C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000097981 Cdkn2b-201 ENSMUSG00000073802 10090 - 4:89306289-89311032 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000097981
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000097981 8.787±4.62 9.189±2.96 5.872±1.57 0.381±0.23 8.753±4.62 80.067±5.35 0.370±0.15 3.078±0.64 0.076±0.03 34.219±2.90 0.784±0.14 20.537±7.23 1.646±0.62 3.881±0.53

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007YE CIL_0007YE_0002 VISTA 4:89088208-89693783
CIL_0007U7 CIL_0007U7_0002 VISTA 4:89092538-89696083
CIL_0007YH CIL_0007YH_0002 VISTA 4:89093251-89700067
CIL_0007YG CIL_0007YG_0002 VISTA 4:89099831-89706701
CIL_0007U8 CIL_0007U8_0002 VISTA 4:89105459-89706480
CIL_00095D CIL_00095D_0002 VISTA 4:89105812-89710925
CIL_000945 CIL_000945_0002 VISTA 4:89116711-89721138
CIL_0008WE CIL_0008WE_0002 VISTA 4:89121046-89725353
CIL_0007YC CIL_0007YC_0002 VISTA 4:89125337-89732294
CIL_0008P9 CIL_0008P9_0002 VISTA 4:89126411-89729104
CIL_00099P CIL_00099P_0002 VISTA 4:89127311-89729167
CIL_00099O CIL_00099O_0002 VISTA 4:89131159-89734211
CIL_0008TL CIL_0008TL_0002 VISTA 4:89131716-89739478
CIL_00094Y CIL_00094Y_0002 VISTA 4:89144756-89747133
CIL_0008SY CIL_0008SY_0002 VISTA 4:89146082-89752900
CIL_0008T0 CIL_0008T0_0002 VISTA 4:89152132-89755541
CIL_00085X CIL_00085X_0002 VISTA 4:89155335-89760083
CIL_00094Z CIL_00094Z_0002 VISTA 4:89157896-89760037
CIL_0008GG CIL_0008GG_0002 VISTA 4:89168919-89771433
CIL_00074F CIL_00074F_0002 CGP 4:89306289-89694772

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000079 IEA regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086 IEA G2/M transition of mitotic cell cycle
GO:0001889 IEA liver development
GO:0004861 IEA cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 IEA protein binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0007050 IEA cell cycle arrest
GO:0007093 IEA mitotic cell cycle checkpoint
GO:0007568 IEA aging
GO:0008285 IEA negative regulation of cell proliferation
GO:0014070 IEA response to organic cyclic compound
GO:0019901 IEA protein kinase binding
GO:0030219 IEA megakaryocyte differentiation
GO:0030511 IEA positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030858 IEA positive regulation of epithelial cell differentiation
GO:0031668 IEA cellular response to extracellular stimulus
GO:0031670 IEA cellular response to nutrient
GO:0034097 IEA response to cytokine
GO:0042326 IEA negative regulation of phosphorylation
GO:0048536 IGI spleen development
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0071901 IEA negative regulation of protein serine/threonine kinase activity
GO:2000134 IMP negative regulation of G1/S transition of mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000276925 CDKN2B-001 protein_coding Homo_sapiens 0 394
ENST00000304494 CDKN2A-001 protein_coding Homo_sapiens 0 292
ENST00000498124 CDKN2A-009 protein_coding Homo_sapiens 0 292
ENST00000579122 CDKN2A-014 protein_coding Homo_sapiens 0 292

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