C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: synuclein, alpha (non A4 component of amyloid precursor)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000336904 SNCA-003 ENSG00000145335 9606 - 4:89724099-89838315 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainColonLiverLungOvaryPlacentaENST00000336904
Transcript ID Brain Colon Liver Lung Ovary Placenta
ENST00000336904 7.566±0.00 0.230±0.00 0.521±0.00 0.624±0.00 0.537±0.00 1.035±0.07

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00083N CIL_00083N_0001 VISTA 4:89695882-90299902
CIL_0000KO CIL_0000KO_0001 CGP 4:89724099-89954629

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 TAS negative regulation of transcription from RNA polymerase II promoter
GO:0000287 IDA magnesium ion binding
GO:0001774 TAS microglial cell activation
GO:0001921 IDA positive regulation of receptor recycling
GO:0001933 IEA negative regulation of protein phosphorylation
GO:0001956 IEA positive regulation of neurotransmitter secretion
GO:0001963 IEA synaptic transmission, dopaminergic
GO:0005507 IDA copper ion binding
GO:0005509 IDA calcium ion binding
GO:0005515 IPI protein binding
GO:0005543 IDA phospholipid binding
GO:0005576 TAS extracellular region
GO:0005634 IDA nucleus
GO:0005640 IEA nuclear outer membrane
GO:0005737 IDA cytoplasm
GO:0005739 TAS mitochondrion
GO:0005747 TAS mitochondrial respiratory chain complex I
GO:0005764 TAS lysosome
GO:0005791 IEA rough endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005829 IDA cytosol
GO:0005840 IEA ribosome
GO:0005856 IEA cytoskeleton
GO:0005886 IDA plasma membrane
GO:0005938 IDA cell cortex
GO:0006631 IEA fatty acid metabolic process
GO:0006638 IEA neutral lipid metabolic process
GO:0006644 IEA phospholipid metabolic process
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007006 IEA mitochondrial membrane organization
GO:0007268 IEA synaptic transmission
GO:0007568 IEA aging
GO:0008017 IEA microtubule binding
GO:0008021 IEA synaptic vesicle
GO:0008198 IDA ferrous iron binding
GO:0008270 IDA zinc ion binding
GO:0008344 IEA adult locomotory behavior
GO:0010040 IDA response to iron(II) ion
GO:0010517 IDA regulation of phospholipase activity
GO:0010642 IDA negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0014048 IEA regulation of glutamate secretion
GO:0014059 TAS regulation of dopamine secretion
GO:0015629 IDA actin cytoskeleton
GO:0016234 IDA inclusion body
GO:0016491 IDA oxidoreductase activity
GO:0019894 IPI kinesin binding
GO:0019899 IEA enzyme binding
GO:0019904 IEA protein domain specific binding
GO:0030054 IEA cell junction
GO:0030424 IDA axon
GO:0030426 IDA growth cone
GO:0030544 IPI Hsp70 protein binding
GO:0030659 IEA cytoplasmic vesicle membrane
GO:0031092 IDA platelet alpha granule membrane
GO:0031115 IDA negative regulation of microtubule polymerization
GO:0031623 IDA receptor internalization
GO:0031648 IDA protein destabilization
GO:0032026 IDA response to magnesium ion
GO:0032410 IDA negative regulation of transporter activity
GO:0032496 IDA response to lipopolysaccharide
GO:0032769 IDA negative regulation of monooxygenase activity
GO:0033138 ISS positive regulation of peptidyl-serine phosphorylation
GO:0034341 IDA response to interferon-gamma
GO:0034599 IC cellular response to oxidative stress
GO:0035067 IDA negative regulation of histone acetylation
GO:0036465 TAS synaptic vesicle recycling
GO:0040012 IEA regulation of locomotion
GO:0042220 IEA response to cocaine
GO:0042393 IDA histone binding
GO:0042416 TAS dopamine biosynthetic process
GO:0042417 IEA dopamine metabolic process
GO:0042493 IEA response to drug
GO:0042775 IEA mitochondrial ATP synthesis coupled electron transport
GO:0042802 IPI identical protein binding
GO:0043014 IPI alpha-tubulin binding
GO:0043027 IDA cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043030 IEA regulation of macrophage activation
GO:0043065 TAS positive regulation of apoptotic process
GO:0043066 IMP negative regulation of apoptotic process
GO:0043154 IMP negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043195 IEA terminal bouton
GO:0043205 IDA fibril
GO:0043206 TAS extracellular fibril organization
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043274 IEA phospholipase binding
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043679 IEA axon terminus
GO:0044212 TAS transcription regulatory region DNA binding
GO:0044344 IEA cellular response to fibroblast growth factor stimulus
GO:0045202 IEA synapse
GO:0045502 IPI dynein binding
GO:0045807 IDA positive regulation of endocytosis
GO:0045920 IMP negative regulation of exocytosis
GO:0045963 IEA negative regulation of dopamine metabolic process
GO:0046928 IEA regulation of neurotransmitter secretion
GO:0047485 IEA protein N-terminus binding
GO:0048148 IEA behavioral response to cocaine
GO:0048156 IDA tau protein binding
GO:0048168 IEA regulation of neuronal synaptic plasticity
GO:0048169 IEA regulation of long-term neuronal synaptic plasticity
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048487 IEA beta-tubulin binding
GO:0048488 ISS synaptic vesicle endocytosis
GO:0048489 IEA synaptic vesicle transport
GO:0050544 IEA arachidonic acid binding
GO:0050806 IEA positive regulation of synaptic transmission
GO:0050808 IEA synapse organization
GO:0050812 IEA regulation of acyl-CoA biosynthetic process
GO:0051219 IDA phosphoprotein binding
GO:0051281 IDA positive regulation of release of sequestered calcium ion into cytosol
GO:0051583 TAS dopamine uptake involved in synaptic transmission
GO:0051585 IDA negative regulation of dopamine uptake involved in synaptic transmission
GO:0051612 IDA negative regulation of serotonin uptake
GO:0051622 IDA negative regulation of norepinephrine uptake
GO:0055114 IDA oxidation-reduction process
GO:0060079 IEA regulation of excitatory postsynaptic membrane potential
GO:0060291 IEA long-term synaptic potentiation
GO:0060732 IDA positive regulation of inositol phosphate biosynthetic process
GO:0061024 IEA membrane organization
GO:0070495 IDA negative regulation of thrombin receptor signaling pathway
GO:0070555 IDA response to interleukin-1
GO:0071280 IDA cellular response to copper ion
GO:0071872 TAS cellular response to epinephrine stimulus
GO:0071902 IDA positive regulation of protein serine/threonine kinase activity
GO:1901214 IGI regulation of neuron death
GO:1902957 TAS negative regulation of mitochondrial electron transport, NADH to ubiquinone
GO:1903284 IDA positive regulation of glutathione peroxidase activity
GO:1903285 IDA positive regulation of hydrogen peroxide catabolic process
GO:1903426 TAS regulation of reactive oxygen species biosynthetic process
GO:2000377 IEA regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000114268 Snca-201 protein_coding Mus_musculus 0 1007
ENSMUST00000163779 Snca-202 protein_coding Mus_musculus 0 1007

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