C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: inositol polyphosphate-5-phosphatase K
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000421807 INPP5K-001 ENSG00000132376 9606 - 17:1494571-1516888 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000421807
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000421807 18.333±0.00 15.581±0.00 0.414±0.00 5.541±0.00 30.006±0.00 9.439±0.00 4.361±4.24 9.034±0.00 4.193±0.00 8.174±0.00 9.319±0.00 7.185±1.69 16.441±0.73 13.979±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006AE CIL_0006AE_0002 CGP 17:1494571-1562816

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001701 IEA in utero embryonic development
GO:0001726 IDA ruffle
GO:0001933 ISS negative regulation of protein phosphorylation
GO:0004445 IEA inositol-polyphosphate 5-phosphatase activity
GO:0005000 ISS vasopressin receptor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 ISS cytoplasm
GO:0005783 IDA endoplasmic reticulum
GO:0005802 IDA trans-Golgi network
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0005979 ISS regulation of glycogen biosynthetic process
GO:0006469 IDA negative regulation of protein kinase activity
GO:0006644 TAS phospholipid metabolic process
GO:0006661 TAS phosphatidylinositol biosynthetic process
GO:0007186 ISS G-protein coupled receptor signaling pathway
GO:0010801 IDA negative regulation of peptidyl-threonine phosphorylation
GO:0010829 IDA negative regulation of glucose transport
GO:0016020 IDA membrane
GO:0016311 IDA dephosphorylation
GO:0016312 IDA inositol bisphosphate phosphatase activity
GO:0030036 NAS actin cytoskeleton organization
GO:0032587 IDA ruffle membrane
GO:0032868 IEA response to insulin
GO:0032869 IDA cellular response to insulin stimulus
GO:0032870 ISS cellular response to hormone stimulus
GO:0033137 IDA negative regulation of peptidyl-serine phosphorylation
GO:0034485 IDA phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0034594 IDA phosphatidylinositol trisphosphate phosphatase activity
GO:0034595 IMP phosphatidylinositol phosphate 5-phosphatase activity
GO:0035305 ISS negative regulation of dephosphorylation
GO:0035810 ISS positive regulation of urine volume
GO:0042577 NAS lipid phosphatase activity
GO:0042593 ISS glucose homeostasis
GO:0043005 IDA neuron projection
GO:0043407 IDA negative regulation of MAP kinase activity
GO:0043922 IDA negative regulation by host of viral transcription
GO:0044281 TAS small molecule metabolic process
GO:0045719 IDA negative regulation of glycogen biosynthetic process
GO:0045869 IDA negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0046030 IDA inositol trisphosphate phosphatase activity
GO:0046627 IDA negative regulation of insulin receptor signaling pathway
GO:0046855 IDA inositol phosphate dephosphorylation
GO:0046856 IEA:IDA phosphatidylinositol dephosphorylation
GO:0048471 IDA perinuclear region of cytoplasm
GO:0051497 IDA negative regulation of stress fiber assembly
GO:0051898 IDA negative regulation of protein kinase B signaling
GO:0051926 IDA negative regulation of calcium ion transport
GO:0052658 IEA inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052659 IEA inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
GO:0071320 ISS cellular response to cAMP
GO:0071356 IDA cellular response to tumor necrosis factor
GO:0071364 IDA cellular response to epidermal growth factor stimulus
GO:0072661 ISS protein targeting to plasma membrane
GO:0090315 IDA negative regulation of protein targeting to membrane
GO:0097178 IDA ruffle assembly
GO:2000466 ISS negative regulation of glycogen (starch) synthase activity
GO:2001153 ISS positive regulation of renal water transport

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000006286 Inpp5k-001 protein_coding Mus_musculus 0 1149
ENSMUST00000150857 Inpp5k-003 nonsense_mediated_decay Mus_musculus 0 1109
ENSMUST00000136605 Inpp5k-007 retained_intron Mus_musculus 0 625
ENSMUST00000130318 Inpp5k-005 retained_intron Mus_musculus 0 357

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