C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: actinin alpha 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000052374 Actn2 10090 - 13:12269426-12340760 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000064204 Actn2-001 12269426-12340760 protein_coding
  ENSMUST00000110616 Actn2-002 12308219-12340732 protein_coding
  ENSMUST00000168193 Actn2-201 12269435-12340724 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000064204ENSMUST00000110616ENSMUST00000168193
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000064204 0.074±0.02 0.037±0.02 0.370±0.01 1.736±1.29 9.833±9.64 0.653±0.30 175.253±34.93 1.198±1.13 0.573±1.04 6.668±3.17 117.405±26.09 0.342±0.11 0.056±0.03 0.469±0.05
ENSMUST00000110616 N/A 0.026±0.01 N/A N/A 0.376±0.00 0.456±0.17 N/A N/A 0.078±0.05 4.607±0.00 N/A 0.492±0.06 N/A N/A
ENSMUST00000168193 0.105±0.10 0.036±0.01 0.312±0.00 5.758±0.00 12.993±12.95 0.893±0.43 191.144±54.65 1.991±1.91 0.162±0.19 7.754±1.57 66.366±15.98 0.233±0.09 0.161±0.09 0.340±0.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008J8 CIL_0008J8_0002 VISTA 13:11813964-12415326
CIL_0008J9 CIL_0008J9_0002 VISTA 13:11824772-12428580
CIL_0008IY CIL_0008IY_0002 VISTA 13:11831518-12433920
CIL_00097Y CIL_00097Y_0002 VISTA 13:12065828-12670427

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005865 TAS striated muscle thin filament
GO:0005925 IEA focal adhesion
GO:0006936 IDA muscle contraction
GO:0008092 IDA cytoskeletal protein binding
GO:0030017 IDA sarcomere
GO:0030018 IDA Z disc
GO:0030035 IEA microspike assembly
GO:0030175 IEA filopodium
GO:0030274 IPI LIM domain binding
GO:0030374 IDA ligand-dependent nuclear receptor transcription coactivator activity
GO:0030375 IDA thyroid hormone receptor coactivator activity
GO:0030674 TAS protein binding, bridging
GO:0030864 IEA cortical actin cytoskeleton
GO:0031432 IEA titin binding
GO:0042391 IEA regulation of membrane potential
GO:0042802 IEA identical protein binding
GO:0042803 TAS protein homodimerization activity
GO:0043267 IEA negative regulation of potassium ion transport
GO:0043268 IEA positive regulation of potassium ion transport
GO:0044325 IEA ion channel binding
GO:0046983 IEA protein dimerization activity
GO:0048041 IEA focal adhesion assembly
GO:0051015 IDA actin filament binding
GO:0051289 IEA protein homotetramerization
GO:0051373 IEA FATZ binding
GO:0070062 IEA extracellular vesicular exosome
GO:0070080 IEA titin Z domain binding
GO:1901017 IEA negative regulation of potassium ion transmembrane transporter activity
GO:1901018 IEA positive regulation of potassium ion transmembrane transporter activity
GO:2000009 IEA negative regulation of protein localization to cell surface
GO:2000273 IDA positive regulation of receptor activity
GO:2001141 IDA regulation of RNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000071090 actn2 actinin, alpha 2 protein_coding Danio_rerio
ENSG00000077522 ACTN2 actinin, alpha 2 protein_coding Homo_sapiens

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