C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000371951 HTR2C-001 ENSG00000147246 9606 + X:114584078-114908507 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainHeartKidneyLungTestisENST00000371951
Transcript ID Brain Heart Kidney Lung Testis
ENST00000371951 0.578±0.00 0.003±0.00 0.058±0.00 0.044±0.00 0.047±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000718 CIL_000718_0001 CGP X:112774503-114910061
CIL_000719 CIL_000719_0001 CGP X:114584078-115019977

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001587 IDA Gq/11-coupled serotonin receptor activity
GO:0001662 ISS behavioral fear response
GO:0004930 IEA G-protein coupled receptor activity
GO:0004993 IDA serotonin receptor activity
GO:0005886 IDA plasma membrane
GO:0005887 IMP integral component of plasma membrane
GO:0006182 IDA cGMP biosynthetic process
GO:0006874 IDA cellular calcium ion homeostasis
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007200 IDA phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007208 ISS phospholipase C-activating serotonin receptor signaling pathway
GO:0007210 IMP serotonin receptor signaling pathway
GO:0007268 TAS synaptic transmission
GO:0007626 IEA locomotory behavior
GO:0007631 ISS feeding behavior
GO:0008144 IDA drug binding
GO:0010513 IDA positive regulation of phosphatidylinositol biosynthetic process
GO:0016021 IEA integral component of membrane
GO:0031644 ISS regulation of neurological system process
GO:0032098 ISS regulation of appetite
GO:0042493 IDA response to drug
GO:0043397 ISS regulation of corticotropin-releasing hormone secretion
GO:0051209 IMP release of sequestered calcium ion into cytosol
GO:0051378 IDA serotonin binding
GO:0051482 ISS positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0071886 IDA 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000096299 Htr2c-001 protein_coding Mus_musculus 0 1543
ENSMUST00000036303 Htr2c-002 protein_coding Mus_musculus 0 1543
ENSMUST00000156697 Htr2c-003 protein_coding Mus_musculus 0 996
ENSMUST00000112831 Htr2c-006 protein_coding Mus_musculus 0 628
ENSMUST00000131999 Htr2c-004 retained_intron Mus_musculus 0 520
ENSMUST00000149260 Htr2c-005 retained_intron Mus_musculus 0 520
ENSMUST00000134368 Htr2c-007 processed_transcript Mus_musculus 0 483

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