C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000027368 Slc11a1-001 ENSMUSG00000026177 10090 + 1:74375203-74386062 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000027368
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000027368 5.390±1.00 7.979±1.57 3.117±0.20 0.357±0.13 8.493±2.44 2.502±0.55 0.941±0.39 0.623±0.23 4.310±2.49 3.958±0.61 0.438±0.17 4.174±1.71 0.870±1.06 0.359±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00054V CIL_00054V_0002 CGP 1:74362108-74386062
CIL_0005VF CIL_0005VF_0002 CGP 1:74375195-74397285

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000060 IMP protein import into nucleus, translocation
GO:0000165 ISO MAPK cascade
GO:0001818 IMP negative regulation of cytokine production
GO:0001819 IMP positive regulation of cytokine production
GO:0002309 IMP T cell proliferation involved in immune response
GO:0002369 IMP T cell cytokine production
GO:0002606 IMP positive regulation of dendritic cell antigen processing and presentation
GO:0002827 IMP positive regulation of T-helper 1 type immune response
GO:0005384 IMP manganese ion transmembrane transporter activity
GO:0005764 IDA lysosome
GO:0005770 IDA late endosome
GO:0005886 IEA plasma membrane
GO:0006826 IMP iron ion transport
GO:0006828 IMP manganese ion transport
GO:0006876 IEA cellular cadmium ion homeostasis
GO:0006879 IMP cellular iron ion homeostasis
GO:0006909 IMP phagocytosis
GO:0006954 IMP inflammatory response
GO:0007035 IMP vacuolar acidification
GO:0009279 IDA cell outer membrane
GO:0009617 IMP response to bacterium
GO:0010008 IDA endosome membrane
GO:0010628 IMP positive regulation of gene expression
GO:0015707 IDA nitrite transport
GO:0016021 IEA integral component of membrane
GO:0030670 IDA phagocytic vesicle membrane
GO:0032147 IMP activation of protein kinase activity
GO:0032496 ISO response to lipopolysaccharide
GO:0032623 IMP interleukin-2 production
GO:0032632 IMP interleukin-3 production
GO:0032729 IMP positive regulation of interferon-gamma production
GO:0034341 IDA response to interferon-gamma
GO:0042060 IMP wound healing
GO:0042116 IMP macrophage activation
GO:0042742 IMP defense response to bacterium
GO:0042803 IEA protein homodimerization activity
GO:0042832 IMP defense response to protozoan
GO:0043091 IDA L-arginine import
GO:0045342 IMP MHC class II biosynthetic process
GO:0045730 IDA respiratory burst
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046915 IEA transition metal ion transmembrane transporter activity
GO:0048002 IMP antigen processing and presentation of peptide antigen
GO:0048255 IMP mRNA stabilization
GO:0050766 IMP positive regulation of phagocytosis
GO:0050829 IMP defense response to Gram-negative bacterium
GO:0051139 IEA metal ion:proton antiporter activity
GO:0055072 IMP iron ion homeostasis
GO:0060586 IMP multicellular organismal iron ion homeostasis
GO:0070574 IEA cadmium ion transmembrane transport
GO:0070821 IEA tertiary granule membrane
GO:0070839 IDA divalent metal ion export
GO:0071421 IMP manganese ion transmembrane transport

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000233202 SLC11A1-001 protein_coding Homo_sapiens 0 1530
ENST00000354352 SLC11A1-003 nonsense_mediated_decay Homo_sapiens 0 1188
ENST00000460592 SLC11A1-018 retained_intron Homo_sapiens 3e-32 141
ENST00000465984 SLC11A1-004 retained_intron Homo_sapiens 0 1053
ENST00000468221 SLC11A1-009 retained_intron Homo_sapiens 0 928
ENST00000469449 SLC11A1-011 retained_intron Homo_sapiens 0 300
ENST00000469799 SLC11A1-016 retained_intron Homo_sapiens 0 281
ENST00000471875 SLC11A1-015 retained_intron Homo_sapiens 0 283
ENST00000473367 SLC11A1-013 nonsense_mediated_decay Homo_sapiens 0 200
ENST00000475225 SLC11A1-002 retained_intron Homo_sapiens 0 329
ENST00000481524 SLC11A1-014 nonsense_mediated_decay Homo_sapiens 0 366
ENST00000483487 SLC11A1-017 retained_intron Homo_sapiens 0 425
ENST00000490872 SLC11A1-019 retained_intron Homo_sapiens 0 287
ENST00000492413 SLC11A1-006 retained_intron Homo_sapiens 0 481
ENST00000494322 SLC11A1-010 retained_intron Homo_sapiens 0 1127
ENST00000539932 SLC11A1-007 nonsense_mediated_decay Homo_sapiens 0 1072

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