr2c-007 146962630-147072529 processed_transcript
  ENSMUST00000149260 Htr2c-005 146962513-146989328 retained_intron
  ENSMUST00000156697 Htr2c-003 146962514-147197277 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainLiverLungMuscleTestisENSMUST00000036303ENSMUST00000096299ENSMUST00000112831ENSMUST00000134368ENSMUST00000149260ENSMUST00000156697
Transcript ID Bladder Brain Liver Lung Muscle Testis
ENSMUST00000036303 N/A 2.095±1.01 0.003±0.00 0.147±0.04 N/A N/A
ENSMUST00000096299 N/A 0.272±0.00 N/A N/A N/A N/A
ENSMUST00000112831 N/A N/A 0.021±0.00 N/A N/A N/A
ENSMUST00000134368 N/A N/A 0.014±0.00 0.170±0.00 N/A N/A
ENSMUST00000149260 N/A N/A N/A 0.061±0.00 N/A N/A
ENSMUST00000156697 0.004±0.00 1.186±0.72 0.002±0.00 0.182±0.04 0.009±0.00 0.027±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000718 CIL_000718_0002 CGP X:145446425-147197277
CIL_000719 CIL_000719_0002 CGP X:146962513-147429192

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001587 ISS Gq/11-coupled serotonin receptor activity
GO:0001662 IMP behavioral fear response
GO:0004993 IMP serotonin receptor activity
GO:0005886 IEA plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0006182 IEA cGMP biosynthetic process
GO:0006874 IEA cellular calcium ion homeostasis
GO:0007200 IEA phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007208 IMP phospholipase C-activating serotonin receptor signaling pathway
GO:0007210 IEA serotonin receptor signaling pathway
GO:0007626 IEA locomotory behavior
GO:0007631 IMP feeding behavior
GO:0008144 IEA drug binding
GO:0010513 IEA positive regulation of phosphatidylinositol biosynthetic process
GO:0031644 IMP regulation of neurological system process
GO:0032098 IMP regulation of appetite
GO:0042493 IEA response to drug
GO:0043397 IMP regulation of corticotropin-releasing hormone secretion
GO:0045600 IMP positive regulation of fat cell differentiation
GO:0051209 IEA release of sequestered calcium ion into cytosol
GO:0051378 ISO serotonin binding
GO:0051482 IMP positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0071886 IEA 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013210 htr2cl2 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 2 protein_coding Danio_rerio
ENSDARG00000018228 htr2cl1 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 protein_coding Danio_rerio
ENSG00000147246 HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled protein_coding Homo_sapiens

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