C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: muscle, skeletal, receptor tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000057280 Musk 10090 + 4:58285960-58374303 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000081919 Musk-201 58285960-58374302 protein_coding
  ENSMUST00000084578 Musk-002 58285962-58374303 protein_coding
  ENSMUST00000098057 Musk-202 58285962-58374303 protein_coding
  ENSMUST00000098059 Musk-203 58285962-58374302 protein_coding
  ENSMUST00000102893 Musk-001 58285962-58374303 protein_coding
  ENSMUST00000135879 Musk-003 58286175-58304324 processed_transcript
  ENSMUST00000177951 Musk-204 58285962-58374302 protein_coding
  ENSMUST00000179951 Musk-205 58285962-58374302 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENSMUST00000081919ENSMUST00000084578ENSMUST00000098059ENSMUST00000102893ENSMUST00000135879ENSMUST00000177951ENSMUST00000179951
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENSMUST00000081919 0.009±0.00 0.020±0.02 N/A N/A N/A 0.029±0.00 0.035±0.01 0.004±0.00 0.015±0.00 0.045±0.00 N/A 0.080±0.06
ENSMUST00000084578 0.017±0.00 0.048±0.04 0.008±0.00 0.017±0.00 0.512±0.03 0.052±0.02 0.141±0.03 0.017±0.03 0.092±0.08 0.311±0.17 N/A 0.048±0.01
ENSMUST00000098059 N/A N/A N/A N/A N/A 0.015±0.00 0.022±0.00 N/A N/A 0.064±0.03 0.356±0.26 N/A
ENSMUST00000102893 0.041±0.03 0.029±0.02 0.024±0.01 0.169±0.13 0.992±0.28 N/A 0.133±0.00 0.005±0.00 0.167±0.17 0.221±0.16 0.189±0.18 0.073±0.03
ENSMUST00000135879 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.075±0.00 N/A 0.076±0.00
ENSMUST00000177951 N/A N/A N/A N/A 0.282±0.00 0.057±0.00 0.121±0.01 N/A N/A 0.208±0.10 0.042±0.02 N/A
ENSMUST00000179951 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.354±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00016G CIL_00016G_0002 CGP 4:58042442-58374303
CIL_00016H CIL_00016H_0002 CGP 4:58285960-58553898

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0004713 ISS protein tyrosine kinase activity
GO:0004714 TAS transmembrane receptor protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005886 IDA plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006355 IMP regulation of transcription, DNA-templated
GO:0007275 IEA multicellular organismal development
GO:0007528 IGI neuromuscular junction development
GO:0008582 IMP regulation of synaptic growth at neuromuscular junction
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030054 IEA cell junction
GO:0030154 IEA cell differentiation
GO:0030165 IPI PDZ domain binding
GO:0031594 IDA neuromuscular junction
GO:0043113 IMP receptor clustering
GO:0043235 ISO receptor complex
GO:0043525 IMP positive regulation of neuron apoptotic process
GO:0045211 IDA postsynaptic membrane
GO:0071340 IMP skeletal muscle acetylcholine-gated channel clustering
GO:2000541 IMP positive regulation of protein geranylgeranylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000000102 musk muscle, skeletal, receptor tyrosine kinase protein_coding Danio_rerio
ENSG00000030304 MUSK muscle, skeletal, receptor tyrosine kinase protein_coding Homo_sapiens

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