Warning (512): _cake_core_ cache was unable to write 'cake_dev_eng' to File cache [CORE/Cake/Cache/Cache.php, line 323]
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                ),
                E_USER_WARNING
            );
$key = 'cake_dev_eng'
$value = array(
	'LC_MESSAGES' => array()
)
$config = '_cake_core_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/persistent/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
I18n::translate() - CORE/Cake/I18n/I18n.php, line 237
__d - CORE/Cake/basics.php, line 617
Cache::write() - CORE/Cake/Cache/Cache.php, line 321
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 219
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Transcript::findByid() - APP/Controller/TranscriptController.php, line 319
TranscriptController::show() - APP/Controller/TranscriptController.php, line 319
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

Warning (512): _cake_model_ cache was unable to write 'default_citloci_list' to File cache [CORE/Cake/Cache/Cache.php, line 323]
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                ),
                E_USER_WARNING
            );
$key = 'default_citloci_list'
$value = null
$config = '_cake_model_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 219
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Transcript::findByid() - APP/Controller/TranscriptController.php, line 319
TranscriptController::show() - APP/Controller/TranscriptController.php, line 319
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

Warning (512): _cake_model_ cache was unable to write 'default_citloci_list' to File cache [CORE/Cake/Cache/Cache.php, line 323]
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                ),
                E_USER_WARNING
            );
$key = 'default_citloci_list'
$value = array(
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	(int) 1 => 'conserved_regions',
	(int) 2 => 'diffexp',
	(int) 3 => 'experiment',
	(int) 4 => 'expressed_transcripts',
	(int) 5 => 'external_accessions',
	(int) 6 => 'genes',
	(int) 7 => 'go_annotations',
	(int) 8 => 'homologues',
	(int) 9 => 'maptranscripttoregion',
	(int) 10 => 'organism',
	(int) 11 => 'sample',
	(int) 12 => 'study',
	(int) 13 => 'synonyms',
	(int) 14 => 'transcripts'
)
$config = '_cake_model_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 236
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Transcript::findByid() - APP/Controller/TranscriptController.php, line 319
TranscriptController::show() - APP/Controller/TranscriptController.php, line 319
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

Warning (512): _cake_model_ cache was unable to write 'default_citloci_transcripts' to File cache [CORE/Cake/Cache/Cache.php, line 323]
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                ),
                E_USER_WARNING
            );
$key = 'default_citloci_transcripts'
$value = null
$config = '_cake_model_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::_cacheDescription() - CORE/Cake/Model/Datasource/DataSource.php, line 310
DataSource::describe() - CORE/Cake/Model/Datasource/DataSource.php, line 135
Mysql::describe() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 332
Model::schema() - CORE/Cake/Model/Model.php, line 1372
DboSource::fields() - CORE/Cake/Model/Datasource/DboSource.php, line 2491
DboSource::read() - CORE/Cake/Model/Datasource/DboSource.php, line 1054
Model::_readDataSource() - CORE/Cake/Model/Model.php, line 2947
Model::find() - CORE/Cake/Model/Model.php, line 2919
DboSource::query() - CORE/Cake/Model/Datasource/DboSource.php, line 597
Model::__call() - CORE/Cake/Model/Model.php, line 808
Transcript::findByid() - APP/Controller/TranscriptController.php, line 319
TranscriptController::show() - APP/Controller/TranscriptController.php, line 319
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165

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                ),
                E_USER_WARNING
            );
$key = 'default_citloci_transcripts'
$value = array(
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		'collate' => 'latin1_swedish_ci',
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		'key' => 'index',
		'collate' => 'latin1_swedish_ci',
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		'collate' => 'latin1_swedish_ci',
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		'default' => null,
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		'collate' => 'latin1_swedish_ci',
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		'default' => null,
		'length' => (int) 64,
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	),
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		'charset' => 'latin1'
	),
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		'length' => (int) 8,
		'collate' => 'latin1_swedish_ci',
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$config = '_cake_model_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::_cacheDescription() - CORE/Cake/Model/Datasource/DataSource.php, line 310
Mysql::describe() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 372
Model::schema() - CORE/Cake/Model/Model.php, line 1372
DboSource::fields() - CORE/Cake/Model/Datasource/DboSource.php, line 2491
DboSource::read() - CORE/Cake/Model/Datasource/DboSource.php, line 1054
Model::_readDataSource() - CORE/Cake/Model/Model.php, line 2947
Model::find() - CORE/Cake/Model/Model.php, line 2919
DboSource::query() - CORE/Cake/Model/Datasource/DboSource.php, line 597
Model::__call() - CORE/Cake/Model/Model.php, line 808
Transcript::findByid() - APP/Controller/TranscriptController.php, line 319
TranscriptController::show() - APP/Controller/TranscriptController.php, line 319
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

• HOME
• REGIONS
• GENES
• TRANSCRIPTS
• HELP
• CONTACT

Transcript Info
Description:	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Transcript Accession	Transcript Name	Contained in Gene	Tax ID	Strand	Position	Biotype
ENST00000398960	DYRK1A-006	ENSG00000157540	9606	+	21:37420300-37512586	protein_coding

Expression Patterns Heat Map Numeric Values Transcript ID Bladder Brain Colon Heart Kidney Muscle Testis ENST00000398960 2.413±0.00 6.138±0.00 2.127±0.00 1.843±0.00 1.900±0.00 4.147±0.00 5.972±0.00

Conserved Regions
Region ID	Sub-Region	Region Type	Position
CIL_0001CZ	CIL_0001CZ_0002	CGP	21:37223420-37517450
CIL_0006ZG	CIL_0006ZG_0001	CGP	21:37365790-37916446

Gene Ontology
GO ID	Evidence Type	GO Description
GO:0000278	TAS	mitotic cell cycle
GO:0000381	IEA	regulation of alternative mRNA splicing, via spliceosome
GO:0004672	TAS:IEA	protein kinase activity
GO:0004674	ISS	protein serine/threonine kinase activity
GO:0004712	IEA	protein serine/threonine/tyrosine kinase activity
GO:0004713	ISS:IEA	protein tyrosine kinase activity
GO:0004715	IDA	non-membrane spanning protein tyrosine kinase activity
GO:0005515	IPI	protein binding
GO:0005524	IEA	ATP binding
GO:0005634	ISS	nucleus
GO:0005654	TAS	nucleoplasm
GO:0006468	ISS:IEA	protein phosphorylation
GO:0007399	TAS	nervous system development
GO:0007623	ISS	circadian rhythm
GO:0016607	ISS	nuclear speck
GO:0016772	IEA	transferase activity, transferring phosphorus-containing groups
GO:0018105	IEA	peptidyl-serine phosphorylation
GO:0018107	ISS	peptidyl-threonine phosphorylation
GO:0018108	ISS	peptidyl-tyrosine phosphorylation
GO:0030529	IEA	ribonucleoprotein complex
GO:0042802	IEA	identical protein binding
GO:0043518	ISS	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043621	ISS	protein self-association
GO:0046777	ISS	protein autophosphorylation
GO:0048156	ISS	tau protein binding
GO:0090312	ISS	positive regulation of protein deacetylation

Homologs
ENSEMBL Accession	Gene Name	Biotype	Species	E-Value	Bit Score
ENSMUST00000023614	Dyrk1a-201	protein_coding	Mus_musculus	0	3703
ENSMUST00000119878	Dyrk1a-001	protein_coding	Mus_musculus	0	3703
ENSMUST00000122284	Dyrk1a-002	protein_coding	Mus_musculus	0	3103
ENSMUST00000155791	Dyrk1a-004	protein_coding	Mus_musculus	0	965
ENSMUST00000134383	Dyrk1a-005	retained_intron	Mus_musculus	0	959
ENSDART00000100073	dyrk1aa-201	protein_coding	Danio_rerio	0	780
ENSDART00000038748	dyrk1b-001	protein_coding	Danio_rerio	0	525
ENSMUST00000139250	Dyrk1a-003	protein_coding	Mus_musculus	0	460
ENSDART00000144722	dyrk1aa-002	protein_coding	Danio_rerio	0	340
ENSDART00000141723	dyrk1aa-001	protein_coding	Danio_rerio	0	322
ENSDART00000147674	dyrk1aa-004	processed_transcript	Danio_rerio	3e-27	128

Loading

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                ),
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	'Cache' => '/var/www/c-it-loci/lib/Cake/Cache/Cache.php',
	'FileEngine' => '/var/www/c-it-loci/lib/Cake/Cache/Engine/FileEngine.php',
	'CacheEngine' => '/var/www/c-it-loci/lib/Cake/Cache/CacheEngine.php',
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	'ErrorHandler' => '/var/www/c-it-loci/lib/Cake/Error/ErrorHandler.php',
	'CakePlugin' => '/var/www/c-it-loci/lib/Cake/Core/CakePlugin.php',
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	'LogEngineCollection' => '/var/www/c-it-loci/lib/Cake/Log/LogEngineCollection.php',
	'ObjectCollection' => '/var/www/c-it-loci/lib/Cake/Utility/ObjectCollection.php',
	'FileLog' => '/var/www/c-it-loci/lib/Cake/Log/Engine/FileLog.php',
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	'CakeLogInterface' => '/var/www/c-it-loci/lib/Cake/Log/CakeLogInterface.php',
	'Debugger' => '/var/www/c-it-loci/lib/Cake/Utility/Debugger.php',
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	'CakeRequest' => '/var/www/c-it-loci/lib/Cake/Network/CakeRequest.php',
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	'CakeEventManager' => '/var/www/c-it-loci/lib/Cake/Event/CakeEventManager.php',
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)
$config = '_cake_core_'
$settings = array(
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	'serialize' => true,
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	'lock' => true,
	'isWindows' => false,
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	'probability' => (int) 100,
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)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
App::shutdown() - CORE/Cake/Core/App.php, line 899
[main] - [internal], line ??

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                ),
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$key = 'method_cache'
$value = array(
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		'f1cac05c79ebe8dd755656a25ec597a7' => '`Transcript`.`end`',
		'cb77e27a33acde1f1d541f16aa9c2a8e' => '`Transcript`.`transcript_name`',
		'4c7958e621b5890aa3788835d12d3c8c' => '`Transcript`.`transcript_source`',
		'a99f810917ca747fa263ac35165d3bbd' => '`Transcript`.`transcript_biotype`',
		'85718a755d73a123c8cbafa875fd8c34' => '`Transcript`.`annotation_version`',
		'8c6497837140572ea11ac9f79b9f25eb' => '`Transcript`'
	),
	'fields' => array(
		'6eb0704ca7a9dc21eedf21112fe58d42' => array(
			(int) 0 => '`Transcript`.`id`',
			(int) 1 => '`Transcript`.`fk_gene_id`',
			(int) 2 => '`Transcript`.`transcript_version`',
			(int) 3 => '`Transcript`.`tax_id`',
			(int) 4 => '`Transcript`.`assembly`',
			(int) 5 => '`Transcript`.`chromosome`',
			(int) 6 => '`Transcript`.`strand`',
			(int) 7 => '`Transcript`.`start`',
			(int) 8 => '`Transcript`.`end`',
			(int) 9 => '`Transcript`.`transcript_name`',
			(int) 10 => '`Transcript`.`transcript_source`',
			(int) 11 => '`Transcript`.`transcript_biotype`',
			(int) 12 => '`Transcript`.`annotation_version`'
		)
	)
)
$config = '_cake_core_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/persistent/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DboSource::__destruct() - CORE/Cake/Model/Datasource/DboSource.php, line 3539
[main] - [internal], line ??