C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: insulin-like growth factor 1 (somatomedin C)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000017427 IGF1 9606 - 12:102395867-102480645 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000307046 IGF1-002 102417491-102480563 protein_coding
  ENST00000337514 IGF1-001 102395874-102480645 protein_coding
  ENST00000392904 IGF1-005 102402328-102480638 protein_coding
  ENST00000392905 IGF1-003 102402517-102480324 protein_coding
  ENST00000424202 IGF1-004 102402459-102478651 protein_coding
  ENST00000456098 IGF1-201 102395867-102480600 protein_coding
  ENST00000481539 IGF1-006 102402247-102415746 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000307046ENST00000337514ENST00000424202ENST00000456098
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000307046 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.780±0.00 N/A N/A 2.388±0.00 N/A
ENST00000337514 3.354±0.00 0.666±0.00 0.699±0.00 1.443±0.00 5.580±1.03 2.804±0.44 1.272±0.62 14.242±0.00 4.239±1.69 1.613±0.00 0.437±0.09 2.000±1.90 4.097±3.24 4.136±2.07
ENST00000424202 N/A N/A 6.352±0.00 N/A N/A 11.855±0.00 N/A 56.750±0.00 27.366±0.00 N/A 6.587±0.00 10.748±0.00 N/A N/A
ENST00000456098 N/A 1.039±0.00 N/A N/A 1.657±0.00 N/A N/A N/A N/A N/A N/A 0.277±0.00 N/A 4.238±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008WS CIL_0008WS_0001 VISTA 12:102169845-102772373

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001501 TAS skeletal system development
GO:0001775 IDA cell activation
GO:0001932 IEA regulation of protein phosphorylation
GO:0001974 IEA blood vessel remodeling
GO:0002576 TAS platelet degranulation
GO:0005158 IPI insulin receptor binding
GO:0005159 IPI insulin-like growth factor receptor binding
GO:0005178 IDA integrin binding
GO:0005179 IDA:IEA hormone activity
GO:0005515 IPI protein binding
GO:0005576 NAS:IEA extracellular region
GO:0005615 IDA extracellular space
GO:0005886 TAS plasma membrane
GO:0006260 TAS DNA replication
GO:0006928 TAS cellular component movement
GO:0007165 TAS signal transduction
GO:0007265 TAS Ras protein signal transduction
GO:0007399 IEA nervous system development
GO:0007517 TAS muscle organ development
GO:0007596 TAS blood coagulation
GO:0008083 IEA growth factor activity
GO:0008284 IDA positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0009441 TAS glycolate metabolic process
GO:0010001 IEA glial cell differentiation
GO:0010613 IDA positive regulation of cardiac muscle hypertrophy
GO:0014068 IDA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014834 IDA skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0014896 IMP muscle hypertrophy
GO:0014904 IDA myotube cell development
GO:0014911 IDA positive regulation of smooth muscle cell migration
GO:0016942 IC insulin-like growth factor binding protein complex
GO:0021940 IEA positive regulation of cerebellar granule cell precursor proliferation
GO:0030104 IEA water homeostasis
GO:0030166 IDA proteoglycan biosynthetic process
GO:0030168 TAS platelet activation
GO:0030324 IEA lung development
GO:0030879 IEA mammary gland development
GO:0031017 IEA exocrine pancreas development
GO:0031093 TAS platelet alpha granule lumen
GO:0032878 IEA regulation of establishment or maintenance of cell polarity
GO:0033160 IDA positive regulation of protein import into nucleus, translocation
GO:0034392 IDA negative regulation of smooth muscle cell apoptotic process
GO:0035264 IEA multicellular organism growth
GO:0035630 IDA bone mineralization involved in bone maturation
GO:0040014 IEP regulation of multicellular organism growth
GO:0042104 IDA positive regulation of activated T cell proliferation
GO:0042523 IDA positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043066 IEA negative regulation of apoptotic process
GO:0043388 IDA positive regulation of DNA binding
GO:0043410 IDA positive regulation of MAPK cascade
GO:0043568 IDA positive regulation of insulin-like growth factor receptor signaling pathway
GO:0044267 TAS cellular protein metabolic process
GO:0045445 IDA myoblast differentiation
GO:0045669 IDA positive regulation of osteoblast differentiation
GO:0045725 IDA positive regulation of glycogen biosynthetic process
GO:0045740 ISS positive regulation of DNA replication
GO:0045821 IDA positive regulation of glycolytic process
GO:0045840 IDA positive regulation of mitosis
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046326 IDA positive regulation of glucose import
GO:0046579 IDA positive regulation of Ras protein signal transduction
GO:0048009 IEA insulin-like growth factor receptor signaling pathway
GO:0048015 IDA phosphatidylinositol-mediated signaling
GO:0048146 IDA positive regulation of fibroblast proliferation
GO:0048286 IEA lung alveolus development
GO:0048468 IEA cell development
GO:0048661 IDA positive regulation of smooth muscle cell proliferation
GO:0048754 IEA branching morphogenesis of an epithelial tube
GO:0048839 IEA inner ear development
GO:0050650 IEA chondroitin sulfate proteoglycan biosynthetic process
GO:0050679 IDA positive regulation of epithelial cell proliferation
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0051246 IEA regulation of protein metabolic process
GO:0051450 IDA myoblast proliferation
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0060426 IEA lung vasculature development
GO:0060463 IEA lung lobe morphogenesis
GO:0060509 IEA Type I pneumocyte differentiation
GO:0060510 IEA Type II pneumocyte differentiation
GO:0060527 IEA prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060736 IEA prostate gland growth
GO:0060740 IEA prostate gland epithelium morphogenesis
GO:0060741 IEA prostate gland stromal morphogenesis
GO:0060766 IEA negative regulation of androgen receptor signaling pathway
GO:0070373 IEA negative regulation of ERK1 and ERK2 cascade
GO:0070886 IDA positive regulation of calcineurin-NFAT signaling cascade
GO:0090201 ISS negative regulation of release of cytochrome c from mitochondria
GO:0097192 IEA extrinsic apoptotic signaling pathway in absence of ligand
GO:2000288 IEA positive regulation of myoblast proliferation
GO:2001237 IDA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000094132 igf1 insulin-like growth factor 1 protein_coding Danio_rerio
ENSMUSG00000020053 Igf1 insulin-like growth factor 1 protein_coding Mus_musculus

Loading