C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: angiotensin II receptor, type 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000068122 Agtr2 10090 + X:21484544-21489164 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000089188 Agtr2-001 21484544-21489164 protein_coding
  ENSMUST00000131150 Agtr2-002 21484722-21486303 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000089188ENSMUST00000131150
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000089188 1.062±0.99 3.131±1.40 0.597±0.08 1.028±0.88 0.167±0.04 0.111±0.03 0.020±0.00 0.101±0.06 0.291±0.40 0.072±0.04 0.013±0.00 0.928±0.49 0.075±0.10 0.099±0.07
ENSMUST00000131150 0.405±0.15 2.873±0.00 N/A N/A N/A 0.772±0.00 N/A N/A N/A N/A N/A N/A 0.217±0.02 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000712 CIL_000712_0002 CGP X:21484544-21742355

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001822 IEA kidney development
GO:0001991 IMP regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0002018 IEA renin-angiotensin regulation of aldosterone production
GO:0002033 IMP vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
GO:0002035 IDA brain renin-angiotensin system
GO:0004945 IDA angiotensin type II receptor activity
GO:0005515 IEA protein binding
GO:0005886 IEA plasma membrane
GO:0006883 IEA cellular sodium ion homeostasis
GO:0006954 IGI inflammatory response
GO:0007166 IEA cell surface receptor signaling pathway
GO:0007199 IDA G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0008134 IEA transcription factor binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0010243 IEA response to organonitrogen compound
GO:0010459 IMP negative regulation of heart rate
GO:0010700 IEA negative regulation of norepinephrine secretion
GO:0016021 IEA integral component of membrane
GO:0017046 IEA peptide hormone binding
GO:0021695 IEA cerebellar cortex development
GO:0032304 IEA negative regulation of icosanoid secretion
GO:0032516 IEA positive regulation of phosphoprotein phosphatase activity
GO:0035556 IDA intracellular signal transduction
GO:0035566 IMP regulation of metanephros size
GO:0035640 IMP exploration behavior
GO:0035815 IEA positive regulation of renal sodium excretion
GO:0035932 IEA aldosterone secretion
GO:0038166 IEA angiotensin-activated signaling pathway
GO:0042416 IEA dopamine biosynthetic process
GO:0042990 IEA regulation of transcription factor import into nucleus
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045909 IEA positive regulation of vasodilation
GO:0048147 IEA negative regulation of fibroblast proliferation
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050715 IEA positive regulation of cytokine secretion
GO:0051000 IDA positive regulation of nitric-oxide synthase activity
GO:0051387 IEA negative regulation of neurotrophin TRK receptor signaling pathway
GO:0060993 IEA kidney morphogenesis
GO:0061049 IEA cell growth involved in cardiac muscle cell development
GO:0071549 IEA cellular response to dexamethasone stimulus
GO:0072300 IMP positive regulation of metanephric glomerulus development
GO:0090190 IMP positive regulation of branching involved in ureteric bud morphogenesis
GO:2001238 IEA positive regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000035552 agtr2 angiotensin II receptor, type 2 protein_coding Danio_rerio
ENSG00000180772 AGTR2 angiotensin II receptor, type 2 protein_coding Homo_sapiens

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