C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: argonaute RISC catalytic component 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000220592 AGO2-001 ENSG00000123908 9606 - 8:140531165-140635619 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000220592
Transcript ID Bladder Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000220592 1.756±0.00 1.108±0.00 4.967±0.00 1.678±0.00 0.689±0.14 3.574±0.00 2.501±0.00 6.202±0.00 3.182±1.95 0.818±0.39 0.789±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002XO CIL_0002XO_0001 CGP 8:140511298-140635619
CIL_0002XD CIL_0002XD_0001 CGP 8:140531165-141002216

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000340 IDA RNA 7-methylguanosine cap binding
GO:0000932 IDA cytoplasmic mRNA processing body
GO:0003676 IEA nucleic acid binding
GO:0003723 IEA RNA binding
GO:0003729 IEA mRNA binding
GO:0003743 NAS translation initiation factor activity
GO:0004521 EXP endoribonuclease activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005844 IDA polysome
GO:0005845 IDA mRNA cap binding complex
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006379 IEA mRNA cleavage
GO:0006412 NAS translation
GO:0006413 NAS translational initiation
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007219 TAS Notch signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009791 IEA post-embryonic development
GO:0010467 TAS gene expression
GO:0010586 IEA miRNA metabolic process
GO:0010628 IEA positive regulation of gene expression
GO:0016020 IDA membrane
GO:0016442 IDA RISC complex
GO:0030529 IDA ribonucleoprotein complex
GO:0031047 ISS gene silencing by RNA
GO:0031054 IDA pre-miRNA processing
GO:0035068 IDA micro-ribonucleoprotein complex
GO:0035197 IDA siRNA binding
GO:0035198 IEA miRNA binding
GO:0035278 IDA negative regulation of translation involved in gene silencing by miRNA
GO:0035279 IDA mRNA cleavage involved in gene silencing by miRNA
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0044822 IDA poly(A) RNA binding
GO:0045087 TAS innate immune response
GO:0045947 IDA negative regulation of translational initiation
GO:0046872 IEA metal ion binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0060213 ISS positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0070551 IDA endoribonuclease activity, cleaving siRNA-paired mRNA
GO:0090502 IEA RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900153 ISS positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000044113 Ago2-001 protein_coding Mus_musculus 0 3884
ENSMUST00000117257 Gm6088-001 processed_pseudogene Mus_musculus 0 2582
ENSMUST00000097888 Ago1-001 protein_coding Mus_musculus 0 1395
ENSMUST00000127800 Ago1-002 nonsense_mediated_decay Mus_musculus 0 1258
ENSDART00000083777 protein_coding Danio_rerio 0 1205
ENSMUST00000176315 Ago1-005 protein_coding Mus_musculus 0 1033
ENSDART00000091813 ago3b-001 protein_coding Danio_rerio 0 1033
ENSMUST00000069097 Ago3-001 protein_coding Mus_musculus 0 878

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