C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: fibroblast growth factor receptor 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000359354 FGFR2-016 ENSG00000066468 9606 - 10:121537966-121598298 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BreastENST00000359354
Transcript ID Breast
ENST00000359354 4.617±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002WI CIL_0002WI_0001 CGP 10:120851175-121598458
CIL_0007TN CIL_0007TN_0001 VISTA 10:121051688-121653399
CIL_0001BE CIL_0001BE_0001 CGP 10:121478334-121928801

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0001525 ISS angiogenesis
GO:0001657 ISS ureteric bud development
GO:0001701 ISS in utero embryonic development
GO:0002053 ISS positive regulation of mesenchymal cell proliferation
GO:0003148 ISS outflow tract septum morphogenesis
GO:0003149 ISS membranous septum morphogenesis
GO:0004713 NAS protein tyrosine kinase activity
GO:0005007 IGI fibroblast growth factor-activated receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005576 IEA extracellular region
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005886 TAS plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0005938 IDA cell cortex
GO:0006915 IEA apoptotic process
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007267 ISS cell-cell signaling
GO:0007409 ISS axonogenesis
GO:0008201 IEA heparin binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 IPI fibroblast growth factor receptor signaling pathway
GO:0008589 ISS regulation of smoothened signaling pathway
GO:0009791 ISS post-embryonic development
GO:0009880 ISS embryonic pattern specification
GO:0009887 ISS organ morphogenesis
GO:0009986 IDA cell surface
GO:0010453 ISS regulation of cell fate commitment
GO:0010518 IMP positive regulation of phospholipase activity
GO:0016020 NAS membrane
GO:0016021 NAS integral component of membrane
GO:0016331 ISS morphogenesis of embryonic epithelium
GO:0017134 IPI fibroblast growth factor binding
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0021769 ISS orbitofrontal cortex development
GO:0021847 ISS ventricular zone neuroblast division
GO:0021860 ISS pyramidal neuron development
GO:0022612 ISS gland morphogenesis
GO:0030177 ISS positive regulation of Wnt signaling pathway
GO:0030282 ISS bone mineralization
GO:0030324 ISS lung development
GO:0030855 ISS epithelial cell differentiation
GO:0030901 ISS midbrain development
GO:0030916 ISS otic vesicle formation
GO:0031012 IDA extracellular matrix
GO:0031069 ISS hair follicle morphogenesis
GO:0031410 IEA cytoplasmic vesicle
GO:0032808 ISS lacrimal gland development
GO:0033688 TAS regulation of osteoblast proliferation
GO:0035264 ISS multicellular organism growth
GO:0035265 ISS organ growth
GO:0035602 ISS fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow
GO:0035603 ISS fibroblast growth factor receptor signaling pathway involved in hemopoiesis
GO:0035604 ISS fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
GO:0035607 ISS fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0040014 ISS regulation of multicellular organism growth
GO:0040036 ISS regulation of fibroblast growth factor receptor signaling pathway
GO:0042472 ISS inner ear morphogenesis
GO:0042476 ISS odontogenesis
GO:0042803 IPI protein homodimerization activity
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0043410 IMP positive regulation of MAPK cascade
GO:0045087 TAS innate immune response
GO:0045165 ISS cell fate commitment
GO:0045667 TAS regulation of osteoblast differentiation
GO:0045787 ISS positive regulation of cell cycle
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046777 IDA protein autophosphorylation
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048286 ISS lung alveolus development
GO:0048557 ISS embryonic digestive tract morphogenesis
GO:0048562 ISS embryonic organ morphogenesis
GO:0048565 ISS digestive tract development
GO:0048568 ISS embryonic organ development
GO:0048608 ISS reproductive structure development
GO:0048701 IMP embryonic cranial skeleton morphogenesis
GO:0048705 TAS skeletal system morphogenesis
GO:0048730 ISS epidermis morphogenesis
GO:0048755 ISS branching morphogenesis of a nerve
GO:0048762 ISS mesenchymal cell differentiation
GO:0050679 ISS positive regulation of epithelial cell proliferation
GO:0051150 ISS regulation of smooth muscle cell differentiation
GO:0051781 ISS positive regulation of cell division
GO:0055010 ISS ventricular cardiac muscle tissue morphogenesis
GO:0060045 ISS positive regulation of cardiac muscle cell proliferation
GO:0060076 ISS excitatory synapse
GO:0060174 ISS limb bud formation
GO:0060348 ISS bone development
GO:0060349 ISS bone morphogenesis
GO:0060442 ISS branching involved in prostate gland morphogenesis
GO:0060445 ISS branching involved in salivary gland morphogenesis
GO:0060449 ISS bud elongation involved in lung branching
GO:0060463 ISS lung lobe morphogenesis
GO:0060484 ISS lung-associated mesenchyme development
GO:0060501 ISS positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060512 ISS prostate gland morphogenesis
GO:0060523 ISS prostate epithelial cord elongation
GO:0060527 ISS prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060529 ISS squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0060595 ISS fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0060601 ISS lateral sprouting from an epithelium
GO:0060615 ISS mammary gland bud formation
GO:0060664 ISS epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060667 ISS branch elongation involved in salivary gland morphogenesis
GO:0060670 ISS branching involved in labyrinthine layer morphogenesis
GO:0060687 ISS regulation of branching involved in prostate gland morphogenesis
GO:0060688 ISS regulation of morphogenesis of a branching structure
GO:0060915 ISS mesenchymal cell differentiation involved in lung development
GO:0060916 ISS mesenchymal cell proliferation involved in lung development
GO:0070372 ISS regulation of ERK1 and ERK2 cascade
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0090263 ISS positive regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000122054 Fgfr2-004 protein_coding Mus_musculus 0 1112
ENSMUST00000153166 Fgfr2-001 nonsense_mediated_decay Mus_musculus 0 1112
ENSMUST00000117858 Fgfr2-014 protein_coding Mus_musculus 0 990
ENSMUST00000117691 Fgfr2-013 protein_coding Mus_musculus 0 990
ENSMUST00000117089 Fgfr2-012 protein_coding Mus_musculus 0 990
ENSMUST00000119260 Fgfr2-011 protein_coding Mus_musculus 0 990
ENSMUST00000120715 Fgfr2-010 protein_coding Mus_musculus 0 990
ENSMUST00000129103 Fgfr2-005 retained_intron Mus_musculus 0 763
ENSMUST00000118296 Fgfr2-018 protein_coding Mus_musculus 0 433
ENSMUST00000120141 Fgfr2-015 protein_coding Mus_musculus 0 433
ENSMUST00000117073 Fgfr2-020 protein_coding Mus_musculus 0 351
ENSMUST00000121080 Fgfr2-019 protein_coding Mus_musculus 0 351
ENSMUST00000122448 Fgfr2-017 protein_coding Mus_musculus 0 351
ENSMUST00000117357 Fgfr2-016 protein_coding Mus_musculus 0 351
ENSMUST00000120187 Fgfr2-003 protein_coding Mus_musculus 0 351
ENSMUST00000117872 Fgfr2-002 protein_coding Mus_musculus 0 351
ENSMUST00000117754 Fgfr2-009 protein_coding Mus_musculus 6.00036e-42 176
ENSMUST00000121064 Fgfr2-008 protein_coding Mus_musculus 6.00036e-42 176
ENSMUST00000127091 Fgfr2-021 nonsense_mediated_decay Mus_musculus 5e-38 163

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