C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: transforming growth factor, beta receptor III
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000031224 Tgfbr3-001 ENSMUSG00000029287 10090 - 5:107106570-107289629 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000031224
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000031224 26.401±2.02 34.605±3.97 23.072±2.43 1.267±0.34 18.926±6.28 4.969±1.39 10.926±0.53 11.938±0.31 2.612±1.08 22.879±0.41 3.066±0.92 18.546±5.31 21.008±5.67 1.736±1.09

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008DI CIL_0008DI_0002 VISTA 5:106921760-107524214
CIL_0008YV CIL_0008YV_0002 VISTA 5:106950899-107552442
CIL_00069I CIL_00069I_0002 CGP 5:106964322-107289629
CIL_0005ZR CIL_0005ZR_0002 CGP 5:107106570-107387058

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001568 IMP blood vessel development
GO:0001666 IEA response to hypoxia
GO:0001701 IMP in utero embryonic development
GO:0001824 IDA blastocyst development
GO:0001837 IEA epithelial to mesenchymal transition
GO:0001889 IMP liver development
GO:0003347 TAS epicardial cell to mesenchymal cell transition
GO:0005024 IMP transforming growth factor beta-activated receptor activity
GO:0005114 IEA type II transforming growth factor beta receptor binding
GO:0005160 IEA transforming growth factor beta receptor binding
GO:0005515 IPI protein binding
GO:0005539 IDA glycosaminoglycan binding
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005615 IEA extracellular space
GO:0005737 IDA cytoplasm
GO:0005783 IDA endoplasmic reticulum
GO:0005887 TAS integral component of plasma membrane
GO:0006461 IEA protein complex assembly
GO:0006955 IEA immune response
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0007181 IEA transforming growth factor beta receptor complex assembly
GO:0008201 IEA heparin binding
GO:0009790 TAS embryo development
GO:0009897 IEA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0010633 IMP negative regulation of epithelial cell migration
GO:0010719 IMP negative regulation of epithelial to mesenchymal transition
GO:0015026 IEA coreceptor activity
GO:0016049 IEA cell growth
GO:0017134 IEA fibroblast growth factor binding
GO:0030165 IPI PDZ domain binding
GO:0030509 IEA BMP signaling pathway
GO:0030511 IEA positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512 IEA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031100 IEA organ regeneration
GO:0032354 IEA response to follicle-stimulating hormone
GO:0034673 IEA inhibin-betaglycan-ActRII complex
GO:0034695 IEA response to prostaglandin E
GO:0034699 IEA response to luteinizing hormone
GO:0035556 IEA intracellular signal transduction
GO:0043393 IEA regulation of protein binding
GO:0046332 IMP SMAD binding
GO:0048185 IEA activin binding
GO:0050431 IDA transforming growth factor beta binding
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0050880 TAS regulation of blood vessel size
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0051271 IEA negative regulation of cellular component movement
GO:0055010 IMP ventricular cardiac muscle tissue morphogenesis
GO:0060021 IMP palate development
GO:0060038 IMP cardiac muscle cell proliferation
GO:0060216 IMP definitive hemopoiesis
GO:0060317 IEA cardiac epithelial to mesenchymal transition
GO:0060318 IMP definitive erythrocyte differentiation
GO:0060347 IMP heart trabecula formation
GO:0060389 IMP pathway-restricted SMAD protein phosphorylation
GO:0060976 TAS coronary vasculature development
GO:0060977 TAS coronary vasculature morphogenesis
GO:0060979 TAS vasculogenesis involved in coronary vascular morphogenesis
GO:0061032 TAS visceral serous pericardium development
GO:0070062 IEA extracellular vesicular exosome
GO:0070123 IEA transforming growth factor beta receptor activity, type III

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000212355 TGFBR3-201 protein_coding Homo_sapiens 0 2529
ENST00000370399 TGFBR3-001 protein_coding Homo_sapiens 0 2466
ENST00000465892 TGFBR3-002 protein_coding Homo_sapiens 0 2473
ENST00000468996 TGFBR3-004 processed_transcript Homo_sapiens 0 562
ENST00000470600 TGFBR3-005 retained_intron Homo_sapiens 0 346
ENST00000525962 TGFBR3-006 protein_coding Homo_sapiens 0 2459
ENST00000529608 TGFBR3-010 retained_intron Homo_sapiens 0 676
ENST00000532540 TGFBR3-008 nonsense_mediated_decay Homo_sapiens 0 2435
ENST00000533089 TGFBR3-007 nonsense_mediated_decay Homo_sapiens 0 1423

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