C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: checkpoint kinase 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000402731 CHEK2-022 ENSG00000183765 9606 - 22:28687897-28734721 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BreastLungOvaryTestisENST00000402731
Transcript ID Breast Lung Ovary Testis
ENST00000402731 0.945±0.00 0.560±0.00 3.711±0.00 3.619±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008NO CIL_0008NO_0001 VISTA 22:28282570-28883176
CIL_0006WX CIL_0006WX_0002 CGP 22:28687743-28757515

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000077 TAS DNA damage checkpoint
GO:0000086 IMP G2/M transition of mitotic cell cycle
GO:0000781 IDA chromosome, telomeric region
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005654 TAS nucleoplasm
GO:0006302 IMP double-strand break repair
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006468 IDA:IEA protein phosphorylation
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0006975 IMP DNA damage induced protein phosphorylation
GO:0008630 IDA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016605 IDA PML body
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019901 IPI protein kinase binding
GO:0031625 IPI ubiquitin protein ligase binding
GO:0042176 IMP regulation of protein catabolic process
GO:0042770 IDA signal transduction in response to DNA damage
GO:0042802 IPI identical protein binding
GO:0042803 IDA protein homodimerization activity
GO:0044257 IMP cellular protein catabolic process
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0046777 IDA protein autophosphorylation
GO:0046872 IEA metal ion binding
GO:0050821 IDA protein stabilization
GO:0072428 IMP signal transduction involved in intra-S DNA damage checkpoint
GO:0090307 IMP spindle assembly involved in mitosis
GO:0090399 NAS replicative senescence

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000066160 Chek2-201 protein_coding Mus_musculus 0 935

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