C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: adrenergic receptor, alpha 1a
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000045875 Adra1a 10090 + 14:66635251-66733462 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000054661 Adra1a-002 66635258-66733329 protein_coding
  ENSMUST00000159068 Adra1a-004 66635341-66729984 protein_coding
  ENSMUST00000159365 Adra1a-001 66635251-66733462 protein_coding
  ENSMUST00000160647 Adra1a-005 66635309-66640333 retained_intron
  ENSMUST00000161339 Adra1a-003 66635556-66732741 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000054661ENSMUST00000159068ENSMUST00000159365ENSMUST00000160647ENSMUST00000161339
Transcript ID Adipose Adrenal Bladder Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000054661 0.490±0.00 N/A N/A N/A N/A N/A N/A 0.012±0.00 N/A 0.389±0.00 0.022±0.00 0.008±0.00 0.007±0.00
ENSMUST00000159068 N/A 0.559±0.11 0.005±0.00 N/A N/A N/A N/A 0.040±0.07 N/A 0.105±0.00 0.018±0.00 0.011±0.00 0.049±0.03
ENSMUST00000159365 N/A 1.049±0.30 0.014±0.00 1.728±0.59 0.085±0.04 N/A 2.235±0.70 0.427±0.23 2.074±0.00 0.178±0.11 0.287±0.24 0.009±0.00 0.004±0.00
ENSMUST00000160647 N/A 0.580±0.00 0.008±0.00 0.899±0.00 N/A N/A N/A 0.008±0.00 N/A N/A 0.129±0.04 0.003±0.00 0.025±0.00
ENSMUST00000161339 1.358±0.16 1.053±0.27 0.045±0.00 1.047±0.26 0.221±0.06 0.902±0.00 1.894±0.50 0.331±0.25 3.062±1.63 0.257±0.00 0.399±0.12 0.022±0.01 0.023±0.02

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001985 IMP negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001994 IMP norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001996 IGI positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997 IGI positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0003084 IEA positive regulation of systemic arterial blood pressure
GO:0004937 ISO alpha1-adrenergic receptor activity
GO:0005634 ISS nucleus
GO:0005886 IEA plasma membrane
GO:0007200 IDA phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007202 IEA activation of phospholipase C activity
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007512 IGI adult heart development
GO:0007568 IEA aging
GO:0009725 IEA response to hormone
GO:0010460 IEA positive regulation of heart rate
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016049 IGI cell growth
GO:0019229 IEA regulation of vasoconstriction
GO:0030018 IEA Z disc
GO:0030315 IEA T-tubule
GO:0031965 ISS nuclear membrane
GO:0032230 IEA positive regulation of synaptic transmission, GABAergic
GO:0035024 ISO negative regulation of Rho protein signal transduction
GO:0035265 IGI organ growth
GO:0042493 IEA response to drug
GO:0043410 IGI positive regulation of MAPK cascade
GO:0045760 IEA positive regulation of action potential
GO:0045907 IEA positive regulation of vasoconstriction
GO:0045987 IDA positive regulation of smooth muscle contraction
GO:0046982 ISS protein heterodimerization activity
GO:0055117 IEA regulation of cardiac muscle contraction
GO:0060073 IEA micturition
GO:0060402 IEA calcium ion transport into cytosol
GO:0060452 IEA positive regulation of cardiac muscle contraction
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0071875 IEA adrenergic receptor signaling pathway
GO:0090037 IEA positive regulation of protein kinase C signaling
GO:0097195 IDA pilomotor reflex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000027638 adra1ab adrenergic, alpha-1Ab, receptor protein_coding Danio_rerio
ENSDARG00000028725 ADRA1A (2 of 2) adrenoceptor alpha 1A protein_coding Danio_rerio
ENSG00000120907 ADRA1A adrenoceptor alpha 1A protein_coding Homo_sapiens

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