C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cholinergic receptor, nicotinic, alpha 1 (muscle)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000138435 CHRNA1 9606 - 2:174747592-174764472 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261007 CHRNA1-002 174747660-174764461 protein_coding
  ENST00000348749 CHRNA1-001 174747592-174764472 protein_coding
  ENST00000409219 CHRNA1-005 174747810-174764412 protein_coding
  ENST00000409323 CHRNA1-004 174752755-174764453 protein_coding
  ENST00000409542 CHRNA1-003 174747810-174764412 protein_coding
  ENST00000435083 CHRNA1-006 174747810-174764412 nonsense_mediated_decay

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartLiverLungMuscleOvaryPlacentaTestisENST00000261007ENST00000348749ENST00000409219ENST00000409323ENST00000409542ENST00000435083
Transcript ID Adipose Adrenal Brain Breast Colon Heart Liver Lung Muscle Ovary Placenta Testis
ENST00000261007 N/A N/A 0.131±0.00 N/A N/A N/A N/A N/A 4.600±3.85 N/A N/A N/A
ENST00000348749 0.209±0.00 N/A 0.485±0.00 0.542±0.18 0.253±0.00 0.220±0.00 N/A 0.501±0.00 22.302±19.83 0.168±0.03 0.221±0.05 1.659±0.00
ENST00000409219 N/A 0.001±0.00 0.123±0.06 N/A N/A 0.021±0.00 N/A N/A N/A N/A N/A N/A
ENST00000409323 N/A N/A 0.028±0.00 N/A N/A N/A N/A N/A N/A 0.034±0.00 0.035±0.00 N/A
ENST00000409542 N/A 0.010±0.00 N/A N/A N/A N/A 0.010±0.00 N/A 21.542±0.00 0.177±0.00 0.106±0.00 0.596±0.51
ENST00000435083 0.253±0.00 N/A N/A N/A N/A 0.153±0.00 N/A N/A N/A 0.047±0.00 0.086±0.02 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001H9 CIL_0001H9_0001 CGP 2:174559572-174764472
CIL_0001HC CIL_0001HC_0001 CGP 2:174747592-175005369

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003009 IMP skeletal muscle contraction
GO:0004889 IMP acetylcholine-activated cation-selective channel activity
GO:0005216 TAS ion channel activity
GO:0005230 IEA extracellular ligand-gated ion channel activity
GO:0005515 IEA protein binding
GO:0005886 ISS plasma membrane
GO:0005892 ISS acetylcholine-gated channel complex
GO:0006810 TAS:IEA transport
GO:0006811 IEA ion transport
GO:0006812 TAS cation transport
GO:0007165 TAS signal transduction
GO:0007268 TAS synaptic transmission
GO:0007274 IMP neuromuscular synaptic transmission
GO:0007528 IMP neuromuscular junction development
GO:0009986 IDA cell surface
GO:0015464 ISS acetylcholine receptor activity
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0019228 IMP neuronal action potential
GO:0030054 IEA cell junction
GO:0031594 ISS neuromuscular junction
GO:0034220 TAS ion transmembrane transport
GO:0042166 ISS acetylcholine binding
GO:0042391 IMP regulation of membrane potential
GO:0045211 NAS postsynaptic membrane
GO:0046716 IMP muscle cell cellular homeostasis
GO:0048630 IMP skeletal muscle tissue growth
GO:0050881 IMP musculoskeletal movement
GO:0050905 IMP neuromuscular process
GO:0070050 IMP neuron cellular homeostasis
GO:0098655 IEA cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009021 chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 protein_coding Danio_rerio
ENSMUSG00000027107 Chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) protein_coding Mus_musculus

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