C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000371941 PREX1-001 ENSG00000124126 9606 - 20:48624252-48827883 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000371941
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000371941 11.584±0.00 13.786±0.00 1.307±0.00 21.053±12.21 2.518±0.75 2.481±0.00 2.109±1.75 3.807±2.19 2.305±0.45 12.243±6.64 0.901±0.00 2.868±0.90 5.584±1.89 4.924±0.80

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00025A CIL_00025A_0001 CGP 20:47656348-48827883

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005089 TAS:IEA Rho guanyl-nucleotide exchange factor activity
GO:0005100 TAS Rho GTPase activator activity
GO:0005515 IPI:IEA protein binding
GO:0005543 IDA phospholipid binding
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0005886 TAS plasma membrane
GO:0006801 TAS superoxide metabolic process
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0019899 TAS enzyme binding
GO:0030041 TAS actin filament polymerization
GO:0030217 IEA T cell differentiation
GO:0030426 IEA growth cone
GO:0030593 IEA neutrophil chemotaxis
GO:0030833 IEA regulation of actin filament polymerization
GO:0032855 IEA positive regulation of Rac GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0042119 TAS neutrophil activation
GO:0043198 IEA dendritic shaft
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0045785 IEA positive regulation of cell adhesion
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050773 IEA regulation of dendrite development
GO:0072593 IEA reactive oxygen species metabolic process
GO:1900026 IEA positive regulation of substrate adhesion-dependent cell spreading

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000036719 Prex1-001 protein_coding Mus_musculus 0 5494
ENSMUST00000099080 Prex1-003 protein_coding Mus_musculus 0 5114
ENSMUST00000109246 Prex1-004 protein_coding Mus_musculus 0 1631
ENSDART00000078022 prex1-201 protein_coding Danio_rerio 3e-40 172
ENSDART00000138289 prex1-001 protein_coding Danio_rerio 3e-40 172

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