C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: enhancer of zeste 2 polycomb repressive complex 2 subunit
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000350995 EZH2-010 ENSG00000106462 9606 - 7:148807385-148884248 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainBreastColonLungMuscleOvaryPlacentaENST00000350995
Transcript ID Brain Breast Colon Lung Muscle Ovary Placenta
ENST00000350995 0.236±0.00 0.232±0.00 0.051±0.00 0.411±0.00 0.518±0.00 2.380±0.00 0.877±0.12

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004XU CIL_0004XU_0001 CGP 7:148697914-148884321
CIL_0004XT CIL_0004XT_0001 CGP 7:148807383-149028641

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0001047 ISS core promoter binding
GO:0003677 TAS:IEA DNA binding
GO:0003682 IDA:IEA chromatin binding
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0006325 TAS chromatin organization
GO:0006351 IEA transcription, DNA-templated
GO:0006355 TAS regulation of transcription, DNA-templated
GO:0010718 IDA positive regulation of epithelial to mesenchymal transition
GO:0018024 IEA histone-lysine N-methyltransferase activity
GO:0031490 IDA chromatin DNA binding
GO:0032320 IDA positive regulation of Ras GTPase activity
GO:0035098 IDA ESC/E(Z) complex
GO:0042054 IDA histone methyltransferase activity
GO:0042752 IMP regulation of circadian rhythm
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0045814 IDA negative regulation of gene expression, epigenetic
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0046976 TAS histone methyltransferase activity (H3-K27 specific)
GO:0048387 IMP negative regulation of retinoic acid receptor signaling pathway
GO:0070734 IDA histone H3-K27 methylation
GO:0071902 IDA positive regulation of protein serine/threonine kinase activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000114616 Ezh2-004 protein_coding Mus_musculus 0 3546
ENSMUST00000081721 Ezh2-001 protein_coding Mus_musculus 0 3070
ENSMUST00000114618 Ezh2-003 protein_coding Mus_musculus 0 3011
ENSMUST00000092648 Ezh2-010 protein_coding Mus_musculus 0 1611
ENSMUST00000165492 Ezh2-009 retained_intron Mus_musculus 0 723
ENSMUST00000167278 Ezh2-007 nonsense_mediated_decay Mus_musculus 0 643
ENSMUST00000169889 Ezh2-006 nonsense_mediated_decay Mus_musculus 0 599
ENSMUST00000133043 Ezh2-002 protein_coding Mus_musculus 0 510
ENSMUST00000170327 Ezh2-005 retained_intron Mus_musculus 0 416
ENSMUST00000171614 Ezh2-012 retained_intron Mus_musculus 0 346
ENSMUST00000170311 Ezh2-011 retained_intron Mus_musculus 0 302
ENSMUST00000164006 Ezh2-008 nonsense_mediated_decay Mus_musculus 4.00001e-40 171

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