C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Raf-1 proto-oncogene, serine/threonine kinase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000251849 RAF1-001 ENSG00000132155 9606 - 3:12583601-12664226 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000251849
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000251849 15.085±0.00 3.836±0.00 5.098±0.00 9.350±2.50 6.234±0.00 19.543±17.84 9.550±7.47 7.612±2.57 10.466±4.08 31.238±15.89 15.878±11.92 13.583±5.51 13.454±3.51

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004KF CIL_0004KF_0001 CGP 3:12514934-12583713
CIL_0005SJ CIL_0005SJ_0001 CGP 3:12557014-12664226
CIL_0005SC CIL_0005SC_0001 CGP 3:12583601-12769457

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000165 TAS MAPK cascade
GO:0000186 TAS activation of MAPKK activity
GO:0001666 IEA response to hypoxia
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004709 IEA MAP kinase kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005057 IEA receptor signaling protein activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 ISS cytoplasm
GO:0005741 TAS mitochondrial outer membrane
GO:0005794 IPI Golgi apparatus
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0006915 TAS apoptotic process
GO:0007165 TAS:IEA signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007190 NAS activation of adenylate cyclase activity
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007265 TAS Ras protein signal transduction
GO:0007268 TAS synaptic transmission
GO:0007411 TAS axon guidance
GO:0007507 IEA heart development
GO:0007596 TAS blood coagulation
GO:0008283 TAS cell proliferation
GO:0008285 IDA negative regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017016 IEA Ras GTPase binding
GO:0030154 IEA cell differentiation
GO:0030168 TAS platelet activation
GO:0031143 IEA pseudopodium
GO:0031333 IDA negative regulation of protein complex assembly
GO:0031434 IEA mitogen-activated protein kinase kinase binding
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0034220 TAS ion transmembrane transport
GO:0035019 IEA somatic stem cell maintenance
GO:0035023 TAS regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042060 TAS wound healing
GO:0042802 IPI identical protein binding
GO:0042981 TAS regulation of apoptotic process
GO:0043066 IDA negative regulation of apoptotic process
GO:0043154 TAS negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 TAS innate immune response
GO:0045104 IEA intermediate filament cytoskeleton organization
GO:0045595 TAS regulation of cell differentiation
GO:0046872 IEA metal ion binding
GO:0046982 IEA protein heterodimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0055085 TAS transmembrane transport
GO:0071550 IEA death-inducing signaling complex assembly
GO:1902042 IEA negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000145 TAS regulation of cell motility

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000000451 Raf1-001 protein_coding Mus_musculus 0 2758
ENSMUST00000112949 Raf1-003 protein_coding Mus_musculus 0 2736
ENSMUST00000127503 Raf1-002 retained_intron Mus_musculus 0 1218
ENSMUST00000130528 Raf1-006 retained_intron Mus_musculus 0 833
ENSMUST00000124553 Raf1-005 processed_transcript Mus_musculus 0 747
ENSMUST00000147979 Raf1-004 protein_coding Mus_musculus 0 370
ENSMUST00000000449 Mkrn2-201 protein_coding Mus_musculus 0.000000008 68

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