C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: spleen tyrosine kinase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000118756 Syk-003 ENSMUSG00000021457 10090 + 13:52583437-52643614 protein_coding

Expression Patterns

No expression data.

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002JT CIL_0002JT_0002 CGP 13:52504375-52648792
CIL_0002JN CIL_0002JN_0002 CGP 13:52583173-52929681

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000187 IDA activation of MAPK activity
GO:0001820 IMP serotonin secretion
GO:0004713 IDA protein tyrosine kinase activity
GO:0004715 IDA non-membrane spanning protein tyrosine kinase activity
GO:0004716 IDA receptor signaling protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IDA ATP binding
GO:0005737 IEA cytoplasm
GO:0007166 IMP cell surface receptor signaling pathway
GO:0007167 IDA enzyme linked receptor protein signaling pathway
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0007257 IMP activation of JUN kinase activity
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019370 IMP leukotriene biosynthetic process
GO:0019815 IDA B cell receptor complex
GO:0035556 IDA intracellular signal transduction
GO:0043234 IDA protein complex
GO:0043306 IMP positive regulation of mast cell degranulation
GO:0043366 IGI beta selection
GO:0045401 IMP positive regulation of interleukin-3 biosynthetic process
GO:0045425 IMP positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0045579 IMP positive regulation of B cell differentiation
GO:0045588 IMP positive regulation of gamma-delta T cell differentiation
GO:0046638 IGI positive regulation of alpha-beta T cell differentiation
GO:0046641 IGI positive regulation of alpha-beta T cell proliferation
GO:0046777 IDA protein autophosphorylation
GO:0050715 IGI positive regulation of cytokine secretion
GO:0050731 IMP positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850 IMP positive regulation of calcium-mediated signaling
GO:0050853 IDA B cell receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000375746 SYK-002 protein_coding Homo_sapiens 0 979
ENST00000375747 SYK-003 protein_coding Homo_sapiens 0 1731
ENST00000375751 SYK-004 protein_coding Homo_sapiens 0 1731
ENST00000375754 SYK-001 protein_coding Homo_sapiens 0 979

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