C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: vascular endothelial growth factor A
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000457104 VEGFA-022 ENSG00000112715 9606 + 6:43771247-43784562 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; KidneyLungENST00000457104
Transcript ID Kidney Lung
ENST00000457104 24.090±0.00 53.618±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008YI CIL_0008YI_0001 VISTA 6:43493027-44094540

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001525 IDA angiogenesis
GO:0001541 ISS ovarian follicle development
GO:0001569 ISS patterning of blood vessels
GO:0001570 TAS vasculogenesis
GO:0001666 IDA response to hypoxia
GO:0001701 ISS in utero embryonic development
GO:0001822 ISS kidney development
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0001938 ISS positive regulation of endothelial cell proliferation
GO:0001968 IDA fibronectin binding
GO:0002042 IDA cell migration involved in sprouting angiogenesis
GO:0002052 ISS positive regulation of neuroblast proliferation
GO:0002053 ISS positive regulation of mesenchymal cell proliferation
GO:0002092 IDA positive regulation of receptor internalization
GO:0002575 IDA basophil chemotaxis
GO:0002576 TAS platelet degranulation
GO:0002687 TAS positive regulation of leukocyte migration
GO:0003007 ISS heart morphogenesis
GO:0003151 ISS outflow tract morphogenesis
GO:0003169 ISS coronary vein morphogenesis
GO:0005125 ISS cytokine activity
GO:0005161 IPI platelet-derived growth factor receptor binding
GO:0005172 IPI vascular endothelial growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005578 NAS proteinaceous extracellular matrix
GO:0005615 ISS extracellular space
GO:0005737 IDA cytoplasm
GO:0006357 IMP regulation of transcription from RNA polymerase II promoter
GO:0007399 TAS nervous system development
GO:0007498 ISS mesoderm development
GO:0007595 ISS lactation
GO:0007596 TAS blood coagulation
GO:0008083 ISS:IEA growth factor activity
GO:0008201 IMP heparin binding
GO:0008284 IDA positive regulation of cell proliferation
GO:0008360 IDA regulation of cell shape
GO:0009986 IDA cell surface
GO:0010595 IDA positive regulation of endothelial cell migration
GO:0010628 IDA positive regulation of gene expression
GO:0016020 IEA membrane
GO:0030141 IDA secretory granule
GO:0030168 TAS platelet activation
GO:0030224 IDA monocyte differentiation
GO:0030225 IDA macrophage differentiation
GO:0030324 ISS lung development
GO:0030335 IDA positive regulation of cell migration
GO:0030855 ISS epithelial cell differentiation
GO:0030949 IDA positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031077 ISS post-embryonic camera-type eye development
GO:0031093 TAS platelet alpha granule lumen
GO:0031334 IDA positive regulation of protein complex assembly
GO:0031954 IDA positive regulation of protein autophosphorylation
GO:0032147 IDA activation of protein kinase activity
GO:0032793 IDA positive regulation of CREB transcription factor activity
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0035148 IDA tube formation
GO:0035767 IDA endothelial cell chemotaxis
GO:0035924 IDA cellular response to vascular endothelial growth factor stimulus
GO:0036303 ISS lymph vessel morphogenesis
GO:0038033 IDA positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0038084 IDA vascular endothelial growth factor signaling pathway
GO:0038091 IDA positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0038190 ISS VEGF-activated neuropilin signaling pathway
GO:0038191 IPI neuropilin binding
GO:0040007 ISS growth
GO:0042056 IDA chemoattractant activity
GO:0042462 ISS eye photoreceptor cell development
GO:0042802 IPI identical protein binding
GO:0042803 ISS protein homodimerization activity
GO:0043066 IMP negative regulation of apoptotic process
GO:0043117 IDA positive regulation of vascular permeability
GO:0043129 ISS surfactant homeostasis
GO:0043154 IDA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043183 IPI vascular endothelial growth factor receptor 1 binding
GO:0043184 IPI vascular endothelial growth factor receptor 2 binding
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0043536 IDA positive regulation of blood vessel endothelial cell migration
GO:0045766 IMP positive regulation of angiogenesis
GO:0045785 IDA positive regulation of cell adhesion
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IDA protein heterodimerization activity
GO:0048010 IDA vascular endothelial growth factor receptor signaling pathway
GO:0048018 IPI receptor agonist activity
GO:0048469 ISS cell maturation
GO:0048593 ISS camera-type eye morphogenesis
GO:0048739 ISS cardiac muscle fiber development
GO:0048754 ISS branching morphogenesis of an epithelial tube
GO:0048842 ISS positive regulation of axon extension involved in axon guidance
GO:0048844 ISS artery morphogenesis
GO:0050679 ISS positive regulation of epithelial cell proliferation
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050840 IC extracellular matrix binding
GO:0050918 IDA positive chemotaxis
GO:0050927 IDA positive regulation of positive chemotaxis
GO:0050930 NAS induction of positive chemotaxis
GO:0051272 IDA positive regulation of cellular component movement
GO:0051781 IEA positive regulation of cell division
GO:0051894 IDA positive regulation of focal adhesion assembly
GO:0060319 ISS primitive erythrocyte differentiation
GO:0060749 ISS mammary gland alveolus development
GO:0060754 IDA positive regulation of mast cell chemotaxis
GO:0060948 ISS cardiac vascular smooth muscle cell development
GO:0060982 ISS coronary artery morphogenesis
GO:0061418 TAS regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061419 IMP positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0071456 IDA cellular response to hypoxia
GO:0071542 ISS dopaminergic neuron differentiation
GO:0071679 ISS commissural neuron axon guidance
GO:0090037 IDA positive regulation of protein kinase C signaling
GO:0090050 IDA positive regulation of cell migration involved in sprouting angiogenesis
GO:0090190 ISS positive regulation of branching involved in ureteric bud morphogenesis
GO:0090259 ISS regulation of retinal ganglion cell axon guidance
GO:1900086 IDA positive regulation of peptidyl-tyrosine autophosphorylation
GO:1900745 IDA positive regulation of p38MAPK cascade
GO:1901727 IDA positive regulation of histone deacetylase activity
GO:1902336 ISS positive regulation of retinal ganglion cell axon guidance
GO:1902533 IDA positive regulation of intracellular signal transduction
GO:1902966 IDA positive regulation of protein localization to early endosome

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000167860 Vegfa-201 protein_coding Mus_musculus 0 462
ENSMUST00000113519 Vegfa-009 protein_coding Mus_musculus 0 462
ENSMUST00000113520 Vegfa-010 protein_coding Mus_musculus 0 462
ENSMUST00000142351 Vegfa-003 protein_coding Mus_musculus 0 462
ENSMUST00000071648 Vegfa-001 protein_coding Mus_musculus 0 462
ENSMUST00000024747 Vegfa-008 protein_coding Mus_musculus 0 462
ENSMUST00000146149 Vegfa-002 retained_intron Mus_musculus 0 340
ENSMUST00000142321 Vegfa-005 retained_intron Mus_musculus 4e-28 128
ENSMUST00000133605 Vegfa-004 retained_intron Mus_musculus 4e-28 128
ENSMUST00000150327 Vegfa-007 retained_intron Mus_musculus 4e-28 128

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