C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: adrenergic receptor, alpha 1a
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000159068 Adra1a-004 ENSMUSG00000045875 10090 + 14:66635341-66729984 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderLiverMuscleOvaryPlacentaTestisENSMUST00000159068
Transcript ID Adrenal Bladder Liver Muscle Ovary Placenta Testis
ENSMUST00000159068 0.559±0.11 0.005±0.00 0.040±0.07 0.105±0.00 0.018±0.00 0.011±0.00 0.049±0.03

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001985 IMP negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001994 IMP norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001996 IGI positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997 IGI positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0003084 IEA positive regulation of systemic arterial blood pressure
GO:0004937 ISO alpha1-adrenergic receptor activity
GO:0005634 ISS nucleus
GO:0005886 IEA plasma membrane
GO:0007200 IDA phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007202 IEA activation of phospholipase C activity
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007512 IGI adult heart development
GO:0007568 IEA aging
GO:0009725 IEA response to hormone
GO:0010460 IEA positive regulation of heart rate
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016049 IGI cell growth
GO:0030018 IEA Z disc
GO:0030315 IEA T-tubule
GO:0031965 ISS nuclear membrane
GO:0032230 IEA positive regulation of synaptic transmission, GABAergic
GO:0035024 ISO negative regulation of Rho protein signal transduction
GO:0035265 IGI organ growth
GO:0042493 IEA response to drug
GO:0043410 IGI positive regulation of MAPK cascade
GO:0045760 IEA positive regulation of action potential
GO:0045907 IEA positive regulation of vasoconstriction
GO:0045987 IDA positive regulation of smooth muscle contraction
GO:0046982 ISS protein heterodimerization activity
GO:0060073 IEA micturition
GO:0060402 IEA calcium ion transport into cytosol
GO:0060452 IEA positive regulation of cardiac muscle contraction
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0071875 IEA adrenergic receptor signaling pathway
GO:0090037 IEA positive regulation of protein kinase C signaling
GO:0097195 IDA pilomotor reflex

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000276393 ADRA1A-003 protein_coding Homo_sapiens 0 1676
ENST00000354550 ADRA1A-002 protein_coding Homo_sapiens 0 1478
ENST00000380572 ADRA1A-005 protein_coding Homo_sapiens 0 1085
ENST00000380573 ADRA1A-008 protein_coding Homo_sapiens 0 1676
ENST00000380582 ADRA1A-001 protein_coding Homo_sapiens 0 1511
ENST00000380586 ADRA1A-004 protein_coding Homo_sapiens 0 1509
ENST00000518621 ADRA1A-011 processed_transcript Homo_sapiens 0 501
ENST00000519096 ADRA1A-007 nonsense_mediated_decay Homo_sapiens 0 1088
ENST00000519229 ADRA1A-009 protein_coding Homo_sapiens 0 1448
ENST00000521711 ADRA1A-006 nonsense_mediated_decay Homo_sapiens 0 1088

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