C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: LYN proto-oncogene, Src family tyrosine kinase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000520220 LYN-003 ENSG00000254087 9606 + 8:55879835-56011381 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000520220
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000520220 7.578±0.00 25.214±0.00 2.896±0.00 2.114±0.00 1.433±1.04 2.904±0.00 2.768±0.00 3.108±0.00 15.504±12.45 0.987±0.00 2.772±0.75 10.711±2.57 1.376±1.04

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00009D CIL_00009D_0001 CGP 8:55773142-56011381
CIL_0001U6 CIL_0001U6_0001 CGP 8:55879813-56074581

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001782 ISS B cell homeostasis
GO:0001817 ISS regulation of cytokine production
GO:0001932 TAS regulation of protein phosphorylation
GO:0001933 ISS negative regulation of protein phosphorylation
GO:0002431 ISS Fc receptor mediated stimulatory signaling pathway
GO:0002513 ISS tolerance induction to self antigen
GO:0002576 ISS platelet degranulation
GO:0002768 ISS immune response-regulating cell surface receptor signaling pathway
GO:0002774 ISS Fc receptor mediated inhibitory signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0004715 TAS non-membrane spanning protein tyrosine kinase activity
GO:0004716 TAS receptor signaling protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005794 IDA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006468 IDA:IEA protein phosphorylation
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0007165 TAS signal transduction
GO:0007169 IMP transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007596 TAS blood coagulation
GO:0008284 ISS positive regulation of cell proliferation
GO:0008285 IMP negative regulation of cell proliferation
GO:0009725 ISS response to hormone
GO:0010976 IMP positive regulation of neuron projection development
GO:0016032 IEA viral process
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019899 IPI enzyme binding
GO:0023014 TAS signal transduction by phosphorylation
GO:0030168 TAS platelet activation
GO:0030218 ISS erythrocyte differentiation
GO:0031295 TAS T cell costimulation
GO:0031663 ISS lipopolysaccharide-mediated signaling pathway
GO:0033003 ISS regulation of mast cell activation
GO:0033628 IMP regulation of cell adhesion mediated by integrin
GO:0034136 ISS negative regulation of toll-like receptor 2 signaling pathway
GO:0034144 ISS negative regulation of toll-like receptor 4 signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042531 ISS positive regulation of tyrosine phosphorylation of STAT protein
GO:0043304 ISS regulation of mast cell degranulation
GO:0043407 ISS negative regulation of MAP kinase activity
GO:0044325 IPI ion channel binding
GO:0045087 TAS innate immune response
GO:0045121 IDA membrane raft
GO:0045646 ISS regulation of erythrocyte differentiation
GO:0046777 IDA protein autophosphorylation
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050777 TAS negative regulation of immune response
GO:0050855 ISS regulation of B cell receptor signaling pathway
GO:0050900 TAS leukocyte migration
GO:0051272 IDA positive regulation of cellular component movement
GO:0060397 TAS JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070062 IDA extracellular vesicular exosome
GO:0070304 IDA positive regulation of stress-activated protein kinase signaling cascade
GO:0070372 ISS regulation of ERK1 and ERK2 cascade
GO:0070373 ISS negative regulation of ERK1 and ERK2 cascade
GO:0070667 ISS negative regulation of mast cell proliferation
GO:0070668 IMP positive regulation of mast cell proliferation
GO:0071300 IMP cellular response to retinoic acid
GO:0090025 IMP regulation of monocyte chemotaxis
GO:0090330 ISS regulation of platelet aggregation
GO:0097028 ISS dendritic cell differentiation
GO:1902532 ISS negative regulation of intracellular signal transduction
GO:2000670 ISS positive regulation of dendritic cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000103010 Lyn-002 protein_coding Mus_musculus 0 1869
ENSMUST00000041377 Lyn-001 protein_coding Mus_musculus 0 1725
ENSMUST00000121996 Gm11787-001 unprocessed_pseudogene Mus_musculus 0 1114
ENSDART00000082356 lck-201 protein_coding Danio_rerio 0 204
ENSDART00000105478 lck-202 protein_coding Danio_rerio 0 204
ENSDART00000148860 lck-001 protein_coding Danio_rerio 0 204
ENSDART00000126663 lck-002 protein_coding Danio_rerio 0 204

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