C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: tumor necrosis factor (ligand) superfamily, member 11
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000022592 Tnfsf11-201 ENSMUSG00000022015 10090 - 14:78277445-78308043 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000022592
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000022592 0.135±0.08 0.061±0.04 0.059±0.01 0.043±0.03 0.627±0.45 0.398±0.13 0.016±0.00 0.072±0.04 0.038±0.02 0.064±0.02 0.205±0.00 0.251±0.14 0.014±0.00 0.030±0.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00086P CIL_00086P_0002 VISTA 14:77987851-78589553

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001503 IMP ossification
GO:0002158 IDA osteoclast proliferation
GO:0002548 IEA monocyte chemotaxis
GO:0005125 IEA cytokine activity
GO:0005164 IEA tumor necrosis factor receptor binding
GO:0005515 IPI protein binding
GO:0005615 IEA extracellular space
GO:0005622 IDA intracellular
GO:0005737 IEA cytoplasm
GO:0005886 IEA plasma membrane
GO:0006955 IEA immune response
GO:0007257 IDA activation of JUN kinase activity
GO:0009887 IMP organ morphogenesis
GO:0016021 IEA integral component of membrane
GO:0019221 IEA cytokine-mediated signaling pathway
GO:0030316 IDA osteoclast differentiation
GO:0032813 IPI tumor necrosis factor receptor superfamily binding
GO:0033209 IGI tumor necrosis factor-mediated signaling pathway
GO:0033598 IMP mammary gland epithelial cell proliferation
GO:0034112 IEA positive regulation of homotypic cell-cell adhesion
GO:0042327 IDA positive regulation of phosphorylation
GO:0043123 IDA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406 IEA positive regulation of MAP kinase activity
GO:0045453 IDA bone resorption
GO:0045670 IDA regulation of osteoclast differentiation
GO:0045672 IDA positive regulation of osteoclast differentiation
GO:0045780 IEA positive regulation of bone resorption
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046330 IGI positive regulation of JNK cascade
GO:0048535 TAS lymph node development
GO:0050870 IEA positive regulation of T cell activation
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0051260 IDA protein homooligomerization
GO:0051466 IDA positive regulation of corticotropin-releasing hormone secretion
GO:0051897 IMP positive regulation of protein kinase B signaling
GO:0055074 IGI calcium ion homeostasis
GO:0060749 IMP mammary gland alveolus development
GO:0070371 IDA ERK1 and ERK2 cascade
GO:0071812 IDA positive regulation of fever generation by positive regulation of prostaglandin secretion
GO:0071847 IEA TNFSF11-mediated signaling pathway
GO:0071848 IEA positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
GO:1902533 IEA positive regulation of intracellular signal transduction
GO:2001206 IDA positive regulation of osteoclast development

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000239849 TNFSF11-201 protein_coding Homo_sapiens 0 743
ENST00000358545 TNFSF11-002 protein_coding Homo_sapiens 0 732
ENST00000398795 TNFSF11-001 protein_coding Homo_sapiens 0 1544
ENST00000405262 TNFSF11-202 protein_coding Homo_sapiens 0 1332
ENST00000544862 TNFSF11-203 protein_coding Homo_sapiens 0 695

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