C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: signal transducer and activator of transcription 3
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000127638 Stat3-001 ENSMUSG00000004040 10090 - 11:100886810-100939540 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000127638
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000127638 50.506±9.86 33.126±4.60 37.966±2.78 7.446±2.50 66.547±3.28 53.748±7.17 40.185±2.67 23.558±2.54 22.982±7.11 73.355±2.03 6.506±2.01 54.159±16.79 18.338±8.30 8.311±3.74

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006I7 CIL_0006I7_0002 CGP 11:100780731-100885169
CIL_0006IK CIL_0006IK_0002 CGP 11:100859351-100939540
CIL_00046I CIL_00046I_0002 CGP 11:100885098-100970887

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000981 IDA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001103 IEA RNA polymerase II repressing transcription factor binding
GO:0001659 IMP temperature homeostasis
GO:0001754 IMP eye photoreceptor cell differentiation
GO:0003677 IDA DNA binding
GO:0004871 IEA signal transducer activity
GO:0004879 IEA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005743 IEA mitochondrial inner membrane
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006355 NAS regulation of transcription, DNA-templated
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006606 ISS protein import into nucleus
GO:0006953 IEA acute-phase response
GO:0007259 TAS JAK-STAT cascade
GO:0008134 ISS transcription factor binding
GO:0008283 IDA cell proliferation
GO:0008285 IGI negative regulation of cell proliferation
GO:0010033 IEA response to organic substance
GO:0014070 IEA response to organic cyclic compound
GO:0016310 IDA phosphorylation
GO:0019221 NAS cytokine-mediated signaling pathway
GO:0019827 IMP stem cell maintenance
GO:0019901 IPI protein kinase binding
GO:0019903 IEA protein phosphatase binding
GO:0019953 IMP sexual reproduction
GO:0030522 IEA intracellular receptor signaling pathway
GO:0031730 IEA CCR5 chemokine receptor binding
GO:0032355 IEA response to estradiol
GO:0032870 IEA cellular response to hormone stimulus
GO:0034097 IEA response to cytokine
GO:0035259 IEA glucocorticoid receptor binding
GO:0040014 IMP regulation of multicellular organism growth
GO:0042493 IEA response to drug
GO:0042593 IMP glucose homeostasis
GO:0042755 IMP eating behavior
GO:0043434 IEA response to peptide hormone
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045471 IEA response to ethanol
GO:0045747 IMP positive regulation of Notch signaling pathway
GO:0045820 IMP negative regulation of glycolytic process
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046983 IPI protein dimerization activity
GO:0048708 IMP astrocyte differentiation
GO:0060019 IMP radial glial cell differentiation
GO:0060396 IEA growth hormone receptor signaling pathway
GO:0060397 IDA JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060548 IEA negative regulation of cell death
GO:0070102 ISS interleukin-6-mediated signaling pathway
GO:2001223 IGI negative regulation of neuron migration

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000080854 stat3-002 protein_coding Danio_rerio 0 1530
ENSDART00000104519 stat3-001 protein_coding Danio_rerio 0 1530
ENST00000264657 STAT3-001 protein_coding Homo_sapiens 0 3526
ENST00000361099 STAT1-001 protein_coding Homo_sapiens 0.0000000000001 84
ENST00000389272 STAT3-013 protein_coding Homo_sapiens 0 3201
ENST00000392322 STAT1-003 protein_coding Homo_sapiens 0.00000000000006 84
ENST00000392323 STAT1-002 protein_coding Homo_sapiens 0.00000000000006 84
ENST00000404395 STAT3-002 protein_coding Homo_sapiens 0 3332
ENST00000409465 STAT1-011 protein_coding Homo_sapiens 0.00000000000007 84
ENST00000452281 STAT1-006 nonsense_mediated_decay Homo_sapiens 0.00000000000006 84
ENST00000462269 STAT3-006 retained_intron Homo_sapiens 0 453
ENST00000471989 STAT3-005 retained_intron Homo_sapiens 0 379
ENST00000478276 STAT3-003 retained_intron Homo_sapiens 5e-34 147
ENST00000491272 STAT3-007 retained_intron Homo_sapiens 0 462
ENST00000498330 STAT3-004 retained_intron Homo_sapiens 0 617
ENST00000540176 STAT1-201 protein_coding Homo_sapiens 0.0000000000001 84
ENST00000585360 STAT3-017 retained_intron Homo_sapiens 0 483
ENST00000585517 STAT3-012 protein_coding Homo_sapiens 0 2911
ENST00000588969 STAT3-011 protein_coding Homo_sapiens 0 3365

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