C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: orthodenticle homeobox 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000339475 OTX2-001 ENSG00000165588 9606 - 14:56799905-56810469 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBreastOvaryPlacentaTestisENST00000339475
Transcript ID Adipose Breast Ovary Placenta Testis
ENST00000339475 0.011±0.00 0.011±0.00 0.009±0.00 0.015±0.00 0.184±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000602 CIL_000602_0002 CGP 14:56488354-56810479
CIL_0007P7 CIL_0007P7_0001 UCNEbase 14:56513836-57292417
CIL_00083W CIL_00083W_0001 VISTA 14:56553946-57157601
CIL_000869 CIL_000869_0001 VISTA 14:56652290-57254727
CIL_0009BX CIL_0009BX_0001 VISTA 14:56664169-57265628
CIL_000822 CIL_000822_0001 VISTA 14:56707426-57311372
CIL_0005ZZ CIL_0005ZZ_0002 CGP 14:56799905-57269008

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001708 IEA cell fate specification
GO:0003677 IEA DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006461 IDA protein complex assembly
GO:0007275 IEA multicellular organismal development
GO:0007411 IDA axon guidance
GO:0007417 IEA central nervous system development
GO:0007492 IEA endoderm development
GO:0008190 TAS eukaryotic initiation factor 4E binding
GO:0008589 TAS regulation of smoothened signaling pathway
GO:0009887 IEA organ morphogenesis
GO:0009952 IEA anterior/posterior pattern specification
GO:0009953 IEA dorsal/ventral pattern formation
GO:0022037 IEA metencephalon development
GO:0030154 IEA cell differentiation
GO:0030182 IEA neuron differentiation
GO:0030426 IDA growth cone
GO:0030900 TAS forebrain development
GO:0030901 TAS midbrain development
GO:0032525 IEA somite rostral/caudal axis specification
GO:0040019 ISS positive regulation of embryonic development
GO:0040036 TAS regulation of fibroblast growth factor receptor signaling pathway
GO:0042472 IEA inner ear morphogenesis
GO:0042706 IEA eye photoreceptor cell fate commitment
GO:0043234 IDA protein complex
GO:0043565 IEA sequence-specific DNA binding
GO:0045165 IEA cell fate commitment
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IEA protein heterodimerization activity
GO:0048663 IEA neuron fate commitment
GO:0048664 IEA neuron fate determination
GO:0048852 IEA diencephalon morphogenesis
GO:0048856 IEA anatomical structure development
GO:0090009 ISS primitive streak formation
GO:2000543 ISS positive regulation of gastrulation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000118578 Otx2-001 protein_coding Mus_musculus 0 2549
ENSMUST00000119070 Otx2-002 protein_coding Mus_musculus 0 2302
ENSMUST00000122009 Otx2-003 protein_coding Mus_musculus 0 2032
ENSMUST00000152018 Otx2-004 protein_coding Mus_musculus 0 1094
ENSMUST00000135279 Otx2-005 protein_coding Mus_musculus 0 835
ENSMUST00000144465 Otx2-007 protein_coding Mus_musculus 0 599
ENSMUST00000133479 Otx2-006 protein_coding Mus_musculus 0 339
ENSMUST00000119739 Otx2-008 protein_coding Mus_musculus 0 292

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