C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: tuberous sclerosis 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000545250 TSC1-202 ENSG00000165699 9606 - 9:132891350-132928955 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBreastColonKidneyLungMuscleOvaryTestisENST00000545250
Transcript ID Adrenal Breast Colon Kidney Lung Muscle Ovary Testis
ENST00000545250 4.754±0.00 1.315±0.32 1.749±0.00 3.084±0.00 1.466±0.00 2.722±0.00 2.601±1.54 6.398±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001952 IMP regulation of cell-matrix adhesion
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0005884 IDA actin filament
GO:0005938 IDA cell cortex
GO:0006407 IMP rRNA export from nucleus
GO:0006417 IDA regulation of translation
GO:0007050 TAS cell cycle arrest
GO:0007160 IMP cell-matrix adhesion
GO:0008285 IMP negative regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0016020 IDA membrane
GO:0017148 IMP negative regulation of translation
GO:0030027 IDA lamellipodium
GO:0030695 IBA GTPase regulator activity
GO:0032007 IMP negative regulation of TOR signaling
GO:0032862 IDA activation of Rho GTPase activity
GO:0032868 IDA response to insulin
GO:0033596 IDA TSC1-TSC2 complex
GO:0043234 IDA protein complex
GO:0043666 IMP regulation of phosphoprotein phosphatase activity
GO:0046627 IBA negative regulation of insulin receptor signaling pathway
GO:0047485 IPI protein N-terminus binding
GO:0050821 IDA protein stabilization
GO:0051087 IPI chaperone binding
GO:0051492 IDA regulation of stress fiber assembly
GO:0051726 IBA regulation of cell cycle
GO:0051894 IDA positive regulation of focal adhesion assembly

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000113869 Tsc1-001 protein_coding Mus_musculus 0 3432
ENSMUST00000113870 Tsc1-201 protein_coding Mus_musculus 0 3411
ENSMUST00000028155 Tsc1-002 protein_coding Mus_musculus 0 3411
ENSMUST00000133565 Tsc1-004 nonsense_mediated_decay Mus_musculus 0 3395
ENSMUST00000113867 Tsc1-007 protein_coding Mus_musculus 0 3321
ENSMUST00000153625 Tsc1-006 retained_intron Mus_musculus 0 809
ENSMUST00000156857 Tsc1-003 nonsense_mediated_decay Mus_musculus 0 809
ENSMUST00000150274 Tsc1-009 retained_intron Mus_musculus 0 483
ENSMUST00000124507 Tsc1-008 retained_intron Mus_musculus 4e-30 139

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