C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: neural precursor cell expressed, developmentally down-regulated gene 4-like
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000163516 Nedd4l-202 ENSMUSG00000024589 10090 + 18:64887756-65217826 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000163516
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000163516 2.563±1.19 1.359±0.40 2.353±0.65 6.559±0.57 1.833±0.59 5.369±0.58 0.663±0.06 4.836±0.57 0.412±0.17 3.860±1.13 0.576±0.01 1.803±0.31 1.645±0.93 0.207±0.05

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006OF CIL_0006OF_0002 CGP 18:64528979-65217826
CIL_0002BK CIL_0002BK_0002 CGP 18:64887756-65393888

Gene Ontology

GO IDEvidence TypeGO Description
GO:0003085 IMP negative regulation of systemic arterial blood pressure
GO:0003254 IEA regulation of membrane depolarization
GO:0004842 IBA ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005634 IBA nucleus
GO:0005737 IBA cytoplasm
GO:0005886 IEA plasma membrane
GO:0006513 IEA protein monoubiquitination
GO:0009651 IMP response to salt stress
GO:0010038 IEA response to metal ion
GO:0010765 IGI positive regulation of sodium ion transport
GO:0010766 IDA negative regulation of sodium ion transport
GO:0015459 IEA potassium channel regulator activity
GO:0016874 IEA ligase activity
GO:0017080 IEA sodium channel regulator activity
GO:0019870 IEA potassium channel inhibitor activity
GO:0019871 IDA sodium channel inhibitor activity
GO:0034765 IEA regulation of ion transmembrane transport
GO:0042391 IEA regulation of membrane potential
GO:0042787 IBA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 IEA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043162 IDA ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0044325 IEA ion channel binding
GO:0045732 IEA positive regulation of protein catabolic process
GO:0060306 IEA regulation of membrane repolarization
GO:0070062 IEA extracellular vesicular exosome
GO:0070936 IEA protein K48-linked ubiquitination
GO:0086005 IEA ventricular cardiac muscle cell action potential
GO:1901016 IEA regulation of potassium ion transmembrane transporter activity
GO:1901017 IEA negative regulation of potassium ion transmembrane transporter activity
GO:1901380 IEA negative regulation of potassium ion transmembrane transport
GO:1902306 IEA negative regulation of sodium ion transmembrane transport
GO:2000009 IEA negative regulation of protein localization to cell surface
GO:2000650 IEA negative regulation of sodium ion transmembrane transporter activity
GO:2000810 IDA regulation of tight junction assembly
GO:2001259 IGI positive regulation of cation channel activity
GO:2001288 IEA positive regulation of caveolin-mediated endocytosis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000256830 NEDD4L-037 protein_coding Homo_sapiens 0 2204
ENST00000356462 NEDD4L-005 protein_coding Homo_sapiens 0 2383
ENST00000357895 NEDD4L-003 protein_coding Homo_sapiens 0 4032
ENST00000382850 NEDD4L-002 protein_coding Homo_sapiens 0 3162
ENST00000400345 NEDD4L-001 protein_coding Homo_sapiens 0 4128
ENST00000431212 NEDD4L-014 protein_coding Homo_sapiens 0 3731
ENST00000435432 NEDD4L-017 protein_coding Homo_sapiens 0 2564
ENST00000456173 NEDD4L-013 protein_coding Homo_sapiens 0 3162
ENST00000456986 NEDD4L-201 protein_coding Homo_sapiens 0 4399
ENST00000585363 NEDD4L-008 processed_transcript Homo_sapiens 5.60519e-45 183
ENST00000585594 NEDD4L-010 processed_transcript Homo_sapiens 0.00000000000002 82
ENST00000585970 NEDD4L-041 processed_transcript Homo_sapiens 0 412
ENST00000586263 NEDD4L-004 protein_coding Homo_sapiens 0 2593
ENST00000586268 NEDD4L-024 protein_coding Homo_sapiens 0 555
ENST00000587190 NEDD4L-016 protein_coding Homo_sapiens 0 375
ENST00000587547 NEDD4L-011 processed_transcript Homo_sapiens 0.0000000000003 81
ENST00000587634 NEDD4L-023 processed_transcript Homo_sapiens 0 394
ENST00000587881 NEDD4L-030 protein_coding Homo_sapiens 0 1772
ENST00000588066 NEDD4L-018 processed_transcript Homo_sapiens 0 593
ENST00000588494 NEDD4L-019 protein_coding Homo_sapiens 0 442
ENST00000588516 NEDD4L-009 processed_transcript Homo_sapiens 1.4013e-45 187
ENST00000588712 NEDD4L-034 retained_intron Homo_sapiens 0 689
ENST00000589054 NEDD4L-022 protein_coding Homo_sapiens 0 725
ENST00000590020 NEDD4L-026 retained_intron Homo_sapiens 0 612
ENST00000590248 NEDD4L-036 retained_intron Homo_sapiens 0 514
ENST00000590506 NEDD4L-035 retained_intron Homo_sapiens 0 1094
ENST00000590638 NEDD4L-028 retained_intron Homo_sapiens 0 1116
ENST00000590694 NEDD4L-007 processed_transcript Homo_sapiens 1e-23 111
ENST00000591579 NEDD4L-006 processed_transcript Homo_sapiens 2e-16 88
ENST00000591989 NEDD4L-039 processed_transcript Homo_sapiens 9.99995e-41 169
ENST00000592097 NEDD4L-033 retained_intron Homo_sapiens 0 656
ENST00000592601 NEDD4L-025 processed_transcript Homo_sapiens 0 647
ENST00000592846 NEDD4L-020 protein_coding Homo_sapiens 0 364
ENST00000617539 NEDD4L-042 protein_coding Homo_sapiens 5e-20 102

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