C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: IL2 inducible T cell kinase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000109237 Itk-004 ENSMUSG00000020395 10090 - 11:46325150-46389493 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainColonKidneyLiverMuscleOvaryPlacentaTestisENSMUST00000109237
Transcript ID Adipose Adrenal Brain Colon Kidney Liver Muscle Ovary Placenta Testis
ENSMUST00000109237 0.049±0.02 0.020±0.01 0.011±0.00 0.223±0.07 0.026±0.01 0.047±0.03 0.007±0.00 0.085±0.07 0.085±0.00 0.007±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00094M CIL_00094M_0002 VISTA 11:45901358-46503267
CIL_00023X CIL_00023X_0002 CGP 11:46325150-46407982

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001816 IMP cytokine production
GO:0001865 IGI NK T cell differentiation
GO:0002250 IMP adaptive immune response
GO:0004715 ISS non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0005911 IDA cell-cell junction
GO:0007202 IMP activation of phospholipase C activity
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0032609 IGI interferon-gamma production
GO:0032633 IGI interleukin-4 production
GO:0035556 IEA intracellular signal transduction
GO:0046872 IEA metal ion binding
GO:0050852 IMP T cell receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000422843 ITK-001 protein_coding Homo_sapiens 0 2204
ENST00000519402 ITK-002 retained_intron Homo_sapiens 0 1110
ENST00000519749 ITK-005 processed_transcript Homo_sapiens 0 582
ENST00000519759 ITK-009 retained_intron Homo_sapiens 0 470
ENST00000520173 ITK-010 retained_intron Homo_sapiens 0 377
ENST00000521769 ITK-008 protein_coding Homo_sapiens 0 459

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