C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hairy and enhancer of split 5 (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000048001 Hes5 10090 + 4:154960923-154962371 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000049621 Hes5-001 154960923-154962371 protein_coding
  ENSMUST00000151480 Hes5-003 154960971-154961406 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000049621ENSMUST00000151480
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000049621 0.110±0.02 0.083±0.04 0.057±0.04 23.917±15.38 0.462±0.16 0.146±0.07 0.038±0.01 0.024±0.00 0.094±0.09 0.054±0.05 0.127±0.00 0.115±0.04 0.020±0.01 0.386±0.15
ENSMUST00000151480 0.322±0.00 0.477±0.18 N/A N/A N/A N/A 0.210±0.00 0.141±0.00 N/A N/A N/A 0.411±0.14 0.025±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007XZ CIL_0007XZ_0002 VISTA 4:154471105-155072345
CIL_0007QV CIL_0007QV_0002 VISTA 4:154934679-155536167

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003682 IEA chromatin binding
GO:0003690 IEA double-stranded DNA binding
GO:0005515 IPI protein binding
GO:0005654 TAS nucleoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006461 IDA protein complex assembly
GO:0007155 IGI cell adhesion
GO:0007219 NAS Notch signaling pathway
GO:0007224 IDA smoothened signaling pathway
GO:0007420 IMP brain development
GO:0008134 NAS transcription factor binding
GO:0008284 ISS positive regulation of cell proliferation
GO:0014003 IMP oligodendrocyte development
GO:0021537 IGI telencephalon development
GO:0021781 IMP glial cell fate commitment
GO:0021861 IEA forebrain radial glial cell differentiation
GO:0021915 IGI neural tube development
GO:0022010 IMP central nervous system myelination
GO:0030182 IEA neuron differentiation
GO:0030513 IGI positive regulation of BMP signaling pathway
GO:0031641 IMP regulation of myelination
GO:0042491 IMP auditory receptor cell differentiation
GO:0042517 IDA positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042668 IMP auditory receptor cell fate determination
GO:0043010 IMP camera-type eye development
GO:0045595 IMP regulation of cell differentiation
GO:0045665 IGI negative regulation of neuron differentiation
GO:0045747 IMP positive regulation of Notch signaling pathway
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0046427 IDA positive regulation of JAK-STAT cascade
GO:0046983 IEA protein dimerization activity
GO:0048469 IGI cell maturation
GO:0048661 ISS positive regulation of smooth muscle cell proliferation
GO:0048708 IDA astrocyte differentiation
GO:0048712 IDA negative regulation of astrocyte differentiation
GO:0048715 IDA negative regulation of oligodendrocyte differentiation
GO:0050767 IGI regulation of neurogenesis
GO:0051216 IMP cartilage development
GO:0072049 IEP comma-shaped body morphogenesis
GO:0072050 IEP S-shaped body morphogenesis
GO:0072086 IEP specification of loop of Henle identity
GO:0072282 IEP metanephric nephron tubule morphogenesis
GO:0097150 IMP neuronal stem cell maintenance
GO:2000737 ISS negative regulation of stem cell differentiation
GO:2000974 ISS negative regulation of pro-B cell differentiation
GO:2000978 IEA negative regulation of forebrain neuron differentiation
GO:2000981 IMP negative regulation of inner ear receptor cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000032963 her12 hairy-related 12 protein_coding Danio_rerio
ENSDARG00000054560 ZGC:136520 hairy and enhancer of split-related 15.2 (her15.2), mRNA protein_coding Danio_rerio
ENSDARG00000054562 her15.1 hairy and enhancer of split-related 15, tandem duplicate 1 protein_coding Danio_rerio
ENSG00000197921 HES5 hes family bHLH transcription factor 5 protein_coding Homo_sapiens

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