C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: vascular endothelial growth factor A
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000142351 Vegfa-003 ENSMUSG00000023951 10090 - 17:46018543-46032369 protein_coding

Mus musculus EnsemblGRCm38

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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBreastColonKidneyLiverMuscleOvaryPlacentaTestisENSMUST00000142351
Transcript ID Adipose Adrenal Breast Colon Kidney Liver Muscle Ovary Placenta Testis
ENSMUST00000142351 32.075±5.62 87.960±28.06 27.943±2.15 9.259±2.13 22.612±0.53 4.921±0.00 20.361±2.97 18.761±3.72 15.958±11.84 1.108±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008YI CIL_0008YI_0002 VISTA 17:45708824-46310190
CIL_00049T CIL_00049T_0002 CGP 17:46016993-46128910

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001525 IDA angiogenesis
GO:0001541 IMP ovarian follicle development
GO:0001568 IMP blood vessel development
GO:0001569 IMP patterning of blood vessels
GO:0001666 ISS response to hypoxia
GO:0001701 IMP in utero embryonic development
GO:0001822 IMP kidney development
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0001938 ISO positive regulation of endothelial cell proliferation
GO:0001944 IMP vasculature development
GO:0001968 ISS fibronectin binding
GO:0002040 IDA sprouting angiogenesis
GO:0002042 ISS cell migration involved in sprouting angiogenesis
GO:0002052 IGI positive regulation of neuroblast proliferation
GO:0002053 IDA positive regulation of mesenchymal cell proliferation
GO:0002092 ISS positive regulation of receptor internalization
GO:0002575 IEA basophil chemotaxis
GO:0003007 IMP heart morphogenesis
GO:0003151 IMP outflow tract morphogenesis
GO:0003169 IMP coronary vein morphogenesis
GO:0005102 IDA receptor binding
GO:0005125 ISS cytokine activity
GO:0005161 ISS platelet-derived growth factor receptor binding
GO:0005172 ISS vascular endothelial growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005576 IDA extracellular region
GO:0005615 IDA extracellular space
GO:0005737 IDA cytoplasm
GO:0005886 IEA plasma membrane
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0007498 IMP mesoderm development
GO:0007595 IMP lactation
GO:0008083 IDA:ISS growth factor activity
GO:0008201 IDA:ISS heparin binding
GO:0008283 IMP cell proliferation
GO:0008284 IDA positive regulation of cell proliferation
GO:0008360 ISS regulation of cell shape
GO:0009986 ISS cell surface
GO:0010595 ISS positive regulation of endothelial cell migration
GO:0010628 IEA positive regulation of gene expression
GO:0016020 IEA membrane
GO:0016477 IDA cell migration
GO:0022408 IGI negative regulation of cell-cell adhesion
GO:0030141 ISS secretory granule
GO:0030224 ISS monocyte differentiation
GO:0030225 ISS macrophage differentiation
GO:0030324 IMP lung development
GO:0030335 IEA positive regulation of cell migration
GO:0030823 ISO regulation of cGMP metabolic process
GO:0030855 IMP epithelial cell differentiation
GO:0030949 ISS positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031077 IMP post-embryonic camera-type eye development
GO:0031334 ISS positive regulation of protein complex assembly
GO:0031954 ISS positive regulation of protein autophosphorylation
GO:0032147 ISS activation of protein kinase activity
GO:0032793 ISS positive regulation of CREB transcription factor activity
GO:0033138 ISS positive regulation of peptidyl-serine phosphorylation
GO:0035148 ISS tube formation
GO:0035767 ISS endothelial cell chemotaxis
GO:0035924 ISS cellular response to vascular endothelial growth factor stimulus
GO:0036303 IMP lymph vessel morphogenesis
GO:0038033 ISS positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0038084 IDA vascular endothelial growth factor signaling pathway
GO:0038091 ISS positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0038190 IMP VEGF-activated neuropilin signaling pathway
GO:0038191 IEA neuropilin binding
GO:0040007 IMP growth
GO:0042056 ISS chemoattractant activity
GO:0042462 IMP eye photoreceptor cell development
GO:0042802 IEA identical protein binding
GO:0043066 IMP:ISS negative regulation of apoptotic process
GO:0043117 IDA positive regulation of vascular permeability
GO:0043129 IMP surfactant homeostasis
GO:0043154 IEA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043183 IDA:ISS vascular endothelial growth factor receptor 1 binding
GO:0043184 IPI:ISS vascular endothelial growth factor receptor 2 binding
GO:0043406 ISS positive regulation of MAP kinase activity
GO:0043524 IDA negative regulation of neuron apoptotic process
GO:0043536 ISS positive regulation of blood vessel endothelial cell migration
GO:0045766 IDA:ISS positive regulation of angiogenesis
GO:0045785 ISS positive regulation of cell adhesion
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046982 ISO protein heterodimerization activity
GO:0048010 IDA vascular endothelial growth factor receptor signaling pathway
GO:0048018 ISS receptor agonist activity
GO:0048469 IMP cell maturation
GO:0048514 IDA blood vessel morphogenesis
GO:0048593 IMP camera-type eye morphogenesis
GO:0048666 IMP neuron development
GO:0048739 IMP cardiac muscle fiber development
GO:0048754 IDA branching morphogenesis of an epithelial tube
GO:0048842 IDA positive regulation of axon extension involved in axon guidance
GO:0048844 IMP artery morphogenesis
GO:0050679 IMP positive regulation of epithelial cell proliferation
GO:0050731 ISS positive regulation of peptidyl-tyrosine phosphorylation
GO:0050840 IDA extracellular matrix binding
GO:0050918 IDA positive chemotaxis
GO:0050927 ISS positive regulation of positive chemotaxis
GO:0051272 ISS positive regulation of cellular component movement
GO:0051781 IEA positive regulation of cell division
GO:0051894 ISS positive regulation of focal adhesion assembly
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0060319 IMP primitive erythrocyte differentiation
GO:0060426 IDA lung vasculature development
GO:0060749 IMP mammary gland alveolus development
GO:0060754 IEA positive regulation of mast cell chemotaxis
GO:0060948 IMP cardiac vascular smooth muscle cell development
GO:0060982 IMP coronary artery morphogenesis
GO:0061419 IEA positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0071456 ISO:ISS cellular response to hypoxia
GO:0071542 IGI dopaminergic neuron differentiation
GO:0071679 IDA commissural neuron axon guidance
GO:0090037 ISS positive regulation of protein kinase C signaling
GO:0090050 ISS positive regulation of cell migration involved in sprouting angiogenesis
GO:0090190 IDA positive regulation of branching involved in ureteric bud morphogenesis
GO:0090259 IDA regulation of retinal ganglion cell axon guidance
GO:1900086 ISS positive regulation of peptidyl-tyrosine autophosphorylation
GO:1900745 IEA positive regulation of p38MAPK cascade
GO:1901492 IDA positive regulation of lymphangiogenesis
GO:1901727 IEA positive regulation of histone deacetylase activity
GO:1902336 IMP positive regulation of retinal ganglion cell axon guidance
GO:1902533 ISS positive regulation of intracellular signal transduction
GO:1902966 IEA positive regulation of protein localization to early endosome
GO:2001237 IDA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000230480 VEGFA-009 protein_coding Homo_sapiens 0 568
ENST00000324450 VEGFA-011 protein_coding Homo_sapiens 0 1072
ENST00000372055 VEGFA-004 protein_coding Homo_sapiens 0 1214
ENST00000372064 VEGFA-002 protein_coding Homo_sapiens 0 1099
ENST00000372067 VEGFA-001 protein_coding Homo_sapiens 0 1419
ENST00000372077 VEGFA-019 protein_coding Homo_sapiens 0 1000
ENST00000413642 VEGFA-012 protein_coding Homo_sapiens 0 1404
ENST00000417285 VEGFA-014 protein_coding Homo_sapiens 0 1098
ENST00000425836 VEGFA-003 protein_coding Homo_sapiens 0 1783
ENST00000457104 VEGFA-022 protein_coding Homo_sapiens 0 462
ENST00000476772 VEGFA-005 retained_intron Homo_sapiens 0 1391
ENST00000480614 VEGFA-007 retained_intron Homo_sapiens 0 370
ENST00000482630 VEGFA-013 protein_coding Homo_sapiens 0 1098
ENST00000493786 VEGFA-010 retained_intron Homo_sapiens 0 261
ENST00000497139 VEGFA-008 retained_intron Homo_sapiens 0 346
ENST00000512683 VEGFA-006 retained_intron Homo_sapiens 0 340
ENST00000518538 VEGFA-017 retained_intron Homo_sapiens 0 606
ENST00000518689 VEGFA-023 protein_coding Homo_sapiens 0 761
ENST00000518824 VEGFA-024 protein_coding Homo_sapiens 0 488
ENST00000519767 VEGFA-015 protein_coding Homo_sapiens 0 1101
ENST00000520265 VEGFA-016 protein_coding Homo_sapiens 0 237
ENST00000520948 VEGFA-020 protein_coding Homo_sapiens 0 1371
ENST00000523125 VEGFA-025 protein_coding Homo_sapiens 0 488
ENST00000523873 VEGFA-021 protein_coding Homo_sapiens 0 669
ENST00000523950 VEGFA-018 protein_coding Homo_sapiens 0 568
ENST00000611736 VEGFA-201 protein_coding Homo_sapiens 0 1535
ENST00000615393 VEGFA-202 protein_coding Homo_sapiens 0 1421
ENST00000617771 VEGFA-203 protein_coding Homo_sapiens 0 1393
ENST00000621747 VEGFA-204 protein_coding Homo_sapiens 0 1419

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