C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: achaete-scute family bHLH transcription factor 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000266744 ASCL1-001 ENSG00000139352 9606 + 12:102957686-102960516 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartLungMuscleOvaryPlacentaTestisENST00000266744
Transcript ID Adipose Adrenal Brain Breast Colon Heart Lung Muscle Ovary Placenta Testis
ENST00000266744 0.021±0.00 0.047±0.00 4.520±1.32 0.013±0.00 0.053±0.00 0.013±0.00 0.028±0.00 0.055±0.00 0.123±0.02 0.047±0.02 0.453±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008O5 CIL_0008O5_0001 VISTA 12:102651485-103252902
CIL_0008WZ CIL_0008WZ_0001 VISTA 12:102677571-103278832
CIL_0008TA CIL_0008TA_0001 VISTA 12:102711332-103315018
CIL_0009AL CIL_0009AL_0001 VISTA 12:102712107-103314512
CIL_0008NV CIL_0008NV_0001 VISTA 12:102712346-103314376
CIL_0008OX CIL_0008OX_0001 VISTA 12:102790564-103391741
CIL_0007I3 CIL_0007I3_0002 CGP 12:102836885-102960516
CIL_00083Z CIL_00083Z_0001 VISTA 12:102877204-103479620
CIL_0007WM CIL_0007WM_0001 VISTA 12:102920166-103521542

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000989 ISS transcription factor binding transcription factor activity
GO:0001764 IEA neuron migration
GO:0003358 ISS noradrenergic neuron development
GO:0003359 IMP noradrenergic neuron fate commitment
GO:0003677 ISS DNA binding
GO:0003682 IEA chromatin binding
GO:0003690 IEA double-stranded DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0006351 IEA transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0007219 IDA Notch signaling pathway
GO:0007346 IEA regulation of mitotic cell cycle
GO:0007389 IEA pattern specification process
GO:0007399 IEA nervous system development
GO:0007400 IEA neuroblast fate determination
GO:0007405 IEA neuroblast proliferation
GO:0008593 IEA regulation of Notch signaling pathway
GO:0010001 IEA glial cell differentiation
GO:0010226 IEA response to lithium ion
GO:0010468 ISS regulation of gene expression
GO:0014003 IEA oligodendrocyte development
GO:0021527 IEA spinal cord association neuron differentiation
GO:0021529 IEA spinal cord oligodendrocyte cell differentiation
GO:0021530 IEA spinal cord oligodendrocyte cell fate specification
GO:0021750 IEA vestibular nucleus development
GO:0021779 IEA oligodendrocyte cell fate commitment
GO:0021879 IEA forebrain neuron differentiation
GO:0021892 IEP cerebral cortex GABAergic interneuron differentiation
GO:0021902 IEA commitment of neuronal cell to specific neuron type in forebrain
GO:0021954 IEA central nervous system neuron development
GO:0021987 IEA cerebral cortex development
GO:0022008 IDA neurogenesis
GO:0030154 IEA cell differentiation
GO:0030182 IEA neuron differentiation
GO:0030856 IEA regulation of epithelial cell differentiation
GO:0032526 IEP response to retinoic acid
GO:0042127 IEA regulation of cell proliferation
GO:0042803 IEA protein homodimerization activity
GO:0043025 IEA neuronal cell body
GO:0043066 IMP negative regulation of apoptotic process
GO:0043425 IPI bHLH transcription factor binding
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0043565 IEA sequence-specific DNA binding
GO:0045665 IDA negative regulation of neuron differentiation
GO:0045666 ISS positive regulation of neuron differentiation
GO:0045747 IEA positive regulation of Notch signaling pathway
GO:0045787 IEA positive regulation of cell cycle
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046983 IEA protein dimerization activity
GO:0048469 IEA cell maturation
GO:0048485 NAS sympathetic nervous system development
GO:0048663 IEA neuron fate commitment
GO:0048665 IEA neuron fate specification
GO:0048666 IEA neuron development
GO:0048699 IEA generation of neurons
GO:0048709 IEA oligodendrocyte differentiation
GO:0050767 IEA regulation of neurogenesis
GO:0050769 IEA positive regulation of neurogenesis
GO:0050883 IEA musculoskeletal movement, spinal reflex action
GO:0051593 IEA response to folic acid
GO:0060163 IEA subpallium neuron fate commitment
GO:0060165 IEA regulation of timing of subpallium neuron differentiation
GO:0060166 IEA olfactory pit development
GO:0060487 NAS lung epithelial cell differentiation
GO:0060579 ISS ventral spinal cord interneuron fate commitment
GO:0061100 IEA lung neuroendocrine cell differentiation
GO:0061102 IEA stomach neuroendocrine cell differentiation
GO:0061103 IEA carotid body glomus cell differentiation
GO:0061104 IEA adrenal chromaffin cell differentiation
GO:0061549 ISS sympathetic ganglion development
GO:0070849 IEA response to epidermal growth factor
GO:0070888 IDA E-box binding
GO:0071259 IEA cellular response to magnetism
GO:2000179 IEA positive regulation of neural precursor cell proliferation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000020243 Ascl1-001 protein_coding Mus_musculus 0 929

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