C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000005810 Mthfd2-001 ENSMUSG00000005667 10090 - 6:83305691-83317606 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000005810
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000005810 2.634±0.98 3.082±0.74 1.784±0.41 4.642±2.71 2.803±1.17 2.275±0.53 0.625±0.14 1.295±0.11 14.553±16.37 1.188±0.27 1.634±0.29 4.742±1.78 7.948±3.80 7.434±2.42

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0004477 IBA methenyltetrahydrofolate cyclohydrolase activity
GO:0004487 IBA methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488 IBA methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005615 IEA extracellular space
GO:0005739 IDA mitochondrion
GO:0006730 IBA one-carbon metabolic process
GO:0009396 IEA folic acid-containing compound biosynthetic process
GO:0042301 IEA phosphate ion binding
GO:0046653 IEA tetrahydrofolate metabolic process
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000320415 MTHFD2P5-001 processed_pseudogene Homo_sapiens 0 776
ENST00000394053 MTHFD2-001 protein_coding Homo_sapiens 0 1203
ENST00000409601 MTHFD2-009 protein_coding Homo_sapiens 0 303
ENST00000409804 MTHFD2-003 protein_coding Homo_sapiens 0 435
ENST00000423135 MTHFD2P3-001 processed_pseudogene Homo_sapiens 3.00004e-41 171
ENST00000470592 MTHFD2-007 nonsense_mediated_decay Homo_sapiens 0 870
ENST00000477455 MTHFD2-004 processed_transcript Homo_sapiens 0 307
ENST00000483867 MTHFD2P7-001 processed_pseudogene Homo_sapiens 0 976
ENST00000488086 MTHFD2-005 processed_transcript Homo_sapiens 0 296
ENST00000489041 MTHFD2-008 nonsense_mediated_decay Homo_sapiens 0 737

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