C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: FYN proto-oncogene, Src family tyrosine kinase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000354650 FYN-001 ENSG00000010810 9606 - 6:111660332-111873452 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastHeartKidneyOvaryPlacentaTestisENST00000354650
Transcript ID Adrenal Brain Breast Heart Kidney Ovary Placenta Testis
ENST00000354650 3.844±0.00 5.678±1.93 2.393±0.69 0.805±0.28 1.664±0.00 3.577±0.00 1.450±0.00 1.982±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000954 CIL_000954_0001 VISTA 6:111250485-111855465

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001664 IEA G-protein coupled receptor binding
GO:0001764 IEA neuron migration
GO:0001948 IPI glycoprotein binding
GO:0004672 IEA protein kinase activity
GO:0004713 TAS:IEA protein tyrosine kinase activity
GO:0004715 NAS non-membrane spanning protein tyrosine kinase activity
GO:0005102 IEA receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005739 IEA mitochondrion
GO:0005768 IDA endosome
GO:0005829 TAS cytosol
GO:0005884 IEA actin filament
GO:0005886 IDA plasma membrane
GO:0006468 NAS:IEA protein phosphorylation
GO:0006816 NAS calcium ion transport
GO:0007166 IEA cell surface receptor signaling pathway
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0007612 TAS learning
GO:0007631 TAS feeding behavior
GO:0008360 IEA regulation of cell shape
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0010629 IEA negative regulation of gene expression
GO:0010976 IEA positive regulation of neuron projection development
GO:0014068 IEA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 IEA postsynaptic density
GO:0015631 IEA tubulin binding
GO:0016020 IEA membrane
GO:0016032 TAS viral process
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030168 TAS platelet activation
GO:0030900 IEA forebrain development
GO:0031295 TAS T cell costimulation
GO:0032403 IEA protein complex binding
GO:0035556 TAS intracellular signal transduction
GO:0036120 IEA cellular response to platelet-derived growth factor stimulus
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042177 IEA negative regulation of protein catabolic process
GO:0042493 IEA response to drug
GO:0042608 IEA T cell receptor binding
GO:0042609 IEA CD4 receptor binding
GO:0042610 IEA CD8 receptor binding
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043548 IEA phosphatidylinositol 3-kinase binding
GO:0044325 IEA ion channel binding
GO:0045087 TAS innate immune response
GO:0045121 IDA membrane raft
GO:0045471 IEA response to ethanol
GO:0046777 IEA protein autophosphorylation
GO:0046872 IEA metal ion binding
GO:0046875 IPI ephrin receptor binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048813 IEA dendrite morphogenesis
GO:0050690 TAS regulation of defense response to virus by virus
GO:0050798 IEA activated T cell proliferation
GO:0050852 IDA T cell receptor signaling pathway
GO:0050900 TAS leukocyte migration
GO:0050966 IEA detection of mechanical stimulus involved in sensory perception of pain
GO:0051428 IEA peptide hormone receptor binding
GO:0070851 IPI growth factor receptor binding
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071375 IEA cellular response to peptide hormone stimulus
GO:0071944 IEA cell periphery
GO:1900182 IEA positive regulation of protein localization to nucleus
GO:2001240 IEA negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000099967 Fyn-002 protein_coding Mus_musculus 0 3892
ENSMUST00000063091 Fyn-001 protein_coding Mus_musculus 0 2272
ENSMUST00000126486 Fyn-003 protein_coding Mus_musculus 0 1604
ENSMUST00000136659 Fyn-008 protein_coding Mus_musculus 0 1598
ENSMUST00000146287 Fyn-005 protein_coding Mus_musculus 0 1480
ENSMUST00000135242 Fyn-004 protein_coding Mus_musculus 0 1480
ENSDART00000150232 fyna-001 protein_coding Danio_rerio 0 1168
ENSDART00000023320 fyna-201 protein_coding Danio_rerio 0 1153
ENSMUST00000148152 Fyn-006 protein_coding Mus_musculus 0 636
ENSDART00000046414 fyna-202 protein_coding Danio_rerio 0 551
ENSMUST00000123205 Fyn-009 processed_transcript Mus_musculus 0 374
ENSMUST00000157009 Fyn-007 protein_coding Mus_musculus 0 259

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