C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: lymphoid enhancer-binding factor 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000510624 LEF1-018 ENSG00000138795 9606 - 4:108048639-108166721 protein_coding

Expression Patterns

No expression data.

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00097H CIL_00097H_0001 VISTA 4:107841068-108442627
CIL_0008T5 CIL_0008T5_0001 VISTA 4:108033184-108635877

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000977 IDA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228 IMP RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001569 IBA patterning of blood vessels
GO:0001649 IEP osteoblast differentiation
GO:0001755 IBA neural crest cell migration
GO:0001756 IBA somitogenesis
GO:0001837 ISS epithelial to mesenchymal transition
GO:0002040 IBA sprouting angiogenesis
GO:0003677 ISS DNA binding
GO:0003682 IBA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IBA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IDA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0008013 IEA:IPI beta-catenin binding
GO:0008284 IDA positive regulation of cell proliferation
GO:0008301 ISS DNA binding, bending
GO:0010628 IDA positive regulation of gene expression
GO:0010718 IMP positive regulation of epithelial to mesenchymal transition
GO:0016055 IEA:IDA Wnt signaling pathway
GO:0016202 IBA regulation of striated muscle tissue development
GO:0021542 IBA dentate gyrus development
GO:0021854 IBA hypothalamus development
GO:0021861 IBA forebrain radial glial cell differentiation
GO:0021873 IBA forebrain neuroblast division
GO:0021879 IBA forebrain neuron differentiation
GO:0021943 IBA formation of radial glial scaffolds
GO:0022408 IDA negative regulation of cell-cell adhesion
GO:0022409 IDA positive regulation of cell-cell adhesion
GO:0030223 IMP neutrophil differentiation
GO:0030284 IDA estrogen receptor activity
GO:0030307 IMP positive regulation of cell growth
GO:0030326 IBA embryonic limb morphogenesis
GO:0030331 IDA estrogen receptor binding
GO:0030335 IDA positive regulation of cell migration
GO:0030509 IBA BMP signaling pathway
GO:0030854 IDA positive regulation of granulocyte differentiation
GO:0030879 IBA mammary gland development
GO:0032696 IDA negative regulation of interleukin-13 production
GO:0032713 IDA negative regulation of interleukin-4 production
GO:0032714 IDA negative regulation of interleukin-5 production
GO:0032993 IDA protein-DNA complex
GO:0035326 IDA enhancer binding
GO:0042100 IBA B cell proliferation
GO:0042393 IPI histone binding
GO:0043027 IMP cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 IMP negative regulation of apoptotic process
GO:0043154 IMP negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043392 IDA negative regulation of DNA binding
GO:0043401 IDA steroid hormone mediated signaling pathway
GO:0043565 IDA sequence-specific DNA binding
GO:0043923 IDA positive regulation by host of viral transcription
GO:0043966 IMP histone H3 acetylation
GO:0043967 IMP histone H4 acetylation
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045063 ISS T-helper 1 cell differentiation
GO:0045295 IPI gamma-catenin binding
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046632 IBA alpha-beta T cell differentiation
GO:0048069 IBA eye pigmentation
GO:0048341 IBA paraxial mesoderm formation
GO:0048747 IBA muscle fiber development
GO:0060021 ISS palate development
GO:0060070 IMP canonical Wnt signaling pathway
GO:0060325 IBA face morphogenesis
GO:0060326 IDA cell chemotaxis
GO:0060561 IBA apoptotic process involved in morphogenesis
GO:0060710 IBA chorio-allantoic fusion
GO:0061153 IBA trachea gland development
GO:0070016 IPI armadillo repeat domain binding
GO:0070742 IPI C2H2 zinc finger domain binding
GO:0071345 IMP cellular response to cytokine stimulus
GO:0071353 IDA cellular response to interleukin-4
GO:0071864 IMP positive regulation of cell proliferation in bone marrow
GO:0071866 IMP negative regulation of apoptotic process in bone marrow
GO:0071895 IBA odontoblast differentiation
GO:0071899 IDA negative regulation of estrogen receptor binding
GO:0090068 IDA positive regulation of cell cycle process
GO:0090090 IMP negative regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000066849 Lef1-006 protein_coding Mus_musculus 0 1399
ENSMUST00000106341 Lef1-004 protein_coding Mus_musculus 0 1177
ENSMUST00000098611 Lef1-002 protein_coding Mus_musculus 0 841
ENSMUST00000029611 Lef1-001 protein_coding Mus_musculus 0 841
ENSMUST00000132737 Lef1-005 retained_intron Mus_musculus 0 462
ENSMUST00000136147 Lef1-003 retained_intron Mus_musculus 0 287

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