C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: PTK2 protein tyrosine kinase 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000110036 Ptk2-201 ENSMUSG00000022607 10090 - 15:73205105-73423191 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000110036
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000110036 8.384±0.69 4.252±1.12 6.954±2.51 14.392±4.21 3.853±1.19 4.916±2.21 2.519±0.44 4.928±1.43 3.409±1.46 10.675±0.19 4.443±0.79 9.820±3.59 17.411±6.17 3.995±3.20

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002XD CIL_0002XD_0002 CGP 15:73095844-73423191
CIL_0006FQ CIL_0006FQ_0003 CGP 15:73205105-73572242

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000226 IDA microtubule cytoskeleton organization
GO:0001525 IMP angiogenesis
GO:0001568 IMP blood vessel development
GO:0001570 IMP vasculogenesis
GO:0001725 IEA stress fiber
GO:0001764 IDA neuron migration
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0003779 IEA actin binding
GO:0004713 IDA protein tyrosine kinase activity
GO:0004715 ISS non-membrane spanning protein tyrosine kinase activity
GO:0004871 IEA signal transducer activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0005925 IDA focal adhesion
GO:0006928 TAS cellular component movement
GO:0007172 IEA signal complex assembly
GO:0007179 IEA transforming growth factor beta receptor signaling pathway
GO:0007229 ISS integrin-mediated signaling pathway
GO:0008284 IMP positive regulation of cell proliferation
GO:0008360 ISS regulation of cell shape
GO:0008432 IEA JUN kinase binding
GO:0014068 ISS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016324 IDA apical plasma membrane
GO:0018108 ISS peptidyl-tyrosine phosphorylation
GO:0019901 IEA protein kinase binding
GO:0021955 IMP central nervous system neuron axonogenesis
GO:0022408 IEA negative regulation of cell-cell adhesion
GO:0030027 IDA lamellipodium
GO:0030198 IMP extracellular matrix organization
GO:0030335 ISS positive regulation of cell migration
GO:0033628 ISS regulation of cell adhesion mediated by integrin
GO:0040023 IDA establishment of nucleus localization
GO:0042127 ISS regulation of cell proliferation
GO:0042169 IEA SH2 domain binding
GO:0043066 ISS negative regulation of apoptotic process
GO:0043542 IMP endothelial cell migration
GO:0045667 ISS regulation of osteoblast differentiation
GO:0045860 ISS positive regulation of protein kinase activity
GO:0046621 IGI negative regulation of organ growth
GO:0046777 IMP protein autophosphorylation
GO:0048013 ISS ephrin receptor signaling pathway
GO:0050771 IMP negative regulation of axonogenesis
GO:0051897 ISS positive regulation of protein kinase B signaling
GO:0051964 IMP negative regulation of synapse assembly
GO:0060396 IEA growth hormone receptor signaling pathway
GO:2000060 IMP positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000811 IEA negative regulation of anoikis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000142779 ptk2.2-002 protein_coding Danio_rerio 0 207
ENST00000340930 PTK2-011 protein_coding Homo_sapiens 0 3624
ENST00000395218 PTK2-201 protein_coding Homo_sapiens 0 3234
ENST00000430260 PTK2-006 protein_coding Homo_sapiens 0 1386
ENST00000510126 PTK2-022 retained_intron Homo_sapiens 0 244
ENST00000517453 PTK2-043 protein_coding Homo_sapiens 0 595
ENST00000517712 PTK2-004 protein_coding Homo_sapiens 0 606
ENST00000517887 PTK2-008 protein_coding Homo_sapiens 0 4344
ENST00000518173 PTK2-056 retained_intron Homo_sapiens 0 348
ENST00000518509 PTK2-048 processed_transcript Homo_sapiens 0 850
ENST00000519024 PTK2-053 protein_coding Homo_sapiens 0 534
ENST00000519361 PTK2-025 processed_transcript Homo_sapiens 0 316
ENST00000519419 PTK2-007 protein_coding Homo_sapiens 0 4344
ENST00000519465 PTK2-005 protein_coding Homo_sapiens 0 2682
ENST00000519654 PTK2-010 protein_coding Homo_sapiens 0 3232
ENST00000519881 PTK2-037 protein_coding Homo_sapiens 0 612
ENST00000519899 PTK2-023 retained_intron Homo_sapiens 0 486
ENST00000519993 PTK2-013 nonsense_mediated_decay Homo_sapiens 0 3494
ENST00000520045 PTK2-044 protein_coding Homo_sapiens 0 595
ENST00000520151 PTK2-054 protein_coding Homo_sapiens 0 327
ENST00000520460 PTK2-016 processed_transcript Homo_sapiens 0 302
ENST00000520475 PTK2-033 protein_coding Homo_sapiens 0 774
ENST00000520828 PTK2-041 protein_coding Homo_sapiens 0 527
ENST00000520843 PTK2-024 processed_transcript Homo_sapiens 0 267
ENST00000520892 PTK2-038 protein_coding Homo_sapiens 0 612
ENST00000520917 PTK2-021 retained_intron Homo_sapiens 0 732
ENST00000521029 PTK2-051 nonsense_mediated_decay Homo_sapiens 0 566
ENST00000521059 PTK2-057 protein_coding Homo_sapiens 0 4344
ENST00000521172 PTK2-028 processed_transcript Homo_sapiens 0 324
ENST00000521250 PTK2-049 nonsense_mediated_decay Homo_sapiens 0 496
ENST00000521332 PTK2-039 protein_coding Homo_sapiens 0 370
ENST00000521395 PTK2-034 protein_coding Homo_sapiens 0 558
ENST00000521562 PTK2-019 protein_coding Homo_sapiens 0 518
ENST00000521791 PTK2-031 nonsense_mediated_decay Homo_sapiens 0 394
ENST00000521907 PTK2-035 protein_coding Homo_sapiens 0 603
ENST00000521981 PTK2-052 nonsense_mediated_decay Homo_sapiens 0 407
ENST00000521986 PTK2-009 protein_coding Homo_sapiens 0 2603
ENST00000522424 PTK2-047 protein_coding Homo_sapiens 0 521
ENST00000522684 PTK2-001 protein_coding Homo_sapiens 0 4344
ENST00000523067 PTK2-046 nonsense_mediated_decay Homo_sapiens 0 374
ENST00000523388 PTK2-020 protein_coding Homo_sapiens 0 329
ENST00000523435 PTK2-015 protein_coding Homo_sapiens 0 231
ENST00000523474 PTK2-027 processed_transcript Homo_sapiens 0 198
ENST00000523539 PTK2-002 protein_coding Homo_sapiens 0 2808
ENST00000523670 PTK2-050 nonsense_mediated_decay Homo_sapiens 0 377
ENST00000523675 PTK2-036 retained_intron Homo_sapiens 0 372
ENST00000523746 PTK2-026 processed_transcript Homo_sapiens 0 710
ENST00000523803 PTK2-032 protein_coding Homo_sapiens 0 612
ENST00000523805 PTK2-017 processed_transcript Homo_sapiens 0 433
ENST00000524040 PTK2-045 protein_coding Homo_sapiens 0 294
ENST00000524202 PTK2-003 nonsense_mediated_decay Homo_sapiens 0 1513
ENST00000524357 PTK2-055 protein_coding Homo_sapiens 0 372

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