C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: caveolin 1, caveolae protein, 22kDa
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000341049 CAV1-001 ENSG00000105974 9606 + 7:116524785-116561176 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000341049
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000341049 19.334±0.00 7.597±0.00 1.433±0.00 0.613±0.35 34.515±19.28 18.604±5.71 18.635±0.78 1.646±0.26 39.401±0.00 25.727±0.16 3.380±0.89 7.333±3.74 38.642±2.35 7.215±3.55

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007SP CIL_0007SP_0001 VISTA 7:116053609-116657055
CIL_00063M CIL_00063M_0002 CGP 7:116287380-116561184
CIL_00063L CIL_00063L_0002 CGP 7:116524785-116798386

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000139 IEA:IDA Golgi membrane
GO:0000165 IEA MAPK cascade
GO:0000188 ISS inactivation of MAPK activity
GO:0001525 IEA angiogenesis
GO:0001570 ISS vasculogenesis
GO:0001666 ISS response to hypoxia
GO:0001937 ISS negative regulation of endothelial cell proliferation
GO:0001960 IEA negative regulation of cytokine-mediated signaling pathway
GO:0002026 IEA regulation of the force of heart contraction
GO:0002080 IEA acrosomal membrane
GO:0002931 IEA response to ischemia
GO:0003057 IEA regulation of the force of heart contraction by chemical signal
GO:0005102 IPI receptor binding
GO:0005113 NAS patched binding
GO:0005198 IDA structural molecule activity
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005768 IDA endosome
GO:0005783 IDA endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005811 TAS lipid particle
GO:0005886 IDA plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0005901 IEA:IDA caveola
GO:0005925 IDA focal adhesion
GO:0005929 IEA cilium
GO:0005938 IEA cell cortex
GO:0006641 ISS triglyceride metabolic process
GO:0006816 ISS calcium ion transport
GO:0006874 ISS cellular calcium ion homeostasis
GO:0006940 ISS regulation of smooth muscle contraction
GO:0007519 ISS skeletal muscle tissue development
GO:0007595 IEA lactation
GO:0007596 TAS blood coagulation
GO:0008104 ISS protein localization
GO:0008285 IEA negative regulation of cell proliferation
GO:0009267 IEP cellular response to starvation
GO:0009968 IEA negative regulation of signal transduction
GO:0010524 ISS positive regulation of calcium ion transport into cytosol
GO:0010952 IEA positive regulation of peptidase activity
GO:0015485 TAS cholesterol binding
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016032 IEA viral process
GO:0016050 IDA vesicle organization
GO:0016323 IDA basolateral plasma membrane
GO:0016324 IDA apical plasma membrane
GO:0016504 ISS peptidase activator activity
GO:0019217 ISS regulation of fatty acid metabolic process
GO:0019899 IPI enzyme binding
GO:0019915 ISS lipid storage
GO:0030193 IMP regulation of blood coagulation
GO:0030301 TAS cholesterol transport
GO:0030514 IDA negative regulation of BMP signaling pathway
GO:0030666 TAS endocytic vesicle membrane
GO:0030857 ISS negative regulation of epithelial cell differentiation
GO:0030879 ISS mammary gland development
GO:0031295 IDA T cell costimulation
GO:0031397 IMP negative regulation of protein ubiquitination
GO:0031410 IDA cytoplasmic vesicle
GO:0032091 IDA negative regulation of protein binding
GO:0032507 ISS maintenance of protein location in cell
GO:0032570 IDA response to progesterone
GO:0032947 TAS protein complex scaffold
GO:0033137 IDA negative regulation of peptidyl-serine phosphorylation
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0033484 ISS nitric oxide homeostasis
GO:0042310 IEA vasoconstriction
GO:0042524 IEA negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0042632 ISS cholesterol homeostasis
GO:0043234 IDA protein complex
GO:0043407 IEA negative regulation of MAP kinase activity
GO:0043409 ISS negative regulation of MAPK cascade
GO:0043627 IDA response to estrogen
GO:0044281 TAS small molecule metabolic process
GO:0045019 ISS negative regulation of nitric oxide biosynthetic process
GO:0045121 IDA membrane raft
GO:0045907 ISS positive regulation of vasoconstriction
GO:0046209 TAS nitric oxide metabolic process
GO:0046426 ISS negative regulation of JAK-STAT cascade
GO:0048471 ISS perinuclear region of cytoplasm
GO:0048550 IMP negative regulation of pinocytosis
GO:0048554 ISS positive regulation of metalloenzyme activity
GO:0050900 TAS leukocyte migration
GO:0050998 IPI nitric-oxide synthase binding
GO:0050999 TAS regulation of nitric-oxide synthase activity
GO:0051001 IEA negative regulation of nitric-oxide synthase activity
GO:0051259 IEA protein oligomerization
GO:0051260 ISS protein homooligomerization
GO:0051480 IDA cytosolic calcium ion homeostasis
GO:0051592 ISS response to calcium ion
GO:0051899 ISS membrane depolarization
GO:0052547 ISS regulation of peptidase activity
GO:0055074 ISS calcium ion homeostasis
GO:0060056 ISS mammary gland involution
GO:0070836 IMP caveola assembly
GO:0071455 IMP cellular response to hyperoxia
GO:0072584 IDA caveolin-mediated endocytosis
GO:0090090 ISS negative regulation of canonical Wnt signaling pathway
GO:0090263 IMP positive regulation of canonical Wnt signaling pathway
GO:0097190 IMP apoptotic signaling pathway
GO:2000286 IMP receptor internalization involved in canonical Wnt signaling pathway
GO:2000811 IMP negative regulation of anoikis
GO:2001238 IMP positive regulation of extrinsic apoptotic signaling pathway
GO:2001244 IMP positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000007799 Cav1-001 protein_coding Mus_musculus 0 937
ENSMUST00000115456 Cav1-008 protein_coding Mus_musculus 0 898
ENSMUST00000115453 Cav1-002 protein_coding Mus_musculus 0 760
ENSMUST00000115454 Cav1-007 protein_coding Mus_musculus 0 732
ENSMUST00000177234 Cav1-010 nonsense_mediated_decay Mus_musculus 0 656
ENSMUST00000115455 Cav1-009 protein_coding Mus_musculus 0 472
ENSMUST00000130505 Cav1-003 protein_coding Mus_musculus 0 340
ENSMUST00000123439 Cav1-006 protein_coding Mus_musculus 0 326
ENSMUST00000150901 Cav1-005 protein_coding Mus_musculus 0 324
ENSMUST00000133065 Cav1-004 processed_transcript Mus_musculus 0 254

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