C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: toll-like receptor 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000394487 TLR4-002 ENSG00000136869 9606 + 9:117704332-117715775 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; HeartKidneyMuscleOvaryTestisENST00000394487
Transcript ID Heart Kidney Muscle Ovary Testis
ENST00000394487 0.670±0.00 0.664±0.00 0.431±0.00 1.193±0.00 0.060±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004FM CIL_0004FM_0001 CGP 9:116687302-117716871
CIL_0007YF CIL_0007YF_0001 VISTA 9:117463172-118064065
CIL_0004FN CIL_0004FN_0001 CGP 9:117704332-119369467

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000187 ISS activation of MAPK activity
GO:0001530 NAS lipopolysaccharide binding
GO:0001875 IDA lipopolysaccharide receptor activity
GO:0002224 TAS:IEA toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004872 TAS receptor activity
GO:0004888 NAS:IEA transmembrane signaling receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006955 TAS:IEA immune response
GO:0007165 IEA signal transduction
GO:0007249 TAS I-kappaB kinase/NF-kappaB signaling
GO:0007252 IDA I-kappaB phosphorylation
GO:0009897 IDA external side of plasma membrane
GO:0010008 TAS endosome membrane
GO:0010572 ISS positive regulation of platelet activation
GO:0016021 IEA integral component of membrane
GO:0016046 NAS detection of fungus
GO:0031663 IGI lipopolysaccharide-mediated signaling pathway
GO:0032496 IDA response to lipopolysaccharide
GO:0032497 IDA detection of lipopolysaccharide
GO:0032689 ISS negative regulation of interferon-gamma production
GO:0032700 ISS negative regulation of interleukin-17 production
GO:0032707 ISS negative regulation of interleukin-23 production
GO:0032715 ISS negative regulation of interleukin-6 production
GO:0032720 ISS negative regulation of tumor necrosis factor production
GO:0032722 IDA positive regulation of chemokine production
GO:0032727 ISS positive regulation of interferon-alpha production
GO:0032728 ISS positive regulation of interferon-beta production
GO:0032729 ISS positive regulation of interferon-gamma production
GO:0032732 ISS positive regulation of interleukin-1 production
GO:0032733 ISS positive regulation of interleukin-10 production
GO:0032735 ISS positive regulation of interleukin-12 production
GO:0032755 IDA positive regulation of interleukin-6 production
GO:0032757 IDA positive regulation of interleukin-8 production
GO:0032760 ISS positive regulation of tumor necrosis factor production
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042088 NAS T-helper 1 type immune response
GO:0042116 IMP macrophage activation
GO:0042346 IDA positive regulation of NF-kappaB import into nucleus
GO:0042535 IDA positive regulation of tumor necrosis factor biosynthetic process
GO:0042742 TAS defense response to bacterium
GO:0045084 IDA positive regulation of interleukin-12 biosynthetic process
GO:0045087 TAS innate immune response
GO:0045416 IDA positive regulation of interleukin-8 biosynthetic process
GO:0045671 NAS negative regulation of osteoclast differentiation
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046696 IDA lipopolysaccharide receptor complex
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050707 IEA regulation of cytokine secretion
GO:0050729 IC positive regulation of inflammatory response
GO:0050829 IC defense response to Gram-negative bacterium
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051770 ISS positive regulation of nitric-oxide synthase biosynthetic process
GO:0060729 ISS intestinal epithelial structure maintenance
GO:0070373 ISS negative regulation of ERK1 and ERK2 cascade
GO:0071222 ISS cellular response to lipopolysaccharide
GO:0071260 IEP cellular response to mechanical stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000048096 Tlr4-001 protein_coding Mus_musculus 0 1203

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