C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: fibroblast growth factor receptor 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000122054 Fgfr2-004 ENSMUSG00000030849 10090 - 7:130163709-130266191 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainOvaryPlacentaENSMUST00000122054
Transcript ID Brain Ovary Placenta
ENSMUST00000122054 3.314±0.00 8.791±0.00 8.264±1.46

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002WI CIL_0002WI_0002 CGP 7:129591863-133123350
CIL_0007TN CIL_0007TN_0002 VISTA 7:129759548-130361335
CIL_00095T CIL_00095T_0002 VISTA 7:130125765-130727321
CIL_0001BE CIL_0001BE_0002 CGP 7:130162451-133123350

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0001525 IGI angiogenesis
GO:0001657 IGI ureteric bud development
GO:0001701 IGI in utero embryonic development
GO:0001837 IEA epithelial to mesenchymal transition
GO:0002053 IGI positive regulation of mesenchymal cell proliferation
GO:0003148 IMP outflow tract septum morphogenesis
GO:0003149 IMP membranous septum morphogenesis
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005576 TAS extracellular region
GO:0005634 IDA nucleus
GO:0005737 IEA cytoplasm
GO:0005887 IEA integral component of plasma membrane
GO:0005938 IEA cell cortex
GO:0007267 IMP cell-cell signaling
GO:0007409 IMP axonogenesis
GO:0007528 IMP neuromuscular junction development
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 IGI negative regulation of cell proliferation
GO:0008543 IGI fibroblast growth factor receptor signaling pathway
GO:0008589 IMP regulation of smoothened signaling pathway
GO:0009791 IMP post-embryonic development
GO:0009880 IMP embryonic pattern specification
GO:0009887 IMP organ morphogenesis
GO:0009986 IEA cell surface
GO:0010453 IMP regulation of cell fate commitment
GO:0010518 IEA positive regulation of phospholipase activity
GO:0016331 IMP morphogenesis of embryonic epithelium
GO:0017134 IDA fibroblast growth factor binding
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0022612 IMP gland morphogenesis
GO:0030177 IMP positive regulation of Wnt signaling pathway
GO:0030282 IMP bone mineralization
GO:0030324 IMP lung development
GO:0030855 IMP epithelial cell differentiation
GO:0030901 IGI midbrain development
GO:0030916 IMP otic vesicle formation
GO:0031012 IEA extracellular matrix
GO:0031069 IMP hair follicle morphogenesis
GO:0032808 IMP lacrimal gland development
GO:0035264 IMP multicellular organism growth
GO:0035265 IMP organ growth
GO:0040014 IMP regulation of multicellular organism growth
GO:0040036 IMP regulation of fibroblast growth factor receptor signaling pathway
GO:0042127 IMP regulation of cell proliferation
GO:0042472 IMP inner ear morphogenesis
GO:0042476 IMP odontogenesis
GO:0042803 IEA protein homodimerization activity
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043410 IEA positive regulation of MAPK cascade
GO:0045165 IDA cell fate commitment
GO:0045839 IGI negative regulation of mitosis
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046777 IEA protein autophosphorylation
GO:0048286 IGI lung alveolus development
GO:0048333 IEA mesodermal cell differentiation
GO:0048489 IMP synaptic vesicle transport
GO:0048557 IMP embryonic digestive tract morphogenesis
GO:0048562 IMP embryonic organ morphogenesis
GO:0048565 IMP digestive tract development
GO:0048568 IMP embryonic organ development
GO:0048608 IMP reproductive structure development
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0048701 IEA embryonic cranial skeleton morphogenesis
GO:0048730 IMP epidermis morphogenesis
GO:0048755 IMP branching morphogenesis of a nerve
GO:0048762 IGI mesenchymal cell differentiation
GO:0050673 IMP epithelial cell proliferation
GO:0050678 IMP regulation of epithelial cell proliferation
GO:0050679 IGI positive regulation of epithelial cell proliferation
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0051150 IMP regulation of smooth muscle cell differentiation
GO:0051781 IMP positive regulation of cell division
GO:0055010 IMP ventricular cardiac muscle tissue morphogenesis
GO:0060045 IGI positive regulation of cardiac muscle cell proliferation
GO:0060174 IMP limb bud formation
GO:0060348 IMP bone development
GO:0060349 IMP bone morphogenesis
GO:0060365 IMP coronal suture morphogenesis
GO:0060441 IMP epithelial tube branching involved in lung morphogenesis
GO:0060442 IMP branching involved in prostate gland morphogenesis
GO:0060445 IMP branching involved in salivary gland morphogenesis
GO:0060449 IMP bud elongation involved in lung branching
GO:0060463 IMP lung lobe morphogenesis
GO:0060484 IMP lung-associated mesenchyme development
GO:0060501 IMP positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060512 IMP prostate gland morphogenesis
GO:0060523 IMP prostate epithelial cord elongation
GO:0060527 IMP prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060529 IMP squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0060595 IMP fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0060601 IMP lateral sprouting from an epithelium
GO:0060615 IMP mammary gland bud formation
GO:0060664 IGI epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060667 IGI branch elongation involved in salivary gland morphogenesis
GO:0060670 IMP branching involved in labyrinthine layer morphogenesis
GO:0060687 IMP regulation of branching involved in prostate gland morphogenesis
GO:0060688 IMP regulation of morphogenesis of a branching structure
GO:0060915 IGI mesenchymal cell differentiation involved in lung development
GO:0060916 IMP mesenchymal cell proliferation involved in lung development
GO:0061031 IMP endodermal digestive tract morphogenesis
GO:0070307 IGI lens fiber cell development
GO:0070372 IMP regulation of ERK1 and ERK2 cascade
GO:0070374 IGI positive regulation of ERK1 and ERK2 cascade
GO:0090263 IMP positive regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000080916 fgfr2-202 protein_coding Danio_rerio 0 1009
ENSDART00000149125 fgfr2-002 protein_coding Danio_rerio 0 1009
ENSDART00000098269 fgfr2-003 protein_coding Danio_rerio 0 998
ENSDART00000150061 fgfr2-005 protein_coding Danio_rerio 0 976
ENSDART00000080914 fgfr2-201 protein_coding Danio_rerio 0 689
ENSDART00000149602 fgfr2-004 protein_coding Danio_rerio 0 688
ENSDART00000067689 fgfr1b-201 protein_coding Danio_rerio 0 462
ENSDART00000075259 fgfr1b-202 protein_coding Danio_rerio 0 451
ENSDART00000125883 fgfr3-202 protein_coding Danio_rerio 0 449
ENSDART00000013534 fgfr3-201 protein_coding Danio_rerio 0 449
ENST00000292408 FGFR4-001 protein_coding Homo_sapiens 9e-33 147
ENST00000326324 FGFR1-008 protein_coding Homo_sapiens 0 889
ENST00000335922 FGFR1-003 protein_coding Homo_sapiens 0 856
ENST00000336553 FGFR2-003 protein_coding Homo_sapiens 0 2558
ENST00000346997 FGFR2-009 protein_coding Homo_sapiens 0 3380
ENST00000351936 FGFR2-201 protein_coding Homo_sapiens 0 3352
ENST00000356207 FGFR1-004 protein_coding Homo_sapiens 0 889
ENST00000356226 FGFR2-012 protein_coding Homo_sapiens 0 2905
ENST00000357555 FGFR2-202 protein_coding Homo_sapiens 0 2632
ENST00000358487 FGFR2-001 protein_coding Homo_sapiens 0 3707
ENST00000359354 FGFR2-016 protein_coding Homo_sapiens 0 1112
ENST00000360144 FGFR2-004 protein_coding Homo_sapiens 0 2276
ENST00000369056 FGFR2-006 protein_coding Homo_sapiens 0 2856
ENST00000369058 FGFR2-011 protein_coding Homo_sapiens 0 2957
ENST00000369059 FGFR2-007 protein_coding Homo_sapiens 0 2588
ENST00000369060 FGFR2-005 protein_coding Homo_sapiens 0 1783
ENST00000369061 FGFR2-203 protein_coding Homo_sapiens 0 2071
ENST00000393637 FGFR4-002 protein_coding Homo_sapiens 7e-33 147
ENST00000393648 FGFR4-003 protein_coding Homo_sapiens 8e-33 147
ENST00000397091 FGFR1-001 protein_coding Homo_sapiens 0 889
ENST00000397103 FGFR1-011 protein_coding Homo_sapiens 0 682
ENST00000397108 FGFR1-020 protein_coding Homo_sapiens 0 889
ENST00000397113 FGFR1-012 protein_coding Homo_sapiens 0 889
ENST00000425967 FGFR1-202 protein_coding Homo_sapiens 0 889
ENST00000429361 FGFR2-021 protein_coding Homo_sapiens 0 1341
ENST00000447712 FGFR1-203 protein_coding Homo_sapiens 0 889
ENST00000457416 FGFR2-010 protein_coding Homo_sapiens 0 3184
ENST00000463870 FGFR2-023 processed_transcript Homo_sapiens 0 385
ENST00000467584 FGFR2-020 processed_transcript Homo_sapiens 0 305
ENST00000478859 FGFR2-008 protein_coding Homo_sapiens 0 2597
ENST00000490349 FGFR2-015 processed_transcript Homo_sapiens 0 1380
ENST00000491111 FGFR2-013 processed_transcript Homo_sapiens 0 298
ENST00000491475 FGFR2-022 retained_intron Homo_sapiens 0 472
ENST00000502906 FGFR4-004 protein_coding Homo_sapiens 8e-33 147
ENST00000508139 FGFR4-013 retained_intron Homo_sapiens 1e-16 92
ENST00000509511 FGFR4-007 retained_intron Homo_sapiens 4e-33 147
ENST00000526570 FGFR1-024 retained_intron Homo_sapiens 0 889
ENST00000527114 FGFR1-025 retained_intron Homo_sapiens 0 392
ENST00000531196 FGFR1-039 nonsense_mediated_decay Homo_sapiens 0 350
ENST00000532791 FGFR1-002 protein_coding Homo_sapiens 0 856
ENST00000533619 FGFR1-030 retained_intron Homo_sapiens 0 315
ENST00000604236 FGFR2-024 nonsense_mediated_decay Homo_sapiens 0 2331
ENST00000611527 FGFR2-026 protein_coding Homo_sapiens 0 270
ENST00000613048 FGFR2-204 protein_coding Homo_sapiens 0 3025
ENST00000613324 FGFR2-025 protein_coding Homo_sapiens 0 560

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