C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein kinase, AMP-activated, alpha 1 catalytic subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000050697 Prkaa1 10090 + 15:5143861-5181899 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000051186 Prkaa1-201 5143861-5181899 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000051186
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000051186 8.345±1.25 3.923±1.62 9.078±1.86 4.207±0.93 6.019±0.72 4.990±0.37 2.787±0.30 4.489±0.56 4.241±2.90 6.420±0.67 1.765±0.43 5.293±2.69 6.017±2.11 4.082±1.14

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IEA activation of MAPK activity
GO:0003682 IDA chromatin binding
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004679 IDA AMP-activated protein kinase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0006006 IMP glucose metabolic process
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006633 IEA fatty acid biosynthetic process
GO:0006695 IEA cholesterol biosynthetic process
GO:0006914 IEA autophagy
GO:0008022 IEA protein C-terminus binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0008610 IDA lipid biosynthetic process
GO:0009411 IMP response to UV
GO:0009631 IEA cold acclimation
GO:0010332 IMP response to gamma radiation
GO:0010508 IMP positive regulation of autophagy
GO:0010628 IEA positive regulation of gene expression
GO:0014823 IEA response to activity
GO:0016055 IEA Wnt signaling pathway
GO:0016324 IEA apical plasma membrane
GO:0019395 IMP fatty acid oxidation
GO:0019900 IEA kinase binding
GO:0031000 IEA response to caffeine
GO:0031588 ISS AMP-activated protein kinase complex
GO:0031669 IDA cellular response to nutrient levels
GO:0032007 IMP negative regulation of TOR signaling
GO:0035174 IDA histone serine kinase activity
GO:0035404 IDA histone-serine phosphorylation
GO:0042149 IDA cellular response to glucose starvation
GO:0042542 IMP response to hydrogen peroxide
GO:0042593 IMP glucose homeostasis
GO:0042752 IMP regulation of circadian rhythm
GO:0043066 IMP negative regulation of apoptotic process
GO:0043234 IEA protein complex
GO:0045821 ISS positive regulation of glycolytic process
GO:0046872 IEA metal ion binding
GO:0047322 IEA [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO:0048511 IEA rhythmic process
GO:0050321 IEA tau-protein kinase activity
GO:0050405 IEA [acetyl-CoA carboxylase] kinase activity
GO:0050995 IDA negative regulation of lipid catabolic process
GO:0051291 IEA protein heterooligomerization
GO:0055089 ISS fatty acid homeostasis
GO:0060627 IEA regulation of vesicle-mediated transport
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0071361 IEA cellular response to ethanol
GO:0071417 IEA cellular response to organonitrogen compound
GO:0071456 IEA cellular response to hypoxia
GO:1901563 IMP response to camptothecin
GO:2000505 ISS regulation of energy homeostasis
GO:2001274 IEA negative regulation of glucose import in response to insulin stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060596 prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit protein_coding Danio_rerio
ENSG00000132356 PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit protein_coding Homo_sapiens

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