Warning (512): _cake_core_ cache was unable to write 'cake_dev_eng' to File cache [CORE/Cake/Cache/Cache.php, line 323]
Code Context
                ),
                E_USER_WARNING
            );
$key = 'cake_dev_eng'
$value = array(
	'LC_MESSAGES' => array()
)
$config = '_cake_core_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/persistent/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
I18n::translate() - CORE/Cake/I18n/I18n.php, line 237
__d - CORE/Cake/basics.php, line 617
Cache::write() - CORE/Cake/Cache/Cache.php, line 321
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 219
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Transcript::findByid() - APP/Controller/TranscriptController.php, line 319
TranscriptController::show() - APP/Controller/TranscriptController.php, line 319
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

Warning (512): _cake_model_ cache was unable to write 'default_citloci_list' to File cache [CORE/Cake/Cache/Cache.php, line 323]
Code Context
                ),
                E_USER_WARNING
            );
$key = 'default_citloci_list'
$value = null
$config = '_cake_model_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 219
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Transcript::findByid() - APP/Controller/TranscriptController.php, line 319
TranscriptController::show() - APP/Controller/TranscriptController.php, line 319
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

Warning (512): _cake_model_ cache was unable to write 'default_citloci_list' to File cache [CORE/Cake/Cache/Cache.php, line 323]
Code Context
                ),
                E_USER_WARNING
            );
$key = 'default_citloci_list'
$value = array(
	(int) 0 => 'conserved_region_elements',
	(int) 1 => 'conserved_regions',
	(int) 2 => 'diffexp',
	(int) 3 => 'experiment',
	(int) 4 => 'expressed_transcripts',
	(int) 5 => 'external_accessions',
	(int) 6 => 'genes',
	(int) 7 => 'go_annotations',
	(int) 8 => 'homologues',
	(int) 9 => 'maptranscripttoregion',
	(int) 10 => 'organism',
	(int) 11 => 'sample',
	(int) 12 => 'study',
	(int) 13 => 'synonyms',
	(int) 14 => 'transcripts'
)
$config = '_cake_model_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 236
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Transcript::findByid() - APP/Controller/TranscriptController.php, line 319
TranscriptController::show() - APP/Controller/TranscriptController.php, line 319
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

Warning (512): _cake_model_ cache was unable to write 'default_citloci_transcripts' to File cache [CORE/Cake/Cache/Cache.php, line 323]
Code Context
                ),
                E_USER_WARNING
            );
$key = 'default_citloci_transcripts'
$value = null
$config = '_cake_model_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::_cacheDescription() - CORE/Cake/Model/Datasource/DataSource.php, line 310
DataSource::describe() - CORE/Cake/Model/Datasource/DataSource.php, line 135
Mysql::describe() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 332
Model::schema() - CORE/Cake/Model/Model.php, line 1372
DboSource::fields() - CORE/Cake/Model/Datasource/DboSource.php, line 2491
DboSource::read() - CORE/Cake/Model/Datasource/DboSource.php, line 1054
Model::_readDataSource() - CORE/Cake/Model/Model.php, line 2947
Model::find() - CORE/Cake/Model/Model.php, line 2919
DboSource::query() - CORE/Cake/Model/Datasource/DboSource.php, line 597
Model::__call() - CORE/Cake/Model/Model.php, line 808
Transcript::findByid() - APP/Controller/TranscriptController.php, line 319
TranscriptController::show() - APP/Controller/TranscriptController.php, line 319
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165

Warning (512): _cake_model_ cache was unable to write 'default_citloci_transcripts' to File cache [CORE/Cake/Cache/Cache.php, line 323]
Code Context
                ),
                E_USER_WARNING
            );
$key = 'default_citloci_transcripts'
$value = array(
	'id' => array(
		'type' => 'string',
		'null' => false,
		'default' => null,
		'length' => (int) 32,
		'key' => 'primary',
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'fk_gene_id' => array(
		'type' => 'string',
		'null' => false,
		'default' => null,
		'length' => (int) 32,
		'key' => 'index',
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'transcript_version' => array(
		'type' => 'string',
		'null' => true,
		'default' => null,
		'length' => (int) 8,
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'tax_id' => array(
		'type' => 'string',
		'null' => false,
		'default' => null,
		'length' => (int) 8,
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'assembly' => array(
		'type' => 'string',
		'null' => false,
		'default' => null,
		'length' => (int) 64,
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'chromosome' => array(
		'type' => 'string',
		'null' => false,
		'default' => null,
		'length' => (int) 64,
		'key' => 'index',
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'strand' => array(
		'type' => 'string',
		'null' => false,
		'default' => null,
		'length' => (int) 8,
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'start' => array(
		'type' => 'integer',
		'null' => false,
		'default' => null,
		'length' => (int) 11,
		'unsigned' => false,
		'key' => 'index'
	),
	'end' => array(
		'type' => 'integer',
		'null' => false,
		'default' => null,
		'length' => (int) 11,
		'unsigned' => false,
		'key' => 'index'
	),
	'transcript_name' => array(
		'type' => 'string',
		'null' => true,
		'default' => null,
		'length' => (int) 64,
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'transcript_source' => array(
		'type' => 'string',
		'null' => true,
		'default' => null,
		'length' => (int) 64,
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'transcript_biotype' => array(
		'type' => 'string',
		'null' => true,
		'default' => null,
		'length' => (int) 128,
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'annotation_version' => array(
		'type' => 'string',
		'null' => false,
		'default' => null,
		'length' => (int) 8,
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	)
)
$config = '_cake_model_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::_cacheDescription() - CORE/Cake/Model/Datasource/DataSource.php, line 310
Mysql::describe() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 372
Model::schema() - CORE/Cake/Model/Model.php, line 1372
DboSource::fields() - CORE/Cake/Model/Datasource/DboSource.php, line 2491
DboSource::read() - CORE/Cake/Model/Datasource/DboSource.php, line 1054
Model::_readDataSource() - CORE/Cake/Model/Model.php, line 2947
Model::find() - CORE/Cake/Model/Model.php, line 2919
DboSource::query() - CORE/Cake/Model/Datasource/DboSource.php, line 597
Model::__call() - CORE/Cake/Model/Model.php, line 808
Transcript::findByid() - APP/Controller/TranscriptController.php, line 319
TranscriptController::show() - APP/Controller/TranscriptController.php, line 319
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

• HOME
• REGIONS
• GENES
• TRANSCRIPTS
• HELP
• CONTACT

Transcript Info
Description:	glucosidase, beta, acid
Transcript Accession	Transcript Name	Contained in Gene	Tax ID	Strand	Position	Biotype
ENST00000428024	GBA-016	ENSG00000177628	9606	-	1:155234868-155244699	protein_coding

Expression Patterns Heat Map Numeric Values Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis ENST00000428024 6.758±0.00 8.833±0.00 8.118±0.00 4.406±3.54 2.650±0.00 0.915±0.86 10.482±0.00 8.852±0.00 2.807±2.17 2.329±0.00 6.063±3.78 27.753±15.22 3.095±2.58

Conserved Regions
Gene is not located within a conserved region.

Gene Ontology
GO ID	Evidence Type	GO Description
GO:0004348	IDA:IEA	glucosylceramidase activity
GO:0005102	ISS	receptor binding
GO:0005515	IPI	protein binding
GO:0005765	IDA	lysosomal membrane
GO:0005975	IEA	carbohydrate metabolic process
GO:0006665	TAS:IEA	sphingolipid metabolic process
GO:0006680	IMP	glucosylceramide catabolic process
GO:0006687	TAS	glycosphingolipid metabolic process
GO:0008219	IEA	cell death
GO:0023021	IMP	termination of signal transduction
GO:0032715	IDA	negative regulation of interleukin-6 production
GO:0035307	IMP	positive regulation of protein dephosphorylation
GO:0043202	ISS	lysosomal lumen
GO:0043407	IMP	negative regulation of MAP kinase activity
GO:0044281	TAS	small molecule metabolic process
GO:0046512	IMP	sphingosine biosynthetic process
GO:0046513	IMP	ceramide biosynthetic process
GO:0050728	IC	negative regulation of inflammatory response
GO:0070062	IDA	extracellular vesicular exosome
GO:0071356	IMP	cellular response to tumor necrosis factor

Homologs
ENSEMBL Accession	Gene Name	Biotype	Species	E-Value	Bit Score
ENSMUST00000167998	Gba-202	protein_coding	Mus_musculus	0	1526
ENSMUST00000077367	Gba-201	protein_coding	Mus_musculus	0	1526

Loading

Warning (512): _cake_core_ cache was unable to write 'file_map' to File cache [CORE/Cake/Cache/Cache.php, line 323]
Code Context
                ),
                E_USER_WARNING
            );
$key = 'file_map'
$value = array(
	'Configure' => '/var/www/c-it-loci/lib/Cake/Core/Configure.php',
	'Hash' => '/var/www/c-it-loci/lib/Cake/Utility/Hash.php',
	'Cache' => '/var/www/c-it-loci/lib/Cake/Cache/Cache.php',
	'FileEngine' => '/var/www/c-it-loci/lib/Cake/Cache/Engine/FileEngine.php',
	'CacheEngine' => '/var/www/c-it-loci/lib/Cake/Cache/CacheEngine.php',
	'Inflector' => '/var/www/c-it-loci/lib/Cake/Utility/Inflector.php',
	'ErrorHandler' => '/var/www/c-it-loci/lib/Cake/Error/ErrorHandler.php',
	'CakePlugin' => '/var/www/c-it-loci/lib/Cake/Core/CakePlugin.php',
	'CakeLog' => '/var/www/c-it-loci/lib/Cake/Log/CakeLog.php',
	'LogEngineCollection' => '/var/www/c-it-loci/lib/Cake/Log/LogEngineCollection.php',
	'ObjectCollection' => '/var/www/c-it-loci/lib/Cake/Utility/ObjectCollection.php',
	'FileLog' => '/var/www/c-it-loci/lib/Cake/Log/Engine/FileLog.php',
	'BaseLog' => '/var/www/c-it-loci/lib/Cake/Log/Engine/BaseLog.php',
	'CakeLogInterface' => '/var/www/c-it-loci/lib/Cake/Log/CakeLogInterface.php',
	'Debugger' => '/var/www/c-it-loci/lib/Cake/Utility/Debugger.php',
	'String' => '/var/www/c-it-loci/lib/Cake/Utility/String.php',
	'Dispatcher' => '/var/www/c-it-loci/lib/Cake/Routing/Dispatcher.php',
	'CakeEventListener' => '/var/www/c-it-loci/lib/Cake/Event/CakeEventListener.php',
	'CakeRequest' => '/var/www/c-it-loci/lib/Cake/Network/CakeRequest.php',
	'CakeResponse' => '/var/www/c-it-loci/lib/Cake/Network/CakeResponse.php',
	'CakeEvent' => '/var/www/c-it-loci/lib/Cake/Event/CakeEvent.php',
	'CakeEventManager' => '/var/www/c-it-loci/lib/Cake/Event/CakeEventManager.php',
	'AssetDispatcher' => '/var/www/c-it-loci/lib/Cake/Routing/Filter/AssetDispatcher.php',
	'DispatcherFilter' => '/var/www/c-it-loci/lib/Cake/Routing/DispatcherFilter.php',
	'CacheDispatcher' => '/var/www/c-it-loci/lib/Cake/Routing/Filter/CacheDispatcher.php',
	'Router' => '/var/www/c-it-loci/lib/Cake/Routing/Router.php',
	'CakeRoute' => '/var/www/c-it-loci/lib/Cake/Routing/Route/CakeRoute.php',
	'PluginShortRoute' => '/var/www/c-it-loci/lib/Cake/Routing/Route/PluginShortRoute.php',
	'TranscriptController' => '/var/www/c-it-loci/app/Controller/TranscriptController.php',
	'AppController' => '/var/www/c-it-loci/app/Controller/AppController.php',
	'Controller' => '/var/www/c-it-loci/lib/Cake/Controller/Controller.php',
	'Object' => '/var/www/c-it-loci/lib/Cake/Core/Object.php',
	'ComponentCollection' => '/var/www/c-it-loci/lib/Cake/Controller/ComponentCollection.php',
	'SessionComponent' => '/var/www/c-it-loci/lib/Cake/Controller/Component/SessionComponent.php',
	'Component' => '/var/www/c-it-loci/lib/Cake/Controller/Component.php',
	'RequestHandlerComponent' => '/var/www/c-it-loci/lib/Cake/Controller/Component/RequestHandlerComponent.php',
	'ClassRegistry' => '/var/www/c-it-loci/lib/Cake/Utility/ClassRegistry.php',
	'Transcript' => '/var/www/c-it-loci/app/Model/Transcript.php',
	'AppModel' => '/var/www/c-it-loci/app/Model/AppModel.php',
	'Model' => '/var/www/c-it-loci/lib/Cake/Model/Model.php',
	'BehaviorCollection' => '/var/www/c-it-loci/lib/Cake/Model/BehaviorCollection.php',
	'ConnectionManager' => '/var/www/c-it-loci/lib/Cake/Model/ConnectionManager.php',
	'Mysql' => '/var/www/c-it-loci/lib/Cake/Model/Datasource/Database/Mysql.php',
	'DboSource' => '/var/www/c-it-loci/lib/Cake/Model/Datasource/DboSource.php',
	'DataSource' => '/var/www/c-it-loci/lib/Cake/Model/Datasource/DataSource.php',
	'I18n' => '/var/www/c-it-loci/lib/Cake/I18n/I18n.php',
	'L10n' => '/var/www/c-it-loci/lib/Cake/I18n/L10n.php',
	'CakeSession' => '/var/www/c-it-loci/lib/Cake/Model/Datasource/CakeSession.php',
	'View' => '/var/www/c-it-loci/lib/Cake/View/View.php',
	'HelperCollection' => '/var/www/c-it-loci/lib/Cake/View/HelperCollection.php',
	'ViewBlock' => '/var/www/c-it-loci/lib/Cake/View/ViewBlock.php',
	'HtmlHelper' => '/var/www/c-it-loci/lib/Cake/View/Helper/HtmlHelper.php',
	'AppHelper' => '/var/www/c-it-loci/app/View/Helper/AppHelper.php',
	'Helper' => '/var/www/c-it-loci/lib/Cake/View/Helper.php',
	'FormHelper' => '/var/www/c-it-loci/lib/Cake/View/Helper/FormHelper.php',
	'SessionHelper' => '/var/www/c-it-loci/lib/Cake/View/Helper/SessionHelper.php'
)
$config = '_cake_core_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/persistent/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
App::shutdown() - CORE/Cake/Core/App.php, line 899
[main] - [internal], line ??

Warning (512): _cake_core_ cache was unable to write 'method_cache' to File cache [CORE/Cake/Cache/Cache.php, line 323]
Code Context
                ),
                E_USER_WARNING
            );
$key = 'method_cache'
$value = array(
	(int) 0 => false,
	'name' => array(
		'45b989c52610ac6d773f6b83d6108190' => '`citloci`',
		'f2816a5be27cbf774db1203e73495133' => '`transcripts`',
		'8165bd022016cf07bb0216f629424d65' => '`Transcript`.`id`',
		'e10a6371e6735b1981cc85600524b7ca' => '`Transcript`.`fk_gene_id`',
		'b3b5e1885e4cd068e6b338099d5729b9' => '`Transcript`.`transcript_version`',
		'7ffab25e377d3a7b93369d36dd072d54' => '`Transcript`.`tax_id`',
		'f5e763ac38b6f19fb2aec706ca43efcd' => '`Transcript`.`assembly`',
		'9b1c568cf65fba8e7e2de6dc1b67b3f9' => '`Transcript`.`chromosome`',
		'6e01bbef387a58c2ce7c4c3844dc88c0' => '`Transcript`.`strand`',
		'60b04f112f50bbdce828cbef65efa0b9' => '`Transcript`.`start`',
		'f1cac05c79ebe8dd755656a25ec597a7' => '`Transcript`.`end`',
		'cb77e27a33acde1f1d541f16aa9c2a8e' => '`Transcript`.`transcript_name`',
		'4c7958e621b5890aa3788835d12d3c8c' => '`Transcript`.`transcript_source`',
		'a99f810917ca747fa263ac35165d3bbd' => '`Transcript`.`transcript_biotype`',
		'85718a755d73a123c8cbafa875fd8c34' => '`Transcript`.`annotation_version`',
		'8c6497837140572ea11ac9f79b9f25eb' => '`Transcript`'
	),
	'fields' => array(
		'6eb0704ca7a9dc21eedf21112fe58d42' => array(
			(int) 0 => '`Transcript`.`id`',
			(int) 1 => '`Transcript`.`fk_gene_id`',
			(int) 2 => '`Transcript`.`transcript_version`',
			(int) 3 => '`Transcript`.`tax_id`',
			(int) 4 => '`Transcript`.`assembly`',
			(int) 5 => '`Transcript`.`chromosome`',
			(int) 6 => '`Transcript`.`strand`',
			(int) 7 => '`Transcript`.`start`',
			(int) 8 => '`Transcript`.`end`',
			(int) 9 => '`Transcript`.`transcript_name`',
			(int) 10 => '`Transcript`.`transcript_source`',
			(int) 11 => '`Transcript`.`transcript_biotype`',
			(int) 12 => '`Transcript`.`annotation_version`'
		)
	)
)
$config = '_cake_core_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/persistent/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DboSource::__destruct() - CORE/Cake/Model/Datasource/DboSource.php, line 3539
[main] - [internal], line ??