C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: mitogen-activated protein kinase kinase 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000262948 MAP2K2-001 ENSG00000126934 9606 - 19:4090321-4124129 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262948
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262948 8.999±0.00 23.253±0.00 4.803±0.00 13.660±9.57 12.515±6.73 19.304±10.84 19.723±16.40 15.571±4.80 15.651±12.17 17.390±14.44 46.688±15.44 36.620±22.25 55.045±24.36 89.488±41.70

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005QS CIL_0005QS_0002 CGP 19:4044364-4124129

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000165 TAS MAPK cascade
GO:0000186 TAS activation of MAPKK activity
GO:0000187 TAS activation of MAPK activity
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004674 IEA:TAS protein serine/threonine kinase activity
GO:0004708 IDA MAP kinase kinase activity
GO:0004712 TAS protein serine/threonine/tyrosine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005576 NAS extracellular region
GO:0005634 TAS nucleus
GO:0005737 IDA cytoplasm
GO:0005739 TAS mitochondrion
GO:0005769 TAS early endosome
GO:0005770 TAS late endosome
GO:0005778 IDA peroxisomal membrane
GO:0005783 IDA endoplasmic reticulum
GO:0005794 TAS Golgi apparatus
GO:0005829 TAS cytosol
GO:0005874 IDA microtubule
GO:0005911 IDA cell-cell junction
GO:0005925 TAS focal adhesion
GO:0005938 IEA cell cortex
GO:0006468 IEA protein phosphorylation
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007265 TAS Ras protein signal transduction
GO:0007411 TAS axon guidance
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009898 IDA cytoplasmic side of plasma membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030165 IDA PDZ domain binding
GO:0032872 TAS regulation of stress-activated MAPK cascade
GO:0032947 IEA protein complex scaffold
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0036289 IDA peptidyl-serine autophosphorylation
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0043539 IDA protein serine/threonine kinase activator activity
GO:0045087 TAS innate immune response
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048471 IDA perinuclear region of cytoplasm
GO:0051403 TAS stress-activated MAPK cascade
GO:0070371 TAS ERK1 and ERK2 cascade
GO:0071902 IDA positive regulation of protein serine/threonine kinase activity
GO:0090170 TAS regulation of Golgi inheritance
GO:0097110 IPI scaffold protein binding
GO:2000147 IEA positive regulation of cell motility
GO:2000641 TAS regulation of early endosome to late endosome transport

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000105331 Map2k2-002 protein_coding Mus_musculus 0 1434
ENSMUST00000143517 Map2k2-001 protein_coding Mus_musculus 0 1421
ENSMUST00000048223 Map2k2-003 nonsense_mediated_decay Mus_musculus 0 756
ENSMUST00000005066 Map2k1-001 protein_coding Mus_musculus 0 616
ENSMUST00000123888 Map2k2-005 retained_intron Mus_musculus 9.80909e-45 185

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