C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: DAB2 interacting protein
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000408936 DAB2IP-009 ENSG00000136848 9606 + 9:121651594-121785530 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000408936
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000408936 7.478±0.00 6.845±0.00 6.003±0.00 6.427±0.00 5.971±0.00 5.257±0.00 5.927±5.49 3.359±0.00 5.395±0.00 5.336±2.90 12.879±6.62 5.036±1.67 5.249±0.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006N4 CIL_0006N4_0001 CGP 9:121567057-122093606

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000185 IDA activation of MAPKKK activity
GO:0001525 IEA angiogenesis
GO:0001933 ISS negative regulation of protein phosphorylation
GO:0005099 ISS Ras GTPase activator activity
GO:0005123 IPI death receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005622 IEA intracellular
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0006927 TAS transformed cell apoptotic process
GO:0006954 IEA inflammatory response
GO:0006986 IEA response to unfolded protein
GO:0007049 IEA cell cycle
GO:0007165 IEA signal transduction
GO:0007252 ISS I-kappaB phosphorylation
GO:0007257 IDA activation of JUN kinase activity
GO:0008285 IDA negative regulation of cell proliferation
GO:0008625 IMP extrinsic apoptotic signaling pathway via death domain receptors
GO:0010596 IMP negative regulation of endothelial cell migration
GO:0010633 IMP negative regulation of epithelial cell migration
GO:0010719 IMP negative regulation of epithelial to mesenchymal transition
GO:0010976 ISS positive regulation of neuron projection development
GO:0014067 IDA negative regulation of phosphatidylinositol 3-kinase signaling
GO:0016525 IDA negative regulation of angiogenesis
GO:0017124 IDA SH3 domain binding
GO:0019900 IPI kinase binding
GO:0019901 IPI protein kinase binding
GO:0021814 ISS cell motility involved in cerebral cortex radial glia guided migration
GO:0021819 ISS layer formation in cerebral cortex
GO:0030139 IDA endocytic vesicle
GO:0030424 ISS axon
GO:0030948 IMP negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031235 IBA intrinsic component of the cytoplasmic side of the plasma membrane
GO:0031434 IPI mitogen-activated protein kinase kinase binding
GO:0031435 IPI mitogen-activated protein kinase kinase kinase binding
GO:0032088 IMP negative regulation of NF-kappaB transcription factor activity
GO:0032266 IDA phosphatidylinositol-3-phosphate binding
GO:0032312 ISS regulation of ARF GTPase activity
GO:0032318 IEA regulation of Ras GTPase activity
GO:0032320 IBA positive regulation of Ras GTPase activity
GO:0032403 IDA protein complex binding
GO:0032809 ISS neuronal cell body membrane
GO:0034144 IDA negative regulation of toll-like receptor 4 signaling pathway
GO:0034260 ISS negative regulation of GTPase activity
GO:0034261 IMP negative regulation of Ras GTPase activity
GO:0035148 IMP tube formation
GO:0035414 ISS negative regulation of catenin import into nucleus
GO:0035591 IDA signaling adaptor activity
GO:0035924 ISS cellular response to vascular endothelial growth factor stimulus
GO:0036312 IDA phosphatidylinositol 3-kinase regulatory subunit binding
GO:0036324 ISS vascular endothelial growth factor receptor-2 signaling pathway
GO:0042059 ISS negative regulation of epidermal growth factor receptor signaling pathway
GO:0042802 IPI identical protein binding
GO:0042803 IPI protein homodimerization activity
GO:0043025 ISS neuronal cell body
GO:0043065 IDA positive regulation of apoptotic process
GO:0043122 ISS regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 IDA negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043184 IPI vascular endothelial growth factor receptor 2 binding
GO:0043254 IDA regulation of protein complex assembly
GO:0043407 IDA negative regulation of MAP kinase activity
GO:0043410 IDA positive regulation of MAPK cascade
GO:0043507 IDA positive regulation of JUN kinase activity
GO:0043548 IDA phosphatidylinositol 3-kinase binding
GO:0043553 IDA negative regulation of phosphatidylinositol 3-kinase activity
GO:0044257 IDA cellular protein catabolic process
GO:0044300 ISS cerebellar mossy fiber
GO:0044301 ISS climbing fiber
GO:0045087 IEA innate immune response
GO:0045732 ISS positive regulation of protein catabolic process
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046330 IDA positive regulation of JNK cascade
GO:0046580 IBA negative regulation of Ras protein signal transduction
GO:0048147 ISS negative regulation of fibroblast proliferation
GO:0048812 ISS neuron projection morphogenesis
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0051721 IDA protein phosphatase 2A binding
GO:0070059 ISS intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070062 IDA extracellular vesicular exosome
GO:0070273 IDA phosphatidylinositol-4-phosphate binding
GO:0070317 IDA negative regulation of G0 to G1 transition
GO:0070373 IDA negative regulation of ERK1 and ERK2 cascade
GO:0071158 IDA positive regulation of cell cycle arrest
GO:0071222 IDA cellular response to lipopolysaccharide
GO:0071347 IDA cellular response to interleukin-1
GO:0071356 IDA cellular response to tumor necrosis factor
GO:0071364 ISS cellular response to epidermal growth factor stimulus
GO:0071889 IDA 14-3-3 protein binding
GO:0071901 IDA negative regulation of protein serine/threonine kinase activity
GO:0071902 IDA positive regulation of protein serine/threonine kinase activity
GO:0072577 TAS endothelial cell apoptotic process
GO:0090090 IMP negative regulation of canonical Wnt signaling pathway
GO:0090129 ISS positive regulation of synapse maturation
GO:1900006 ISS positive regulation of dendrite development
GO:1900744 ISS regulation of p38MAPK cascade
GO:1900747 ISS negative regulation of vascular endothelial growth factor signaling pathway
GO:1901800 IMP positive regulation of proteasomal protein catabolic process
GO:1990032 ISS parallel fiber
GO:2000599 IDA negative regulation of cyclin catabolic process
GO:2001224 ISS positive regulation of neuron migration
GO:2001235 IDA positive regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000091010 Dab2ip-006 protein_coding Mus_musculus 0 4889
ENSMUST00000112987 Dab2ip-002 protein_coding Mus_musculus 0 4551
ENSMUST00000145698 Dab2ip-008 nonsense_mediated_decay Mus_musculus 0 4436
ENSMUST00000135741 Dab2ip-009 protein_coding Mus_musculus 0 4353
ENSMUST00000112986 Dab2ip-003 protein_coding Mus_musculus 0 4353
ENSMUST00000124098 Dab2ip-010 protein_coding Mus_musculus 0 4202
ENSMUST00000065001 Dab2ip-004 protein_coding Mus_musculus 0 4202
ENSMUST00000112983 Dab2ip-001 protein_coding Mus_musculus 0 4200
ENSMUST00000112981 Dab2ip-005 nonsense_mediated_decay Mus_musculus 0 3984
ENSMUST00000112992 Dab2ip-011 protein_coding Mus_musculus 0 3814
ENSMUST00000156669 Dab2ip-012 protein_coding Mus_musculus 0 1264
ENSDART00000091612 dab2ipa-201 protein_coding Danio_rerio 0 1214
ENSDART00000135812 dab2ipa-001 protein_coding Danio_rerio 0 1214
ENSDART00000093368 SYNGAP1 (1 of 2)-201 protein_coding Danio_rerio 0 612
ENSDART00000137880 SYNGAP1 (1 of 2)-001 protein_coding Danio_rerio 0 531
ENSMUST00000138957 Dab2ip-007 processed_transcript Mus_musculus 0 518
ENSMUST00000156465 Dab2ip-013 retained_intron Mus_musculus 0 503

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