C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: activin receptor IIA
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000052155 Acvr2a 10090 + 2:48814109-48903269 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000063886 Acvr2a-001 48814109-48903269 protein_coding
  ENSMUST00000156681 Acvr2a-002 48890389-48900248 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000063886ENSMUST00000156681
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000063886 4.305±0.94 8.180±2.69 5.497±0.07 17.193±10.16 4.539±1.42 5.597±2.36 3.113±0.25 3.341±0.45 3.203±0.64 8.385±1.14 2.468±0.60 5.910±2.08 4.162±1.68 3.227±1.23
ENSMUST00000156681 N/A N/A N/A 22.416±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 12.224±0.31 11.881±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007GY CIL_0007GY_0002 CGP 2:44983634-48903269
CIL_0006MB CIL_0006MB_0002 CGP 2:48814109-48950277

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001702 IGI gastrulation with mouth forming second
GO:0001934 ISO positive regulation of protein phosphorylation
GO:0004674 TAS protein serine/threonine kinase activity
GO:0004702 IEA receptor signaling protein serine/threonine kinase activity
GO:0005024 IEA transforming growth factor beta-activated receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005886 TAS plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007283 IGI spermatogenesis
GO:0007368 IGI determination of left/right symmetry
GO:0007498 IMP mesoderm development
GO:0008584 IMP male gonad development
GO:0009952 IGI anterior/posterior pattern specification
GO:0009966 IDA regulation of signal transduction
GO:0009986 IDA cell surface
GO:0010862 IEA positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0015026 IEA coreceptor activity
GO:0016021 IEA integral component of membrane
GO:0017002 IEA activin-activated receptor activity
GO:0019838 IPI growth factor binding
GO:0023014 IEA signal transduction by phosphorylation
GO:0030165 IPI PDZ domain binding
GO:0030501 IEA positive regulation of bone mineralization
GO:0030509 IMP BMP signaling pathway
GO:0030510 IMP regulation of BMP signaling pathway
GO:0032924 IEA activin receptor signaling pathway
GO:0032927 IEA positive regulation of activin receptor signaling pathway
GO:0034673 IEA inhibin-betaglycan-ActRII complex
GO:0034711 IPI inhibin binding
GO:0042713 IMP sperm ejaculation
GO:0043084 IMP penile erection
GO:0043621 IPI protein self-association
GO:0045648 IEA positive regulation of erythrocyte differentiation
GO:0045669 IEA positive regulation of osteoblast differentiation
GO:0046872 IEA metal ion binding
GO:0048185 IPI activin binding
GO:0048706 IMP embryonic skeletal system development
GO:0050999 IMP regulation of nitric-oxide synthase activity
GO:0060011 IMP Sertoli cell proliferation
GO:0071773 IEA cellular response to BMP stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011188 acvr2aa activin A receptor, type IIAa protein_coding Danio_rerio
ENSDARG00000079944 acvr2ab activin A receptor, type IIAb protein_coding Danio_rerio
ENSG00000121989 ACVR2A activin A receptor, type IIA protein_coding Homo_sapiens

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