C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: methyl CpG binding protein 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000100750 Mecp2-001 ENSMUSG00000031393 10090 - X:74026592-74085638 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000100750
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000100750 1.084±0.52 1.616±0.93 1.160±0.23 3.266±1.23 1.178±0.52 1.514±0.53 0.725±0.00 0.538±0.11 0.888±0.37 2.095±0.39 1.767±0.48 1.822±1.03 0.554±0.29 0.202±0.13

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007GC CIL_0007GC_0003 CGP X:74013914-74135363
CIL_0001LD CIL_0001LD_0002 CGP X:74026592-74150760

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000792 IDA heterochromatin
GO:0001662 IMP behavioral fear response
GO:0001666 IMP response to hypoxia
GO:0001964 IMP startle response
GO:0001976 IMP neurological system process involved in regulation of systemic arterial blood pressure
GO:0002087 IMP regulation of respiratory gaseous exchange by neurological system process
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IMP sequence-specific DNA binding transcription factor activity
GO:0003729 IDA mRNA binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0006020 IMP inositol metabolic process
GO:0006122 IMP mitochondrial electron transport, ubiquinol to cytochrome c
GO:0006342 IMP chromatin silencing
GO:0006349 IMP regulation of gene expression by genetic imprinting
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IMP regulation of transcription, DNA-templated
GO:0006541 IMP glutamine metabolic process
GO:0006576 IMP cellular biogenic amine metabolic process
GO:0007268 IMP synaptic transmission
GO:0007416 IMP synapse assembly
GO:0007420 IMP brain development
GO:0007585 IMP respiratory gaseous exchange
GO:0007612 IMP learning
GO:0007613 IMP memory
GO:0007616 IMP long-term memory
GO:0008104 IMP protein localization
GO:0008134 IPI transcription factor binding
GO:0008211 IMP glucocorticoid metabolic process
GO:0008284 IMP positive regulation of cell proliferation
GO:0008327 IDA methyl-CpG binding
GO:0008344 IMP adult locomotory behavior
GO:0008542 IMP visual learning
GO:0009405 IMP pathogenesis
GO:0009791 IMP post-embryonic development
GO:0010385 IDA double-stranded methylated DNA binding
GO:0010468 IDA regulation of gene expression
GO:0016358 IMP dendrite development
GO:0016571 IMP histone methylation
GO:0016573 IMP histone acetylation
GO:0019230 IMP proprioception
GO:0019233 IMP sensory perception of pain
GO:0021549 IMP cerebellum development
GO:0021591 IMP ventricular system development
GO:0030182 IMP neuron differentiation
GO:0031061 IMP negative regulation of histone methylation
GO:0031175 IMP neuron projection development
GO:0032048 IMP cardiolipin metabolic process
GO:0033555 IMP multicellular organismal response to stress
GO:0035067 IMP negative regulation of histone acetylation
GO:0035176 IMP social behavior
GO:0035197 IDA siRNA binding
GO:0040029 IMP regulation of gene expression, epigenetic
GO:0042551 IMP neuron maturation
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0046470 IMP phosphatidylcholine metabolic process
GO:0048167 IMP regulation of synaptic plasticity
GO:0050432 IMP catecholamine secretion
GO:0050884 IMP neuromuscular process controlling posture
GO:0050905 IMP neuromuscular process
GO:0051965 IMP positive regulation of synapse assembly
GO:0060079 IMP regulation of excitatory postsynaptic membrane potential
GO:0060291 IMP long-term synaptic potentiation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000303391 MECP2-001 protein_coding Homo_sapiens 0 2874
ENST00000369957 MECP2-003 nonsense_mediated_decay Homo_sapiens 0 337
ENST00000407218 MECP2-005 protein_coding Homo_sapiens 0 826
ENST00000415944 MECP2-008 protein_coding Homo_sapiens 0 353
ENST00000453960 MECP2-002 protein_coding Homo_sapiens 0 2104
ENST00000486506 MECP2-004 processed_transcript Homo_sapiens 0 693
ENST00000611468 MECP2-201 protein_coding Homo_sapiens 0 811
ENST00000619732 MECP2-202 protein_coding Homo_sapiens 0 2848
ENST00000622433 MECP2-203 protein_coding Homo_sapiens 0 1421

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