C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: glutamate decarboxylase 1 (brain, 67kDa)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000358196 GAD1-001 ENSG00000128683 9606 + 2:170816562-170861151 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainHeartKidneyPlacentaENST00000358196
Transcript ID Adipose Brain Heart Kidney Placenta
ENST00000358196 0.007±0.00 2.353±0.00 0.011±0.00 0.359±0.00 0.061±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003SB CIL_0003SB_0002 CGP 2:170783786-170861151
CIL_0003SC CIL_0003SC_0002 CGP 2:170813213-170967129

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004351 IDA glutamate decarboxylase activity
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005886 TAS plasma membrane
GO:0006520 IEA cellular amino acid metabolic process
GO:0006538 TAS glutamate catabolic process
GO:0006540 TAS glutamate decarboxylation to succinate
GO:0007268 TAS synaptic transmission
GO:0007269 TAS neurotransmitter secretion
GO:0008152 IEA metabolic process
GO:0009449 IEA gamma-aminobutyric acid biosynthetic process
GO:0012506 NAS vesicle membrane
GO:0016595 IEA glutamate binding
GO:0016829 IEA lyase activity
GO:0016831 IEA carboxy-lyase activity
GO:0018352 TAS protein-pyridoxal-5-phosphate linkage
GO:0019752 IEA carboxylic acid metabolic process
GO:0030170 IEA pyridoxal phosphate binding
GO:0042136 IEA neurotransmitter biosynthetic process
GO:0042493 IEA response to drug
GO:0046982 IEA protein heterodimerization activity
GO:0047485 IEA protein N-terminus binding
GO:0061202 TAS clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000094934 Gad1-001 protein_coding Mus_musculus 0 3421
ENSMUST00000140478 Gad1-006 processed_transcript Mus_musculus 0 3125
ENSMUST00000167243 Gad1-ps-201 protein_coding Mus_musculus 0 2272
ENSMUST00000130604 Gad1-002 nonsense_mediated_decay Mus_musculus 0 1042
ENSMUST00000123330 Gad1-008 protein_coding Mus_musculus 0 1013
ENSMUST00000148210 Gad1-003 protein_coding Mus_musculus 0 881
ENSMUST00000130998 Gad1-004 protein_coding Mus_musculus 0 850
ENSMUST00000155979 Gad1-005 retained_intron Mus_musculus 0 773

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