C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cholinergic receptor, nicotinic, alpha polypeptide 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSDARG00000009021 chrna1 7955 - 6:10723284-10739870 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSDART00000020261 chrna1-001 10723284-10739870 protein_coding
  ENSDART00000131458 chrna1-003 10732519-10739827 protein_coding
  ENSDART00000138203 chrna1-002 10723840-10729493 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainHeartKidneyLiverMuscleENSDART00000020261ENSDART00000131458ENSDART00000138203
Transcript ID Brain Heart Kidney Liver Muscle
ENSDART00000020261 0.119±0.05 0.350±0.08 2.725±0.47 0.042±0.00 46.373±0.00
ENSDART00000131458 0.170±0.00 N/A N/A N/A N/A
ENSDART00000138203 0.424±0.23 0.950±0.09 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003428 IMP chondrocyte intercalation involved in growth plate cartilage morphogenesis
GO:0004889 IEA acetylcholine-activated cation-selective channel activity
GO:0005216 IEA ion channel activity
GO:0005230 IEA extracellular ligand-gated ion channel activity
GO:0005261 IDA cation channel activity
GO:0005886 IEA plasma membrane
GO:0005892 IMP acetylcholine-gated channel complex
GO:0006810 IEA transport
GO:0006811 IEA ion transport
GO:0006812 IDA cation transport
GO:0007271 IDA synaptic transmission, cholinergic
GO:0007274 IDA neuromuscular synaptic transmission
GO:0008045 IMP motor neuron axon guidance
GO:0015464 IDA acetylcholine receptor activity
GO:0016020 IEA membrane
GO:0016021 IEA integral to membrane
GO:0030054 IEA cell junction
GO:0030516 IMP regulation of axon extension
GO:0034220 IDA ion transmembrane transport
GO:0042166 IMP acetylcholine binding
GO:0043113 IMP receptor clustering
GO:0045202 IEA synapse
GO:0045211 IEA postsynaptic membrane
GO:0048705 IMP skeletal system morphogenesis
GO:0048741 IMP skeletal muscle fiber development
GO:0086009 IMP membrane repolarization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000138435 CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) protein_coding Homo_sapiens
ENSMUSG00000027107 Chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) protein_coding Mus_musculus

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