C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: paired-like homeodomain 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000306732 PITX2-005 ENSG00000164093 9606 - 4:110617423-110623103 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BreastColonHeartKidneyLiverMusclePlacentaTestisENST00000306732
Transcript ID Breast Colon Heart Kidney Liver Muscle Placenta Testis
ENST00000306732 0.657±0.00 0.175±0.00 0.023±0.00 0.414±0.00 1.466±0.00 7.504±6.07 12.235±8.56 1.096±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000917 CIL_000917_0001 VISTA 4:110309018-110909617
CIL_000912 CIL_000912_0001 VISTA 4:110357117-110957671
CIL_0007ZJ CIL_0007ZJ_0001 VISTA 4:110448103-111050012
CIL_0007RD CIL_0007RD_0001 VISTA 4:110613299-111214576

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000976 IDA transcription regulatory region sequence-specific DNA binding
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 IEA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085 IPI RNA polymerase II transcription factor binding
GO:0001102 IPI RNA polymerase II activating transcription factor binding
GO:0001105 IDA RNA polymerase II transcription coactivator activity
GO:0001191 IDA RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0001569 IEA patterning of blood vessels
GO:0001570 IEA vasculogenesis
GO:0001701 IEA in utero embryonic development
GO:0001764 IEA neuron migration
GO:0002074 IEA extraocular skeletal muscle development
GO:0003171 IEA atrioventricular valve development
GO:0003253 ISS cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0003350 IEA pulmonary myocardium development
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IDA transcription factor complex
GO:0005737 IEA cytoplasm
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007368 ISS determination of left/right symmetry
GO:0007420 IEA brain development
GO:0007507 IEA heart development
GO:0007519 IEA skeletal muscle tissue development
GO:0007520 IEA myoblast fusion
GO:0008134 IPI transcription factor binding
GO:0008584 IEA male gonad development
GO:0008585 IEA female gonad development
GO:0009653 IEA anatomical structure morphogenesis
GO:0009725 IEA response to hormone
GO:0009887 IEA organ morphogenesis
GO:0016055 IEA Wnt signaling pathway
GO:0021763 IEA subthalamic nucleus development
GO:0021855 IEA hypothalamus cell migration
GO:0021983 IEA pituitary gland development
GO:0030182 IEA neuron differentiation
GO:0030324 IEA lung development
GO:0030334 IEA regulation of cell migration
GO:0031076 IEA embryonic camera-type eye development
GO:0031490 IEA chromatin DNA binding
GO:0033189 IEA response to vitamin A
GO:0035116 IEA embryonic hindlimb morphogenesis
GO:0035315 IC hair cell differentiation
GO:0035886 IEA vascular smooth muscle cell differentiation
GO:0035993 IMP deltoid tuberosity development
GO:0042127 IEA regulation of cell proliferation
GO:0042475 IEA odontogenesis of dentin-containing tooth
GO:0042476 IMP odontogenesis
GO:0042803 IPI protein homodimerization activity
GO:0043010 IMP camera-type eye development
GO:0043021 IC ribonucleoprotein complex binding
GO:0043388 IEA positive regulation of DNA binding
GO:0043565 IEA sequence-specific DNA binding
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048536 ISS spleen development
GO:0048557 IEA embryonic digestive tract morphogenesis
GO:0048738 IEA cardiac muscle tissue development
GO:0051219 IPI phosphoprotein binding
GO:0055007 IEA cardiac muscle cell differentiation
GO:0055009 IEA atrial cardiac muscle tissue morphogenesis
GO:0055015 IEA ventricular cardiac muscle cell development
GO:0055123 IEA digestive system development
GO:0060126 TAS somatotropin secreting cell differentiation
GO:0060127 TAS prolactin secreting cell differentiation
GO:0060412 IEA ventricular septum morphogenesis
GO:0060460 IEA left lung morphogenesis
GO:0060577 IEA pulmonary vein morphogenesis
GO:0060578 IEA superior vena cava morphogenesis
GO:0061031 IEA endodermal digestive tract morphogenesis
GO:0061072 IMP iris morphogenesis
GO:0061325 ISS cell proliferation involved in outflow tract morphogenesis
GO:0070986 ISS left/right axis specification
GO:2000288 IEA positive regulation of myoblast proliferation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000042587 Pitx2-003 protein_coding Mus_musculus 0 2490
ENSMUST00000106382 Pitx2-001 protein_coding Mus_musculus 0 1973
ENSMUST00000174661 Pitx2-002 protein_coding Mus_musculus 0 1969
ENSMUST00000029657 Pitx2-005 protein_coding Mus_musculus 0 1666
ENSMUST00000172645 Pitx2-006 protein_coding Mus_musculus 0 1109
ENSMUST00000174623 Pitx2-004 protein_coding Mus_musculus 0 597
ENSMUST00000187145 Pitx2-007 retained_intron Mus_musculus 0 593

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